SE8303862D0 - NEW COMPOUND 2- (HEXAHYDROAZEPINE) -N- (2,6-DIMETHYLPHENYL) ACETAMIDE, THE CHLORETTE OF THIS SUBSTANCE, PROCEDURE FOR PREPARING THE SUBSTANCE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SUBSTANCES - Google Patents
NEW COMPOUND 2- (HEXAHYDROAZEPINE) -N- (2,6-DIMETHYLPHENYL) ACETAMIDE, THE CHLORETTE OF THIS SUBSTANCE, PROCEDURE FOR PREPARING THE SUBSTANCE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SUBSTANCESInfo
- Publication number
- SE8303862D0 SE8303862D0 SE8303862A SE8303862A SE8303862D0 SE 8303862 D0 SE8303862 D0 SE 8303862D0 SE 8303862 A SE8303862 A SE 8303862A SE 8303862 A SE8303862 A SE 8303862A SE 8303862 D0 SE8303862 D0 SE 8303862D0
- Authority
- SE
- Sweden
- Prior art keywords
- substance
- dimethylphenyl
- acetamide
- hexahydroazepine
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
New compounds, 2-(hexahydroazepino)- N-(2,6-dimethylphenyl)- acetamide, and its acid addition salts, especially the hydrochloride thereof, and pharmaceutical compositions containing them are prepared by reacting 2,6-dimethylaniline with chloracetyl chloride to give 2-chloro- N-(2,6-dimethylphenyl)-acetamide which is reacted in turn with hexahydroazepine. The new compound and the derivatives thereof have local anaesthetic activity and anti- arrhythmic activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES513980A ES8305724A1 (en) | 1982-07-14 | 1982-07-14 | Substituted acetamides, a process for their preparation and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8303862D0 true SE8303862D0 (en) | 1983-07-06 |
SE8303862L SE8303862L (en) | 1984-01-15 |
Family
ID=8484458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8303862A SE8303862L (en) | 1982-07-14 | 1983-07-06 | NEW COMPOUND 2- (HEXAHYDROAZEPINE) -N- (2,6-DIMETHYLPHENYL) ACETAMIDE, THE CHLORETTE OF THIS SUBSTANCE, PROCEDURE FOR PREPARING THE SUBSTANCE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SUBSTANCES |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS5951272A (en) |
BE (1) | BE897281A (en) |
CA (1) | CA1215048A (en) |
DE (1) | DE3325004A1 (en) |
ES (1) | ES8305724A1 (en) |
FR (1) | FR2530244B1 (en) |
GB (1) | GB2124223B (en) |
IT (1) | IT1169538B (en) |
NL (1) | NL8302507A (en) |
SE (1) | SE8303862L (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8900685D0 (en) * | 1989-02-28 | 1989-02-28 | Astra Ab | NEW COMPOUNDS |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR907128A (en) * | 1943-07-15 | 1946-03-01 | Astra Ab | Process for preparing local anesthesia products |
DE963427C (en) * | 1952-12-17 | 1957-05-09 | Cassella Farbwerke Mainkur Ag | Process for the production of new anesthetically acting aminocarboxamides |
HU183721B (en) * | 1981-11-06 | 1984-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing new cyclic imine derivatives |
-
1982
- 1982-07-14 ES ES513980A patent/ES8305724A1/en not_active Expired
-
1983
- 1983-07-06 SE SE8303862A patent/SE8303862L/en not_active Application Discontinuation
- 1983-07-11 DE DE19833325004 patent/DE3325004A1/en not_active Withdrawn
- 1983-07-11 JP JP58126819A patent/JPS5951272A/en active Pending
- 1983-07-12 CA CA000432227A patent/CA1215048A/en not_active Expired
- 1983-07-13 IT IT22053/83A patent/IT1169538B/en active
- 1983-07-13 NL NL8302507A patent/NL8302507A/en not_active Application Discontinuation
- 1983-07-13 BE BE6/47848A patent/BE897281A/en not_active IP Right Cessation
- 1983-07-13 FR FR8311715A patent/FR2530244B1/en not_active Expired
- 1983-07-14 GB GB08319108A patent/GB2124223B/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB8319108D0 (en) | 1983-08-17 |
ES513980A0 (en) | 1983-04-16 |
IT8322053A1 (en) | 1985-01-13 |
SE8303862L (en) | 1984-01-15 |
JPS5951272A (en) | 1984-03-24 |
IT8322053A0 (en) | 1983-07-13 |
ES8305724A1 (en) | 1983-04-16 |
FR2530244B1 (en) | 1986-10-31 |
BE897281A (en) | 1983-11-03 |
IT1169538B (en) | 1987-06-03 |
CA1215048A (en) | 1986-12-09 |
GB2124223A (en) | 1984-02-15 |
FR2530244A1 (en) | 1984-01-20 |
NL8302507A (en) | 1984-02-01 |
GB2124223B (en) | 1985-09-04 |
DE3325004A1 (en) | 1984-01-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
NAV | Patent application has lapsed |
Ref document number: 8303862-0 Effective date: 19881001 |