SE8301725L - SUBSTITUTED 3,4-DIAMINO-1,2,5-THIADIAZOLES WITH HISTAMINE-H? 712 RECEPTOR ANTAGONIST ACTIVITY - Google Patents

SUBSTITUTED 3,4-DIAMINO-1,2,5-THIADIAZOLES WITH HISTAMINE-H? 712 RECEPTOR ANTAGONIST ACTIVITY

Info

Publication number
SE8301725L
SE8301725L SE8301725A SE8301725A SE8301725L SE 8301725 L SE8301725 L SE 8301725L SE 8301725 A SE8301725 A SE 8301725A SE 8301725 A SE8301725 A SE 8301725A SE 8301725 L SE8301725 L SE 8301725L
Authority
SE
Sweden
Prior art keywords
histamine
substituted
thiadiazoles
diamino
receptor antagonist
Prior art date
Application number
SE8301725A
Other languages
Swedish (sv)
Other versions
SE461040B (en
SE8301725D0 (en
Inventor
R R Crenshaw
A A Algieri
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8301725D0 publication Critical patent/SE8301725D0/en
Publication of SE8301725L publication Critical patent/SE8301725L/en
Publication of SE461040B publication Critical patent/SE461040B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Histamine H2-receptor antagonists of the formula <IMAGE> wherein A, m, Z, n and R<1> are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepared by ring closure of a substituted ethanediimidamide of the formula <IMAGE>
SE8301725A 1982-03-29 1983-03-28 SUBSTITUTED 3,4-DIAMINO-1,2,5-THIADIAZOLES AND PROCEDURES FOR PREPARING THEREOF SE461040B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36320782A 1982-03-29 1982-03-29

Publications (3)

Publication Number Publication Date
SE8301725D0 SE8301725D0 (en) 1983-03-28
SE8301725L true SE8301725L (en) 1983-11-25
SE461040B SE461040B (en) 1989-12-18

Family

ID=23429274

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8301725A SE461040B (en) 1982-03-29 1983-03-28 SUBSTITUTED 3,4-DIAMINO-1,2,5-THIADIAZOLES AND PROCEDURES FOR PREPARING THEREOF
SE8704689A SE464302B (en) 1982-03-29 1987-11-25 ETHANIIMIDAMIDES AS INTERMEDIATES FOR THE PREPARATION OF HISTAMIN -H2 RECEPTOR ANTAGONISTS AND PROCEDURES FOR THE PRODUCTION OF THEREOF

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8704689A SE464302B (en) 1982-03-29 1987-11-25 ETHANIIMIDAMIDES AS INTERMEDIATES FOR THE PREPARATION OF HISTAMIN -H2 RECEPTOR ANTAGONISTS AND PROCEDURES FOR THE PRODUCTION OF THEREOF

Country Status (30)

Country Link
JP (2) JPS58180477A (en)
KR (1) KR880002209B1 (en)
AT (1) AT386599B (en)
AU (2) AU557577B2 (en)
BE (1) BE896291A (en)
CH (2) CH655111A5 (en)
CS (2) CS250240B2 (en)
DD (2) DD219768A5 (en)
DE (1) DE3311281A1 (en)
DK (2) DK166677B1 (en)
ES (3) ES8404683A1 (en)
FR (2) FR2542741B1 (en)
GB (2) GB2117769B (en)
GR (1) GR78524B (en)
HU (2) HU188742B (en)
IE (1) IE55596B1 (en)
IL (1) IL68259A0 (en)
IT (1) IT1164633B (en)
LU (1) LU84716A1 (en)
MY (1) MY8700942A (en)
NL (1) NL8301063A (en)
NO (1) NO163055C (en)
NZ (1) NZ203726A (en)
OA (1) OA07356A (en)
PT (1) PT76459B (en)
SE (2) SE461040B (en)
SU (2) SU1419518A3 (en)
YU (1) YU44849B (en)
ZA (1) ZA832154B (en)
ZW (1) ZW7683A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives
US4593039A (en) * 1984-04-02 1986-06-03 Merck & Co., Inc. 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols
US4644006A (en) * 1984-06-22 1987-02-17 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
JPH0622828B2 (en) * 1986-06-30 1994-03-30 フアナツク株式会社 Direct pressure type mold clamping mechanism
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3018289A (en) * 1960-02-10 1962-01-23 Wyandotte Chemicals Corp Process for preparing oxamidines
GB1595291A (en) * 1976-09-21 1981-08-12 Smith Kline French Lab Pyrimidone and thiopyrimidone derivatives
NL189197C (en) * 1979-09-04 1993-02-01 Bristol Myers Squibb Co 3,4-SUBSTITUTED-1,2,5-THIADIAZOLO-1-OXIDES AND 1,1-DIOXIDES, PREPARATION THEREOF, AND PHARMACEUTICAL PREPARATIONS.
EP0040696B1 (en) * 1980-04-30 1986-08-27 Merck & Co. Inc. Aminothiadiazoles as gastric secretion inhibitors
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives

Also Published As

Publication number Publication date
DK81192A (en) 1992-06-18
JPH06135925A (en) 1994-05-17
KR880002209B1 (en) 1988-10-18
GR78524B (en) 1984-09-27
JPH0568472B2 (en) 1993-09-29
SE461040B (en) 1989-12-18
GB8308518D0 (en) 1983-05-05
NO163055B (en) 1989-12-18
IT1164633B (en) 1987-04-15
DD219768A5 (en) 1985-03-13
DK141383D0 (en) 1983-03-28
CS250240B2 (en) 1987-04-16
DK81192D0 (en) 1992-06-18
DK166677B1 (en) 1993-06-28
FR2542741B1 (en) 1989-12-08
YU74483A (en) 1986-02-28
CH660880A5 (en) 1987-05-29
AU557577B2 (en) 1986-12-24
FR2597867B1 (en) 1989-12-08
NL8301063A (en) 1983-10-17
SU1355123A3 (en) 1987-11-23
AU586037B2 (en) 1989-06-29
AT386599B (en) 1988-09-12
LU84716A1 (en) 1983-12-05
ES520982A0 (en) 1984-05-16
ES8404683A1 (en) 1984-05-16
DE3311281A1 (en) 1983-11-24
ES527686A0 (en) 1985-06-16
SE464302B (en) 1991-04-08
SE8704689D0 (en) 1987-11-25
GB2117769B (en) 1985-08-29
YU44849B (en) 1991-04-30
MY8700942A (en) 1987-12-31
GB2149406B (en) 1986-01-02
DK141383A (en) 1983-09-30
GB2149406A (en) 1985-06-12
PT76459A (en) 1983-04-01
HU196386B (en) 1988-11-28
FR2597867A1 (en) 1987-10-30
NO163055C (en) 1990-03-28
ZA832154B (en) 1983-12-28
CH655111A5 (en) 1986-03-27
KR840004095A (en) 1984-10-06
OA07356A (en) 1984-08-31
NZ203726A (en) 1986-05-09
PT76459B (en) 1986-03-11
NO831100L (en) 1983-09-30
IT8348005A0 (en) 1983-03-28
ES527685A0 (en) 1985-06-16
ATA111083A (en) 1988-02-15
SU1419518A3 (en) 1988-08-23
GB2117769A (en) 1983-10-19
ZW7683A1 (en) 1984-01-04
HU188742B (en) 1986-05-28
GB8432809D0 (en) 1985-02-06
IE830686L (en) 1983-09-29
AU1290783A (en) 1983-10-06
SE8704689L (en) 1987-11-25
ES8505978A1 (en) 1985-06-16
CS250229B2 (en) 1987-04-16
IE55596B1 (en) 1990-11-21
IL68259A0 (en) 1983-06-15
BE896291A (en) 1983-09-28
FR2542741A1 (en) 1984-09-21
ES8505977A1 (en) 1985-06-16
SE8301725D0 (en) 1983-03-28
AU6327286A (en) 1987-01-08
JPS58180477A (en) 1983-10-21
DD210909A5 (en) 1984-06-27

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