SE8207306L - DIHYDRO- AND TETRAHYDROMONACOLINE L, METAL SALTS AND ALKYLESTES THEREOF SA WELL AS PROCEDURE FOR THE PRODUCTION OF THEM - Google Patents
DIHYDRO- AND TETRAHYDROMONACOLINE L, METAL SALTS AND ALKYLESTES THEREOF SA WELL AS PROCEDURE FOR THE PRODUCTION OF THEMInfo
- Publication number
- SE8207306L SE8207306L SE8207306A SE8207306A SE8207306L SE 8207306 L SE8207306 L SE 8207306L SE 8207306 A SE8207306 A SE 8207306A SE 8207306 A SE8207306 A SE 8207306A SE 8207306 L SE8207306 L SE 8207306L
- Authority
- SE
- Sweden
- Prior art keywords
- dihydro
- tetrahydromonacoline
- alkylestes
- procedure
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/11—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Abstract
Dihydro- and tetrahydromonacolin L, of the general formula (I> <IMAGE> wherein X stands for-CH=CH- or -CH2-CH2- and derivatives thereof of formula <IMAGE> where Y is a metal cation or an alkyl group have cholesterol-reducing activity, making them useful as hyperlipemia treating agents. Dihydromonacolin L can be prepared by cultivation of a microorganism of the genus Monascus. The other compounds can be prepared by synthesis from dihydromonacolin L.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56214788A JPS58109480A (en) | 1981-12-23 | 1981-12-23 | Novel physiologically active substance, dihydromonacolin l and its preparation |
JP2374582A JPS58144318A (en) | 1982-02-17 | 1982-02-17 | Tetrahydromonacolin l, its derivative and remedy for hyperlipemia comprising it as active ingredient |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8207306D0 SE8207306D0 (en) | 1982-12-21 |
SE8207306L true SE8207306L (en) | 1983-06-24 |
Family
ID=26361156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8207306A SE8207306L (en) | 1981-12-23 | 1982-12-21 | DIHYDRO- AND TETRAHYDROMONACOLINE L, METAL SALTS AND ALKYLESTES THEREOF SA WELL AS PROCEDURE FOR THE PRODUCTION OF THEM |
Country Status (9)
Country | Link |
---|---|
AU (1) | AU9133682A (en) |
BE (1) | BE895445A (en) |
DE (1) | DE3247175A1 (en) |
DK (1) | DK568882A (en) |
FR (1) | FR2518546A1 (en) |
GB (1) | GB2111989B (en) |
IT (1) | IT8249711A0 (en) |
NL (1) | NL8204904A (en) |
SE (1) | SE8207306L (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5354772A (en) * | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
US4472426A (en) * | 1982-12-22 | 1984-09-18 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
US4613610A (en) * | 1984-06-22 | 1986-09-23 | Sandoz Pharmaceuticals Corp. | Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives |
US4686237A (en) * | 1984-07-24 | 1987-08-11 | Sandoz Pharmaceuticals Corp. | Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof |
US4804679A (en) * | 1984-07-24 | 1989-02-14 | Sandoz Pharm. Corp. | Erythro-(E)-7-(3'-C1-3alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl)-3,5-dihydroxyhept-6-enoic acids and derivatives thereof |
US4647576A (en) * | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
US4668794A (en) * | 1985-05-22 | 1987-05-26 | Sandoz Pharm. Corp. | Intermediate imidazole acrolein analogs |
-
1982
- 1982-12-08 AU AU91336/82A patent/AU9133682A/en not_active Abandoned
- 1982-12-09 GB GB08235197A patent/GB2111989B/en not_active Expired
- 1982-12-20 NL NL8204904A patent/NL8204904A/en not_active Application Discontinuation
- 1982-12-21 DE DE19823247175 patent/DE3247175A1/en not_active Withdrawn
- 1982-12-21 FR FR8221416A patent/FR2518546A1/en not_active Withdrawn
- 1982-12-21 IT IT8249711A patent/IT8249711A0/en unknown
- 1982-12-21 SE SE8207306A patent/SE8207306L/en not_active Application Discontinuation
- 1982-12-22 DK DK568882A patent/DK568882A/en not_active Application Discontinuation
- 1982-12-22 BE BE0/209788A patent/BE895445A/en unknown
Also Published As
Publication number | Publication date |
---|---|
GB2111989A (en) | 1983-07-13 |
AU9133682A (en) | 1983-06-30 |
NL8204904A (en) | 1983-07-18 |
IT8249711A0 (en) | 1982-12-21 |
BE895445A (en) | 1983-04-15 |
FR2518546A1 (en) | 1983-06-24 |
GB2111989B (en) | 1985-05-09 |
SE8207306D0 (en) | 1982-12-21 |
DE3247175A1 (en) | 1983-07-07 |
DK568882A (en) | 1983-06-24 |
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Legal Events
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NAV | Patent application has lapsed |
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