SE8201557L - REVERSIBLE MICROCAPPING - Google Patents

REVERSIBLE MICROCAPPING

Info

Publication number
SE8201557L
SE8201557L SE8201557A SE8201557A SE8201557L SE 8201557 L SE8201557 L SE 8201557L SE 8201557 A SE8201557 A SE 8201557A SE 8201557 A SE8201557 A SE 8201557A SE 8201557 L SE8201557 L SE 8201557L
Authority
SE
Sweden
Prior art keywords
competing
droplet
polymer
membranes
formation
Prior art date
Application number
SE8201557A
Other languages
Swedish (sv)
Other versions
SE454181B (en
Inventor
F Lim
Original Assignee
Damon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Damon Corp filed Critical Damon Corp
Publication of SE8201557L publication Critical patent/SE8201557L/en
Publication of SE454181B publication Critical patent/SE454181B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

A process for microencapsulating a core material and subsequently releasing the core material by selectively disrupting the membranes of the microcapsules involves the formation of a water-insoluble semipermeable membrane, e.g., around a droplet, through formation of multiple ionic salt bonds between a polyionic polymer in the droplet and a crosslinking polyionic polymer which possesses multiple ionic groups of opposite charge. The membrane is disrupted by exposing it to a solution of competing crosslinking multivalent (preferably di or trivalent) ions and to a solution of a competing polyionic polymer of the same charge as the polymer in the original droplet. The two competing reagents may be used in admixture. The competing reagents convert the membranes into a water-dispersible or soluble gel from which is then completely disrupted by exposure to a sequestering agent.
SE8201557A 1981-03-13 1982-03-12 SET TO SPLET SALT BRIDGES IN CAPSEL MEMBRANE FOR RELEASEING THE CONTENT, SEPARATELY LIVE CELLS SE454181B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24358481A 1981-03-13 1981-03-13

Publications (2)

Publication Number Publication Date
SE8201557L true SE8201557L (en) 1982-09-14
SE454181B SE454181B (en) 1988-04-11

Family

ID=22919328

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8201557A SE454181B (en) 1981-03-13 1982-03-12 SET TO SPLET SALT BRIDGES IN CAPSEL MEMBRANE FOR RELEASEING THE CONTENT, SEPARATELY LIVE CELLS

Country Status (11)

Country Link
JP (1) JPS57197031A (en)
BE (1) BE892477A (en)
CA (1) CA1184518A (en)
CH (1) CH651579A5 (en)
DE (1) DE3209045C2 (en)
DK (1) DK112382A (en)
FR (1) FR2501528A1 (en)
GB (1) GB2094750B (en)
IT (1) IT1150681B (en)
NO (1) NO158284C (en)
SE (1) SE454181B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD160393A3 (en) * 1980-11-14 1983-07-27 Horst Dautzenberg MICRO CAPSULES AND METHOD FOR THE PRODUCTION THEREOF
NO163060C (en) * 1981-03-13 1990-03-28 Damon Biotech Inc PROCEDURE FOR THE PREPARATION OF SUBSTANCES MADE BY LIVING CELLS PRODUCING INTERFERONES OR ANTIBODIES.
NO161446C (en) * 1981-03-13 1989-08-16 Damon Biotech Inc PROCEDURE FOR CULTING CELLS RELATED TO ANCHORING.
US4582799A (en) * 1983-04-15 1986-04-15 Damon Biotech, Inc. Process for recovering nonsecreted substances produced by cells
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
EP0127989A3 (en) * 1983-06-01 1986-03-26 Connaught Laboratories Limited Microencapsulation of living tissue and cells
IL72787A (en) * 1983-09-01 1987-12-31 Damon Biotech Inc Polyionic microencapsulation of viable cells
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
DE3575375D1 (en) * 1984-02-15 1990-02-22 Massachusetts Inst Technology ENCLOSURE METHOD AND SYSTEMS WITH ENCLOSED ACTIVE MATERIAL.
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
GB8500121D0 (en) * 1985-01-03 1985-02-13 Connaught Lab Microencapsulation of living cells
AU589438B2 (en) * 1985-08-26 1989-10-12 Hana Biologics, Inc. Transplantable artificial tissue and process
JPS62166891A (en) * 1986-01-20 1987-07-23 Snow Brand Milk Prod Co Ltd Production of useful substance by cell cultivation
US4952506A (en) * 1986-04-28 1990-08-28 Rohm And Haas Company Immobilization of nonanchorage-dependent cells
JPS6348039U (en) * 1986-09-12 1988-04-01
JPS6379587A (en) * 1986-09-22 1988-04-09 Saburo Senoo Base material for cultivating cell
US5069831A (en) * 1988-12-22 1991-12-03 The Mead Corporation Method for separation of microcapsules and preparation of printing inks
ES2107537T3 (en) 1991-04-25 1997-12-01 Univ Brown Res Found IMMUNO INSULATED BIOCOMPATIBLE VEHICLE IMPLANTABLE TO SUPPLY SELECTED THERAPEUTIC PRODUCTS.
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
IL102785A (en) * 1991-08-20 1998-06-15 Univ Leicester Method for removing protein from a water- soluble gum and a method of making biocompatible capsules using said gum
EP1151756B1 (en) * 1999-12-08 2007-02-28 Vercell Biotechnology BV Kit comprising polyacrylamide gel for forming a capsule in the tissue of a mammal organism and allogenic or xenogenous cells of an animal, method for therapy of oncological diseases and the diabetes mellitus
GB201408233D0 (en) 2014-05-09 2014-06-25 Austrianova Singapore Pte Ltd Use of polyanionic composition
JP7159334B2 (en) * 2018-09-28 2022-10-24 富士フイルム株式会社 CELL STRUCTURE, CELL STRUCTURE MANUFACTURING METHOD, CELL CULTURE METHOD, AND MICROCHANNEL
CN114504561B (en) * 2022-03-01 2023-08-11 陕西科技大学 Aqueous coating method for preparing drug osmotic pump preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129921C (en) * 1958-12-31
FR1542881A (en) * 1966-10-10 1968-10-18 Ncr Co Process for preparing tiny polymer-based capsules
CH573212A5 (en) * 1973-06-29 1976-03-15 Feller Marc Rech Tech Et Et Sc Delayed release agricultural formulations - of herbicide or insecticide absorbed on porous carrier and coed with isolating layer
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material

Also Published As

Publication number Publication date
BE892477A (en) 1982-07-01
DE3209045C2 (en) 1986-06-19
FR2501528A1 (en) 1982-09-17
NO158284C (en) 1988-08-17
CA1184518A (en) 1985-03-26
IT8220139A0 (en) 1982-03-12
DK112382A (en) 1982-09-14
DE3209045A1 (en) 1982-09-30
NO820795L (en) 1982-09-14
FR2501528B1 (en) 1984-06-15
JPS57197031A (en) 1982-12-03
JPS6152737B2 (en) 1986-11-14
CH651579A5 (en) 1985-09-30
IT1150681B (en) 1986-12-17
NO158284B (en) 1988-05-09
GB2094750A (en) 1982-09-22
GB2094750B (en) 1984-08-22
SE454181B (en) 1988-04-11

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