SE8104958L - AMINOTIOL DERIVATIVES, PREPARATION AND USE THEREOF, AND COMPOSITIONS CONTAINING SUCH DERIVATIVES - Google Patents

AMINOTIOL DERIVATIVES, PREPARATION AND USE THEREOF, AND COMPOSITIONS CONTAINING SUCH DERIVATIVES

Info

Publication number
SE8104958L
SE8104958L SE8104958A SE8104958A SE8104958L SE 8104958 L SE8104958 L SE 8104958L SE 8104958 A SE8104958 A SE 8104958A SE 8104958 A SE8104958 A SE 8104958A SE 8104958 L SE8104958 L SE 8104958L
Authority
SE
Sweden
Prior art keywords
alkyl
group
derivatives
phenyl
substituted
Prior art date
Application number
SE8104958A
Other languages
Swedish (sv)
Inventor
M Snyers
J Roba
G Lambelin
C Gillet
P Niebes
A Lenaers
Original Assignee
Continental Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma filed Critical Continental Pharma
Publication of SE8104958L publication Critical patent/SE8104958L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Derivatives of aminothiols having a number of therapeutic properties, e.g. vasodilating, antihypertensive, hypolipidaemiant, antithrombotic, antiarthritic, immodulatory and/or antimitotic properties of the general formula (I):- <IMAGE> wherein: R1 represents hydrogen or C1-10 alkyl; R2 represents hydrogen or C1-4 alkyl; R1 and R2 can form, with the adjacent carbon atoms, C3-8 to cycloalkyl; R3 represents hydrogen, C1-3 alkyl, C1-3 alkanoylthio, C1-3 alkyloxycarbonylthio, C1-10 alkylthio or a radical -(S)n-CR1R2-CH2-NR4R5, n being 1 or 2; R4 and R5, which can be identical or different, represent: hydrogen, C1-6 alkyl, possibly substituted by: a hydroxyl group, a carboxyl or a linear or branched C1-C2 alkoxycarbonyl group, a naphthyloxy, a phenyl, phenoxy, phenylthio or benzyloxy group optionally substituted by one, two or more halogen atoms such as chlorine, by one, two or more, C1-4 alkyl radicals, by one, two or more C1-4 alkyloxy radicals, a C1-4 alkoxy or alkylthio group, a C1-4 alkylamino group possibly substituted by a phenyl ring, a C1-6 alkylcarboxamido group possibly substituted by a phenyl or phenoxy group, a C3-8 cycloalkylcarboxamido group, C3-8 cycloalkyl, C3-16 alkenyl, C3-8 alkynyl, R4 and R5 can form with the adjacent nitrogen atom a heterocycle such as piperidine, pyrrolidine, morpholine, piperazine, possibly substituted in the 4 position by benzyl, C1-4 alkyl or phenyl which can itself be substituted by one, two or more halogen atoms such as fluorine and chlorine, C1, C2 or C3 alkyl radicals, C1, C2 or C3 alkoxy radicals; R3 and R4 can form a thiazolidine cycle optionally substituted in the 2 position by one or two C1, C2 or C3 alkyl groups or a thiazolidinone cycle; R1, R2, R3, R4 and R5 cannot simultaneously represent hydrogen, and non-toxic and pharmaceutically utilisable salts of these derivatives.
SE8104958A 1980-08-29 1981-08-21 AMINOTIOL DERIVATIVES, PREPARATION AND USE THEREOF, AND COMPOSITIONS CONTAINING SUCH DERIVATIVES SE8104958L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU82738A LU82738A1 (en) 1980-08-29 1980-08-29 DERIVATIVES OF AMINOTHIOLS, THEIR PREPARATION AND USE AS WELL AS COMPOSITIONS CONTAINING THESE DERIVATIVES

Publications (1)

Publication Number Publication Date
SE8104958L true SE8104958L (en) 1982-03-01

Family

ID=19729472

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8104958A SE8104958L (en) 1980-08-29 1981-08-21 AMINOTIOL DERIVATIVES, PREPARATION AND USE THEREOF, AND COMPOSITIONS CONTAINING SUCH DERIVATIVES

Country Status (18)

Country Link
JP (1) JPS5798255A (en)
AU (1) AU7465481A (en)
BE (1) BE890116A (en)
DE (1) DE3133293A1 (en)
DK (1) DK382281A (en)
ES (1) ES505037A0 (en)
FI (1) FI812640L (en)
FR (1) FR2489325A1 (en)
GB (1) GB2083036A (en)
GR (1) GR74348B (en)
IL (1) IL63664A0 (en)
IT (1) IT1137642B (en)
LU (1) LU82738A1 (en)
NL (1) NL8103993A (en)
NO (1) NO812944L (en)
PT (1) PT73593B (en)
SE (1) SE8104958L (en)
ZA (1) ZA815912B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8405896D0 (en) * 1984-03-07 1984-04-11 Sandoz Ltd Organic compounds
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2505870A (en) * 1947-05-09 1950-05-02 Phillips Petroleum Co Secondary and tertiary alkylthiol amines and their production
US3337625A (en) * 1961-09-18 1967-08-22 Lilly Co Eli Amino-acetylenic compounds
US3312732A (en) * 1962-02-28 1967-04-04 Monsanto Res Corp Aminoalkyl aminoalkanethiols
US3356730A (en) * 1964-11-25 1967-12-05 Monsanto Res Corp Mercaptoalkyl oxyalkyl amines
GB1138738A (en) * 1966-12-01 1969-01-01 Eastman Kodak Co Aziridine derivatives
US3622676A (en) * 1968-11-20 1971-11-23 Constance Anthony D Alonzo Smoking suppression
CA992105A (en) * 1970-03-26 1976-06-29 Exxon Research And Engineering Company Polythioethers formed by anionic ring opening of episulfides
BE789629A (en) * 1971-10-05 1973-04-03 Sandoz Sa NEW DERIVATIVES OF PLEUROMUTILINE, THEIR PREPARATION AND THERAPEUTIC APPLICATION
CH632906A5 (en) * 1976-08-09 1982-11-15 Givaudan & Cie Sa Use of bifunctional N,S-compounds as flavourings

Also Published As

Publication number Publication date
ZA815912B (en) 1982-08-25
PT73593B (en) 1982-11-10
ES8307735A1 (en) 1983-08-16
ES505037A0 (en) 1983-08-16
DE3133293A1 (en) 1982-04-08
PT73593A (en) 1981-09-01
FR2489325A1 (en) 1982-03-05
LU82738A1 (en) 1982-05-10
IT8123611A0 (en) 1981-08-24
IL63664A0 (en) 1981-11-30
GB2083036A (en) 1982-03-17
DK382281A (en) 1982-03-01
GR74348B (en) 1984-06-26
AU7465481A (en) 1982-03-04
NL8103993A (en) 1982-03-16
BE890116A (en) 1982-03-01
NO812944L (en) 1982-03-01
IT1137642B (en) 1986-09-10
FI812640L (en) 1982-03-01
JPS5798255A (en) 1982-06-18

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