SE8008721L - TRIFLUORMETYLFENYLBIS-biguanides - Google Patents

TRIFLUORMETYLFENYLBIS-biguanides

Info

Publication number
SE8008721L
SE8008721L SE8008721A SE8008721A SE8008721L SE 8008721 L SE8008721 L SE 8008721L SE 8008721 A SE8008721 A SE 8008721A SE 8008721 A SE8008721 A SE 8008721A SE 8008721 L SE8008721 L SE 8008721L
Authority
SE
Sweden
Prior art keywords
atoms
carbon atoms
alkyl radicals
formula
radicals
Prior art date
Application number
SE8008721A
Other languages
Swedish (sv)
Inventor
P S Juneja
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/669,930 external-priority patent/US4067962A/en
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of SE8008721L publication Critical patent/SE8008721L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C07C279/265—X and Y being nitrogen atoms, i.e. biguanides containing two or more biguanide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Confectionery (AREA)

Abstract

A composition for oral and/or dental care, e.g. in the form of a tooth cleaning agent or mouthwash or chewing gum, contains a vehicle for use in the oral cavity and antiplaque agent of the formula (1) <IMAGE> in which n is a number from 1 up to and including 4, X and X' are each an alkylene radical which contains 1-3 C atoms, z and z' are zero or one, R and R' are each hydrogen atoms, alkyl radicals with 1-12 C atoms or aralkyl radicals with 7-12 C atoms, and R2 and R2' are each hydrogen atoms or alkyl radicals with 1-2 C atoms, or a pharmacologically acceptable salt of a compound of the formula (1).

Claims (1)

1. Pat entkrav I. Bis-biguanidforening med den allmEnna formeln: R NHNH H' -- NH-C- N-(CH2)n-NHNHN - C CF3 dEr n Er ett tal frin 1 t. 111 4, X onvaddera betecknar en alky- lenradikal, som innehaller 1-3 kolatomer, z och z vardera Er 0 eller 1, R och R' vardera Er valda ur en grupp, hestEende an vEte, alkylradikaler med 1 till ca 12 kolatomer och aralkylradikaler med 7 till ca 12 kolatomer och dEr 02 och 0'2 vardera Er valda or en grupp, som boottir an vat, uen alkylradikaler Med 1-2 kolatomer, samt de farmaceutiskt godtagbara salterna darav.1. Claim claim I. Bis-biguanide compound of the general formula: R NHNH H '- NH-C- N- (CH2) n-NHNHN - C CF3 dEr n Er a number frin 1 t. 111 4, X den an alkylene radical containing 1-3 carbon atoms, z and z are each Er 0 or 1, R and R 'are each selected from a group consisting of hydrogen, alkyl radicals having 1 to about 12 carbon atoms and aralkyl radicals having 7 to about 12 carbon atoms and there are 02 and 0'2 each of which are selected from a group which is free of alkyl radicals having 1-2 carbon atoms and the pharmaceutically acceptable salts thereof.
SE8008721A 1975-08-01 1980-12-11 TRIFLUORMETYLFENYLBIS-biguanides SE8008721L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60124475A 1975-08-01 1975-08-01
US05/669,930 US4067962A (en) 1975-08-01 1976-03-24 Oral compositions containing trifluoromethyl phenyl bis-biguanides as antiplaque agents

Publications (1)

Publication Number Publication Date
SE8008721L true SE8008721L (en) 1980-12-11

Family

ID=27083824

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7608566A SE429923B (en) 1975-08-01 1976-07-29 ORAL COMPOSITION CONTAINING CERTAIN TRIFLUORMETHYLPHENYLBIS BIGUANIDES AS PLAQUETIC EFFECTS
SE8008721A SE8008721L (en) 1975-08-01 1980-12-11 TRIFLUORMETYLFENYLBIS-biguanides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7608566A SE429923B (en) 1975-08-01 1976-07-29 ORAL COMPOSITION CONTAINING CERTAIN TRIFLUORMETHYLPHENYLBIS BIGUANIDES AS PLAQUETIC EFFECTS

Country Status (13)

Country Link
JP (1) JPS5254036A (en)
AT (1) AT348682B (en)
CH (1) CH621938A5 (en)
DE (1) DE2633651A1 (en)
DK (1) DK343676A (en)
ES (1) ES450364A1 (en)
FR (1) FR2319336A1 (en)
GB (1) GB1549074A (en)
IE (1) IE43411B1 (en)
IT (1) IT1062647B (en)
LU (1) LU75517A1 (en)
NL (1) NL7608480A (en)
SE (2) SE429923B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4241491C2 (en) * 1991-12-12 1998-05-20 Mitsubishi Materials Corp Use of bisbiguanide compounds
US8287843B2 (en) 2003-06-23 2012-10-16 Colgate-Palmolive Company Antiplaque oral care compositions
WO2005000253A1 (en) 2003-06-23 2005-01-06 Colgate-Palmolive Company Stable dentifrice compositions

Also Published As

Publication number Publication date
NL7608480A (en) 1977-02-03
FR2319336A1 (en) 1977-02-25
SE429923B (en) 1983-10-10
FR2319336B1 (en) 1979-07-13
ATA566776A (en) 1978-07-15
DK343676A (en) 1977-02-02
JPS5254036A (en) 1977-05-02
ES450364A1 (en) 1977-08-16
SE7608566L (en) 1977-02-02
AT348682B (en) 1979-02-26
IE43411B1 (en) 1981-02-25
IE43411L (en) 1977-02-01
IT1062647B (en) 1984-10-20
LU75517A1 (en) 1977-04-20
CH621938A5 (en) 1981-03-13
GB1549074A (en) 1979-08-01
DE2633651A1 (en) 1977-02-17

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