SE8003122L - CHINAZOLINE DERIVATIVES WITH ANTIHYPERTENSIVE ACTIVITY - Google Patents
CHINAZOLINE DERIVATIVES WITH ANTIHYPERTENSIVE ACTIVITYInfo
- Publication number
- SE8003122L SE8003122L SE8003122A SE8003122A SE8003122L SE 8003122 L SE8003122 L SE 8003122L SE 8003122 A SE8003122 A SE 8003122A SE 8003122 A SE8003122 A SE 8003122A SE 8003122 L SE8003122 L SE 8003122L
- Authority
- SE
- Sweden
- Prior art keywords
- derivatives
- amino
- compounds
- piperazino
- antihypertensive activity
- Prior art date
Links
- 230000003276 anti-hypertensive effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- UDETZZKGDGINOX-UHFFFAOYSA-N [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(3,4-dihydro-2h-chromen-2-yl)methanone Chemical compound C1CC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 UDETZZKGDGINOX-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003246 quinazolines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A series of novel 4-amino-6,7-di(lower alkoxy)-2-(4-substituted piperazino)quinazoline derivatives have been prepared, including their pharmaceutically acceptable acid addition salts. These derivatives all possess a benzo-oxacycloalkanoyl moiety located at the 4-position of the piperazine ring. Such compounds are useful in therapy as highly potent antihypertensive agents. 4-Amino-2-[4-(chroman-2-carbonyl)piperazino]-6,7-dimethoxyquinazoline represents a typical and preferred member compound. Methods for preparing all these compounds from known starting materials are provided and the principal synthetic route leading to the desired final products is described in some detail.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7914431 | 1979-04-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8003122L true SE8003122L (en) | 1980-10-26 |
| SE435061B SE435061B (en) | 1984-09-03 |
Family
ID=10504770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8003122A SE435061B (en) | 1979-04-25 | 1980-04-24 | 4-AMINO-6,7-DIALCOXICINAZOLINE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS FOR TREATMENT OF HYPERTENSION |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US4279910A (en) |
| JP (1) | JPS55145684A (en) |
| KR (1) | KR830002567B1 (en) |
| AR (1) | AR224400A1 (en) |
| AT (1) | AT373596B (en) |
| BE (1) | BE882967A (en) |
| CA (1) | CA1132558A (en) |
| CH (1) | CH642076A5 (en) |
| CS (1) | CS209950B2 (en) |
| DD (1) | DD150202A5 (en) |
| DE (1) | DE3015676A1 (en) |
| DK (1) | DK121080A (en) |
| EG (1) | EG14651A (en) |
| ES (1) | ES490867A0 (en) |
| FI (1) | FI64592C (en) |
| FR (1) | FR2455042A1 (en) |
| GB (1) | GB2049683B (en) |
| GR (1) | GR68049B (en) |
| HU (1) | HU184747B (en) |
| IE (1) | IE49705B1 (en) |
| IL (1) | IL59900A (en) |
| IT (1) | IT1141490B (en) |
| LU (1) | LU82394A1 (en) |
| NL (1) | NL182563C (en) |
| NO (1) | NO152508C (en) |
| NZ (1) | NZ193511A (en) |
| PH (1) | PH15156A (en) |
| PL (1) | PL121470B1 (en) |
| PT (1) | PT71139A (en) |
| SE (1) | SE435061B (en) |
| SU (1) | SU915804A3 (en) |
| YU (1) | YU41709B (en) |
| ZA (1) | ZA802488B (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3511836A (en) * | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US3635979A (en) * | 1969-09-29 | 1972-01-18 | Pfizer | Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines |
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| US4001237A (en) * | 1976-02-18 | 1977-01-04 | Bristol-Myers Company | Oxazole, isoxazole, thiazole and isothiazole amides |
| US4140776A (en) * | 1977-09-16 | 1979-02-20 | Merck & Co., Inc. | N-pyrazinecarbonyl-N'-acylguanidines |
| GB2007656B (en) * | 1977-11-05 | 1982-05-19 | Pfizer Ltd | Therapeutic agents |
-
1980
- 1980-03-20 DK DK121080A patent/DK121080A/en not_active IP Right Cessation
- 1980-04-15 US US06/140,534 patent/US4279910A/en not_active Expired - Lifetime
- 1980-04-16 CS CS802656A patent/CS209950B2/en unknown
- 1980-04-19 GR GR61722A patent/GR68049B/el unknown
- 1980-04-22 EG EG80247A patent/EG14651A/en active
- 1980-04-23 NZ NZ193511A patent/NZ193511A/en unknown
- 1980-04-23 AR AR280773A patent/AR224400A1/en active
- 1980-04-23 FI FI801306A patent/FI64592C/en not_active IP Right Cessation
- 1980-04-23 IL IL59900A patent/IL59900A/en unknown
- 1980-04-23 AT AT0218980A patent/AT373596B/en not_active IP Right Cessation
- 1980-04-23 DE DE19803015676 patent/DE3015676A1/en not_active Ceased
- 1980-04-23 IT IT21598/80A patent/IT1141490B/en active
- 1980-04-23 LU LU82394A patent/LU82394A1/en unknown
- 1980-04-24 NL NLAANVRAGE8002387,A patent/NL182563C/en not_active IP Right Cessation
- 1980-04-24 BE BE0/200366A patent/BE882967A/en not_active IP Right Cessation
- 1980-04-24 DD DD80220686A patent/DD150202A5/en unknown
- 1980-04-24 SU SU802912149A patent/SU915804A3/en active
- 1980-04-24 ES ES490867A patent/ES490867A0/en active Granted
- 1980-04-24 CA CA350,598A patent/CA1132558A/en not_active Expired
- 1980-04-24 GB GB8013543A patent/GB2049683B/en not_active Expired
- 1980-04-24 YU YU1131/80A patent/YU41709B/en unknown
- 1980-04-24 NO NO801196A patent/NO152508C/en unknown
- 1980-04-24 ZA ZA00802488A patent/ZA802488B/en unknown
- 1980-04-24 CH CH317280A patent/CH642076A5/en not_active IP Right Cessation
- 1980-04-24 JP JP5485980A patent/JPS55145684A/en active Granted
- 1980-04-24 SE SE8003122A patent/SE435061B/en not_active IP Right Cessation
- 1980-04-24 FR FR8009235A patent/FR2455042A1/en active Granted
- 1980-04-24 IE IE827/80A patent/IE49705B1/en unknown
- 1980-04-24 HU HU801016A patent/HU184747B/en unknown
- 1980-04-24 PT PT71139A patent/PT71139A/en unknown
- 1980-04-24 PH PH23945A patent/PH15156A/en unknown
- 1980-04-25 KR KR1019800001676A patent/KR830002567B1/en active
- 1980-04-25 PL PL1980223755A patent/PL121470B1/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8003122-2 Effective date: 19900411 Format of ref document f/p: F |