SE8003122L - CHINAZOLINE DERIVATIVES WITH ANTIHYPERTENSIVE ACTIVITY - Google Patents

CHINAZOLINE DERIVATIVES WITH ANTIHYPERTENSIVE ACTIVITY

Info

Publication number
SE8003122L
SE8003122L SE8003122A SE8003122A SE8003122L SE 8003122 L SE8003122 L SE 8003122L SE 8003122 A SE8003122 A SE 8003122A SE 8003122 A SE8003122 A SE 8003122A SE 8003122 L SE8003122 L SE 8003122L
Authority
SE
Sweden
Prior art keywords
derivatives
amino
compounds
piperazino
antihypertensive activity
Prior art date
Application number
SE8003122A
Other languages
Swedish (sv)
Other versions
SE435061B (en
Inventor
S F Campbell
G Fiars
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10504770&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE8003122(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of SE8003122L publication Critical patent/SE8003122L/en
Publication of SE435061B publication Critical patent/SE435061B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/95Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A series of novel 4-amino-6,7-di(lower alkoxy)-2-(4-substituted piperazino)quinazoline derivatives have been prepared, including their pharmaceutically acceptable acid addition salts. These derivatives all possess a benzo-oxacycloalkanoyl moiety located at the 4-position of the piperazine ring. Such compounds are useful in therapy as highly potent antihypertensive agents. 4-Amino-2-[4-(chroman-2-carbonyl)piperazino]-6,7-dimethoxyquinazoline represents a typical and preferred member compound. Methods for preparing all these compounds from known starting materials are provided and the principal synthetic route leading to the desired final products is described in some detail.
SE8003122A 1979-04-25 1980-04-24 4-AMINO-6,7-DIALCOXICINAZOLINE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS FOR TREATMENT OF HYPERTENSION SE435061B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7914431 1979-04-25

Publications (2)

Publication Number Publication Date
SE8003122L true SE8003122L (en) 1980-10-26
SE435061B SE435061B (en) 1984-09-03

Family

ID=10504770

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8003122A SE435061B (en) 1979-04-25 1980-04-24 4-AMINO-6,7-DIALCOXICINAZOLINE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS FOR TREATMENT OF HYPERTENSION

Country Status (33)

Country Link
US (1) US4279910A (en)
JP (1) JPS55145684A (en)
KR (1) KR830002567B1 (en)
AR (1) AR224400A1 (en)
AT (1) AT373596B (en)
BE (1) BE882967A (en)
CA (1) CA1132558A (en)
CH (1) CH642076A5 (en)
CS (1) CS209950B2 (en)
DD (1) DD150202A5 (en)
DE (1) DE3015676A1 (en)
DK (1) DK121080A (en)
EG (1) EG14651A (en)
ES (1) ES490867A0 (en)
FI (1) FI64592C (en)
FR (1) FR2455042A1 (en)
GB (1) GB2049683B (en)
GR (1) GR68049B (en)
HU (1) HU184747B (en)
IE (1) IE49705B1 (en)
IL (1) IL59900A (en)
IT (1) IT1141490B (en)
LU (1) LU82394A1 (en)
NL (1) NL182563C (en)
NO (1) NO152508C (en)
NZ (1) NZ193511A (en)
PH (1) PH15156A (en)
PL (1) PL121470B1 (en)
PT (1) PT71139A (en)
SE (1) SE435061B (en)
SU (1) SU915804A3 (en)
YU (1) YU41709B (en)
ZA (1) ZA802488B (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3635979A (en) * 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4140776A (en) * 1977-09-16 1979-02-20 Merck & Co., Inc. N-pyrazinecarbonyl-N'-acylguanidines
GB2007656B (en) * 1977-11-05 1982-05-19 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
NO152508B (en) 1985-07-01
IT1141490B (en) 1986-10-01
IL59900A (en) 1983-11-30
ES8101588A1 (en) 1980-12-16
FR2455042A1 (en) 1980-11-21
DD150202A5 (en) 1981-08-19
IL59900A0 (en) 1980-06-30
NO152508C (en) 1985-10-09
GB2049683A (en) 1980-12-31
HU184747B (en) 1984-10-29
FI801306A (en) 1980-10-26
PL223755A1 (en) 1981-02-13
IT8021598A0 (en) 1980-04-23
EG14651A (en) 1985-03-31
JPS55145684A (en) 1980-11-13
AR224400A1 (en) 1981-11-30
CS209950B2 (en) 1981-12-31
BE882967A (en) 1980-10-24
JPS5738591B2 (en) 1982-08-16
AT373596B (en) 1984-02-10
PT71139A (en) 1980-05-01
NL182563C (en) 1988-04-05
KR830002758A (en) 1983-06-30
ZA802488B (en) 1981-08-26
GB2049683B (en) 1983-01-26
FI64592C (en) 1983-12-12
PL121470B1 (en) 1982-05-31
YU113180A (en) 1983-02-28
ATA218980A (en) 1983-06-15
SE435061B (en) 1984-09-03
NL8002387A (en) 1980-10-28
NO801196L (en) 1980-10-27
ES490867A0 (en) 1980-12-16
GR68049B (en) 1981-10-29
IE49705B1 (en) 1985-11-27
YU41709B (en) 1987-12-31
US4279910A (en) 1981-07-21
KR830002567B1 (en) 1983-11-14
NZ193511A (en) 1982-03-30
DK121080A (en) 1980-10-26
PH15156A (en) 1982-08-24
NL182563B (en) 1987-11-02
FI64592B (en) 1983-08-31
FR2455042B1 (en) 1983-05-20
CA1132558A (en) 1982-09-28
LU82394A1 (en) 1980-07-31
IE800827L (en) 1980-10-25
CH642076A5 (en) 1984-03-30
SU915804A3 (en) 1982-03-23
DE3015676A1 (en) 1980-11-13

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