SE8000545L - INTERMEDIATES FOR PROSTAGLAND INALOGS - Google Patents

INTERMEDIATES FOR PROSTAGLAND INALOGS

Info

Publication number
SE8000545L
SE8000545L SE8000545A SE8000545A SE8000545L SE 8000545 L SE8000545 L SE 8000545L SE 8000545 A SE8000545 A SE 8000545A SE 8000545 A SE8000545 A SE 8000545A SE 8000545 L SE8000545 L SE 8000545L
Authority
SE
Sweden
Prior art keywords
group
image
hydroxy
alkyl
formula
Prior art date
Application number
SE8000545A
Other languages
Swedish (sv)
Other versions
SE452157B (en
Inventor
H Wakatsuka
M Kawamure
T Okada
M Hayashi
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP655779A external-priority patent/JPS55100379A/en
Priority claimed from JP655679A external-priority patent/JPS55100378A/en
Priority claimed from JP655579A external-priority patent/JPS55100377A/en
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of SE8000545L publication Critical patent/SE8000545L/en
Publication of SE452157B publication Critical patent/SE452157B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the general formula:- <IMAGE> wherein Y represents <IMAGE> (in which R<4> represents H or a hydroxy- protecting group which is eliminated under basic conditions), Z represents <IMAGE> (in which R<5> represents H or a tetrahydropyran- 2-yl group), R<1> represents a formyl group, or a group of the formula -CH2OR<4>, R<2> represents a single bond, or a C1-5 alkylene group R<3> represents H, a C1-8 alkyl or C1-8 alkoxy group, or a C4-7 cycloakyl or C4-7 cycloalkyloxy group unsubstituted or substituted by at least one C1-8 alkyl group, or represents a phenyl or phenoxy group unsubstituted or substituted by at least one halogen atom, trifluoromethyl group or C1-4 alkyl group, with the proviso that, when R<2> represents a single bond, R<3> does not represent an alkoxy, cycloalkyloxy or phenoxy group, THP represents a tetrahydropyran-2-yl group, and the double bond between the carbon atoms in positions 13 and 14 is trans, with the provisos that, (i) when Z represents <IMAGE> (in which R<5> represents H), Y represents <IMAGE> (in which R<4> represents a hydroxy- protecting group) and R<1> represents a group of the formula -CH2OR<4> (in which R<4> represents a hydroxy-protecting group), and (ii) when Y represents <IMAGE> R<1> represents a formyl group, are useful as intermediates in the synthesis of therapeutically useful prostaglandin analogues.
SE8000545A 1979-01-25 1980-01-23 INTERMEDIATES FOR THE MANUFACTURING OF TRANS- DELTA? 722-PROSTAGLANDIN-E? 711-ANALOGS AND PROCEDURES FOR PRODUCING THESE SE452157B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP655779A JPS55100379A (en) 1979-01-25 1979-01-25 Preparation of prostaglandin analog and its intermediate
JP655679A JPS55100378A (en) 1979-01-25 1979-01-25 Intermediate for prostaglandin analog and its preparation
JP655579A JPS55100377A (en) 1979-01-25 1979-01-25 Intermediate for prostaglandim analog and its preparation

Publications (2)

Publication Number Publication Date
SE8000545L true SE8000545L (en) 1980-07-26
SE452157B SE452157B (en) 1987-11-16

Family

ID=27277218

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8000545A SE452157B (en) 1979-01-25 1980-01-23 INTERMEDIATES FOR THE MANUFACTURING OF TRANS- DELTA? 722-PROSTAGLANDIN-E? 711-ANALOGS AND PROCEDURES FOR PRODUCING THESE

Country Status (9)

Country Link
CA (1) CA1154441A (en)
CH (1) CH644360A5 (en)
DK (1) DK165111C (en)
FR (1) FR2447374A1 (en)
GB (1) GB2045745B (en)
HU (1) HU183068B (en)
IT (1) IT1149877B (en)
NL (1) NL8000428A (en)
SE (1) SE452157B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931296A (en) * 1972-12-29 1976-01-06 Masaki Hayashi Trans-Δ2 -prostaglandins
GB1540427A (en) * 1972-12-29 1979-02-14 Ono Pharmaceutical Co Prostaglandin analogues

Also Published As

Publication number Publication date
SE452157B (en) 1987-11-16
IT1149877B (en) 1986-12-10
GB2045745B (en) 1983-08-17
CH644360A5 (en) 1984-07-31
FR2447374A1 (en) 1980-08-22
DK165111C (en) 1993-03-01
FR2447374B1 (en) 1981-12-11
DK27780A (en) 1980-07-26
GB2045745A (en) 1980-11-05
DK165111B (en) 1992-10-12
CA1154441A (en) 1983-09-27
HU183068B (en) 1984-04-28
NL8000428A (en) 1980-07-29
IT8019399A0 (en) 1980-01-23

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