SE7910391L - ANTIBACTERIAL AGENTS - Google Patents

ANTIBACTERIAL AGENTS

Info

Publication number
SE7910391L
SE7910391L SE7910391A SE7910391A SE7910391L SE 7910391 L SE7910391 L SE 7910391L SE 7910391 A SE7910391 A SE 7910391A SE 7910391 A SE7910391 A SE 7910391A SE 7910391 L SE7910391 L SE 7910391L
Authority
SE
Sweden
Prior art keywords
compounds
easily removable
antibacterial agents
group
removable ester
Prior art date
Application number
SE7910391A
Other languages
Swedish (sv)
Other versions
SE448995B (en
Inventor
M Menard
A Martel
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE7910391L publication Critical patent/SE7910391L/en
Publication of SE448995B publication Critical patent/SE448995B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00Compounds containing azido groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/10Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568Four-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

This invention relates to phosphorane compounds of the formula <IMG> wherein Y is hydrogen, ethyl or hydroxyethyl, Q is phenyl or (lower) alkyl, R" is an easily removable ester group and X represents certain organic substituents. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3- position is protected by an easily removable ester protecting group. The compounds of the present invention are of use as intermediates in the preparation of penem compounds having potent antibacterial activity.
SE7910391A 1978-12-18 1979-12-17 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM SOCIETIES AND PROCEDURES FOR PREPARING THEREOF SE448995B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96866378A 1978-12-18 1978-12-18

Publications (2)

Publication Number Publication Date
SE7910391L true SE7910391L (en) 1981-06-18
SE448995B SE448995B (en) 1987-03-30

Family

ID=25514601

Family Applications (5)

Application Number Title Priority Date Filing Date
SE7910391A SE448995B (en) 1978-12-18 1979-12-17 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM SOCIETIES AND PROCEDURES FOR PREPARING THEREOF
SE7910390A SE454779B (en) 1978-12-18 1979-12-17 2,6-DISUBSTITUTED PENEM SOCIETIES, PROCEDURES FOR PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION THEREOF WITH ANTIBACTERIAL EFFECT
SE8405719A SE461395B (en) 1978-12-18 1984-11-14 4- (2'-AZIDOETOXIACETYLTIO) -1- (2 '-TRIFENYLFOSFORANYLIDEN-2 "-acetate) -2-azetidinones
SE8405812A SE8405812D0 (en) 1978-12-18 1984-11-19 INTERMEDIATES FOR THE PREPARATION OF NEW 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM COMPOUNDS
SE8405813A SE464027B (en) 1978-12-18 1984-11-19 INTERMEDIATES FOR THE PREPARATION OF NEW 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM SOCIETIES

Family Applications After (4)

Application Number Title Priority Date Filing Date
SE7910390A SE454779B (en) 1978-12-18 1979-12-17 2,6-DISUBSTITUTED PENEM SOCIETIES, PROCEDURES FOR PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION THEREOF WITH ANTIBACTERIAL EFFECT
SE8405719A SE461395B (en) 1978-12-18 1984-11-14 4- (2'-AZIDOETOXIACETYLTIO) -1- (2 '-TRIFENYLFOSFORANYLIDEN-2 "-acetate) -2-azetidinones
SE8405812A SE8405812D0 (en) 1978-12-18 1984-11-19 INTERMEDIATES FOR THE PREPARATION OF NEW 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM COMPOUNDS
SE8405813A SE464027B (en) 1978-12-18 1984-11-19 INTERMEDIATES FOR THE PREPARATION OF NEW 2-SUBSTITUTED AND 2,6-DISUBSTITUTED PENEM SOCIETIES

Country Status (13)

Country Link
JP (1) JPS60222486A (en)
AU (4) AU541717B2 (en)
CA (2) CA1286661C (en)
CH (2) CH643846A5 (en)
DK (5) DK533879A (en)
ES (1) ES8101594A1 (en)
FI (2) FI69845C (en)
GR (2) GR81420B (en)
IE (3) IE50597B1 (en)
IL (2) IL58576A (en)
SE (5) SE448995B (en)
YU (4) YU43628B (en)
ZA (2) ZA796813B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8509180D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
US4826832A (en) * 1986-05-06 1989-05-02 Ciba-Geigy Corporation Penen compounds
DE69629152T2 (en) * 1995-02-17 2004-07-08 Daiichi Suntory Pharma Co., Ltd. Penem derivatives and anti-microbial agents containing them
KR20000076105A (en) 1998-01-13 2000-12-26 도리이 신이찌로 Antibacterial composition for topical administration containing antibiotics
JP2005239696A (en) 2004-01-30 2005-09-08 Daiichi Suntory Pharma Co Ltd Medicinal hard capsule preparation blended with inorganic substance
CN112746066B (en) * 2021-01-25 2023-10-31 洛阳华荣生物技术有限公司 L-lysine decarboxylase mutant and application thereof

Also Published As

Publication number Publication date
SE461395B (en) 1990-02-12
DK237690A (en) 1990-10-01
YU43628B (en) 1989-10-31
SE8405812L (en) 1984-11-19
SE8405719L (en) 1984-11-14
DK237690D0 (en) 1990-10-01
YU43280B (en) 1989-06-30
JPS60222486A (en) 1985-11-07
YU307679A (en) 1983-02-28
DK135291A (en) 1991-07-15
DK161520C (en) 1991-12-23
IE49876B1 (en) 1986-01-08
GR74491B (en) 1984-06-28
FI67853C (en) 1985-06-10
DK161520B (en) 1991-07-15
CH643846A5 (en) 1984-06-29
ES487034A0 (en) 1980-12-16
IL58576A0 (en) 1980-01-31
YU215382A (en) 1983-06-30
YU215782A (en) 1983-06-30
SE8405719D0 (en) 1984-11-14
SE8405812D0 (en) 1984-11-19
AU541717B2 (en) 1985-01-17
SE7910390L (en) 1981-06-18
ZA796812B (en) 1981-05-27
ZA796813B (en) 1981-05-27
SE8405813D0 (en) 1984-11-19
AU5378779A (en) 1980-08-28
SE8405813L (en) 1984-11-19
DK236590A (en) 1990-10-01
IE49877B1 (en) 1986-01-08
YU276079A (en) 1983-02-28
SE454779B (en) 1988-05-30
CH643265A5 (en) 1984-05-30
SE464027B (en) 1991-02-25
DK533879A (en) 1980-06-19
AU3288484A (en) 1985-03-07
DK236590D0 (en) 1990-10-01
AU563015B2 (en) 1987-06-25
FI69845B (en) 1985-12-31
SE448995B (en) 1987-03-30
DK533779A (en) 1980-06-19
FI67853B (en) 1985-02-28
YU43464B (en) 1989-08-31
FI793903A (en) 1980-06-19
GR81420B (en) 1984-12-11
CA1286661C (en) 1991-07-23
IE50597B1 (en) 1986-05-28
IE852246L (en) 1980-06-18
CA1268183A (en) 1990-04-24
FI793905A (en) 1980-06-19
IE851853L (en) 1980-06-18
DK161970C (en) 1992-02-03
AU557545B2 (en) 1986-12-24
YU42125B (en) 1988-04-30
IE792462L (en) 1980-06-18
AU3240884A (en) 1984-12-13
AU539983B2 (en) 1984-10-25
IL58804A0 (en) 1980-02-29
DK161970B (en) 1991-09-02
ES8101594A1 (en) 1980-12-16
AU5371079A (en) 1980-06-26
FI69845C (en) 1986-05-26
DK135291D0 (en) 1991-07-15
IL58576A (en) 1985-12-31
IL58804A (en) 1986-03-31

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