SE7713377L - INTERMEDIATE FOR THE PREPARATION OF 6,7-DIMETOXY-4-AMINO-2- / 4- (2-FUROYL) -1-PIPERAZINYL / CHINAZOLINE WITH BLOOD PRESSURE-LOWING EFFECT - Google Patents

INTERMEDIATE FOR THE PREPARATION OF 6,7-DIMETOXY-4-AMINO-2- / 4- (2-FUROYL) -1-PIPERAZINYL / CHINAZOLINE WITH BLOOD PRESSURE-LOWING EFFECT

Info

Publication number
SE7713377L
SE7713377L SE7713377A SE7713377A SE7713377L SE 7713377 L SE7713377 L SE 7713377L SE 7713377 A SE7713377 A SE 7713377A SE 7713377 A SE7713377 A SE 7713377A SE 7713377 L SE7713377 L SE 7713377L
Authority
SE
Sweden
Prior art keywords
furoyl
formula
dimethoxy
dimetoxy
chinazoline
Prior art date
Application number
SE7713377A
Other languages
Swedish (sv)
Other versions
SE424993B (en
Inventor
E J Honkanen
A K Pippuri
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Publication of SE7713377L publication Critical patent/SE7713377L/en
Publication of SE424993B publication Critical patent/SE424993B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Anovel benzonitrile, namely 3,4-dimethoxy-6-¢4-(2-furoyl)-1-piper-azinylthiocarbamide! benzonitrile is provided herein. It may be prepared by carrying out one of the following reaction, namely (a) reacting 3,4-dimethoxy-6-aminobenzonitrile having the formula (IV) with thiophosgene, to form 3,4-dimethoxy-6-isothiocyanatobenzonitrile having the formula (V) and then reacting compound (V) with 1-(2-furoyl)piperazine having the formula (VI) or (b) reacting 1-(2-furoyl)piperazine (Formula VI) with thiophosgene to form 4-(2-furoyl)-piperazinylthiocarbonyl chloride having the formula (VII ) and then reacting compound (VII) with 3,4-dimethoxy-6-amlnobenzonitrile(Formula (IV). The product is an intermediate in the production of the anthibypertensive drug prazosine by a process in which the formation of the quinazoline ring of prazosine occurs within the molecule.
SE7713377A 1976-12-15 1977-11-25 INTERMEDIATE FOR THE PREPARATION OF 6,7-DIMETOXY-4-AMINO-2- / 4- (2-FUROYL) -1-PIPERAZINYL / CHINAZOLINE WITH ANTI-BLOOD PRESSURE EFFECT SE424993B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI763614A FI58124C (en) 1976-12-15 1976-12-15 NY MELLANPROTUKT 3,4-DIMETOXY-6- (4- (2-FUROYL) -1-PIPERAZINYLTHOUREA) -BENONITRIL FOR FRAMSTAELLNING AV 6,7-DIMETOXY-4-AMINO-2- (4- (2-FUROYL) -1 -PIPERAZINYL) QUINAZOLINE WITH BLODTRYCKSSAENKANDE VERKAN

Publications (2)

Publication Number Publication Date
SE7713377L true SE7713377L (en) 1978-06-16
SE424993B SE424993B (en) 1982-08-23

Family

ID=8510504

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7713377A SE424993B (en) 1976-12-15 1977-11-25 INTERMEDIATE FOR THE PREPARATION OF 6,7-DIMETOXY-4-AMINO-2- / 4- (2-FUROYL) -1-PIPERAZINYL / CHINAZOLINE WITH ANTI-BLOOD PRESSURE EFFECT

Country Status (17)

Country Link
JP (1) JPS5387375A (en)
AT (1) AT358047B (en)
BE (1) BE861822A (en)
CA (1) CA1102332A (en)
CH (1) CH630624A5 (en)
CS (1) CS197312B2 (en)
DD (1) DD134226A1 (en)
DE (1) DE2755638A1 (en)
DK (1) DK145822C (en)
FI (1) FI58124C (en)
HU (1) HU174048B (en)
NL (1) NL7713703A (en)
NO (1) NO146239C (en)
PL (1) PL106201B1 (en)
SE (1) SE424993B (en)
SU (1) SU923370A3 (en)
ZA (1) ZA777222B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI67699C (en) * 1979-01-31 1985-05-10 Orion Yhtymae Oy PROCEDURE FOR THE FRAMSTATION OF AV 6,7-DIMETOXY-4-AMINO-2- (4- (2-FUROYL) -1-PIPERAZINYL) QUINAZOLINE HYDROCHLORIDE WITH BLODTRYCKSSAENKANDE VERKAN

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935213A (en) * 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives

Also Published As

Publication number Publication date
DE2755638A1 (en) 1978-06-22
SU923370A3 (en) 1982-04-23
NO146239B (en) 1982-05-18
JPS6225145B2 (en) 1987-06-01
ZA777222B (en) 1978-09-27
CS197312B2 (en) 1980-04-30
FI58124B (en) 1980-08-29
DD134226A1 (en) 1979-02-14
NO774263L (en) 1978-06-16
DK145822C (en) 1983-08-29
JPS5387375A (en) 1978-08-01
CH630624A5 (en) 1982-06-30
ATA867177A (en) 1980-01-15
HU174048B (en) 1979-10-28
FI763614A (en) 1978-06-16
PL202898A1 (en) 1978-08-28
DK558377A (en) 1978-06-16
CA1102332A (en) 1981-06-02
NL7713703A (en) 1978-06-19
AT358047B (en) 1980-08-11
PL106201B1 (en) 1979-12-31
NO146239C (en) 1982-08-25
BE861822A (en) 1978-03-31
FI58124C (en) 1980-12-10
SE424993B (en) 1982-08-23
DK145822B (en) 1983-03-14

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