SE7708626L - METHODS OF PREPARING OXIMIN DERIVATIVES OF 3-CARBAMOYLOXIMETHYL-7-AMINOTIAZOLYL-ACETAMIDOCEFALOSPORANIC ACID - Google Patents

METHODS OF PREPARING OXIMIN DERIVATIVES OF 3-CARBAMOYLOXIMETHYL-7-AMINOTIAZOLYL-ACETAMIDOCEFALOSPORANIC ACID

Info

Publication number
SE7708626L
SE7708626L SE7708626A SE7708626A SE7708626L SE 7708626 L SE7708626 L SE 7708626L SE 7708626 A SE7708626 A SE 7708626A SE 7708626 A SE7708626 A SE 7708626A SE 7708626 L SE7708626 L SE 7708626L
Authority
SE
Sweden
Prior art keywords
acid
oximin
carbamoyloximethyl
aminotiazolyl
acetamidocefalosporanic
Prior art date
Application number
SE7708626A
Other languages
Swedish (sv)
Inventor
M Vignau
A Lutz
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE7708626L publication Critical patent/SE7708626L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The syn isomers of the compounds of formula: <IMAGE> , in which R1 represents a saturated or unsaturated C1-C4 alkyl and A represents hydrogen or one equivalent of an alkali metal or alkaline-earth metal or of an amine organic base, are prepared from the syn isomers of the corresponding compounds in which the amino group of the thiazolyl radical is substituted by a group which can be removed by acid hydrolysis or by hydrogenolysis, or by a chloroacetyl group; in the first case, an acid hydrolysis or a hydrogenolysis is carried out, in the second case treatment is carried out with thiourea. The compounds obtained have antibacterial properties; they can be used in the treatment of infectious diseases, especially of staphylococcias and of colibacilloses.
SE7708626A 1976-08-20 1977-07-27 METHODS OF PREPARING OXIMIN DERIVATIVES OF 3-CARBAMOYLOXIMETHYL-7-AMINOTIAZOLYL-ACETAMIDOCEFALOSPORANIC ACID SE7708626L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7625326A FR2361895A1 (en) 1976-08-20 1976-08-20 NEW OXIMES DERIVED FROM 3-CARBAMOYLOXYMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
SE7708626L true SE7708626L (en) 1978-02-21

Family

ID=9177033

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7708626A SE7708626L (en) 1976-08-20 1977-07-27 METHODS OF PREPARING OXIMIN DERIVATIVES OF 3-CARBAMOYLOXIMETHYL-7-AMINOTIAZOLYL-ACETAMIDOCEFALOSPORANIC ACID

Country Status (18)

Country Link
JP (1) JPS5325595A (en)
AT (1) AT357671B (en)
AU (1) AU510300B2 (en)
BE (1) BE857933A (en)
CH (1) CH626088A5 (en)
DE (1) DE2737504A1 (en)
DK (1) DK369677A (en)
ES (1) ES461764A1 (en)
FR (1) FR2361895A1 (en)
GB (1) GB1584398A (en)
IE (1) IE45865B1 (en)
IL (1) IL52709A (en)
LU (1) LU77993A1 (en)
NL (1) NL7709258A (en)
PT (1) PT66944B (en)
SE (1) SE7708626L (en)
SU (1) SU700065A3 (en)
ZA (1) ZA775039B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2367756B1 (en) * 1976-04-12 1985-07-05 Fujisawa Pharmaceutical Co 2-ALCOXYAMINO-2- (AMINO-1,3-THIAZOLYL) ACETICS DERIVATIVES AND THEIR USE
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
SE445350B (en) * 1978-04-14 1986-06-16 Roussel Uclaf OXIMO DERIVATIVES OF 3-AZIDOMETHYL-7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID AND ITS USE AS ANTIBIOTICS
IL61458A0 (en) * 1979-12-07 1980-12-31 Erba Farmitalia N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them
FR2475043A2 (en) * 1980-02-06 1981-08-07 Roussel Uclaf Amino:thiazolyl hydroxy:imino acetic ester(s) - protected on the amino gp. are intermediates for cephalosporanic acid antibiotics
US4560683A (en) * 1982-06-30 1985-12-24 Glaxo Group Limited Cephalosporin antibiotics
JPS60190783A (en) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk Cephem compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds

Also Published As

Publication number Publication date
AU510300B2 (en) 1980-06-19
AU2806277A (en) 1979-02-22
ZA775039B (en) 1978-09-27
IE45865B1 (en) 1982-12-15
GB1584398A (en) 1981-02-11
FR2361895B1 (en) 1978-12-15
CH626088A5 (en) 1981-10-30
IE45865L (en) 1978-02-20
AT357671B (en) 1980-07-25
FR2361895A1 (en) 1978-03-17
ES461764A1 (en) 1978-09-01
PT66944B (en) 1979-11-12
DK369677A (en) 1978-02-21
JPS5325595A (en) 1978-03-09
DE2737504A1 (en) 1978-02-23
PT66944A (en) 1977-09-01
IL52709A (en) 1981-01-30
ATA601677A (en) 1979-12-15
BE857933A (en) 1978-02-20
IL52709A0 (en) 1977-10-31
LU77993A1 (en) 1978-04-27
SU700065A3 (en) 1979-11-25
NL7709258A (en) 1978-02-22

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