SE7702250L - WAY TO PRODUCE NEW HALOGEN DERIVATIVES IN THE 16ALFA-METHYL PREGNANCE - Google Patents

WAY TO PRODUCE NEW HALOGEN DERIVATIVES IN THE 16ALFA-METHYL PREGNANCE

Info

Publication number
SE7702250L
SE7702250L SE7702250A SE7702250A SE7702250L SE 7702250 L SE7702250 L SE 7702250L SE 7702250 A SE7702250 A SE 7702250A SE 7702250 A SE7702250 A SE 7702250A SE 7702250 L SE7702250 L SE 7702250L
Authority
SE
Sweden
Prior art keywords
methyl
pregnance
16alfa
way
produce new
Prior art date
Application number
SE7702250A
Other languages
Unknown language ( )
Swedish (sv)
Inventor
J G Teutsch
G Costerousse
R Deraedt
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE7702250L publication Critical patent/SE7702250L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1530975 9,11 - Dihalo - 16 - methyl steroids ROUSSEL UCLAF 2 March 1977 [2 March 1976] 08713/77 Heading C2U The invention comprises compounds of formula (wherein L is H or C 1-18 acyl, and either X is Cl or Br and Y is Cl, or X is Cl and Y is F); and their preparation from the corresponding 9(11)- enes by halogenation, e.g. with an N-X-succinimide or -acetamide in conjunction with HY or LiY, optionally followed by acylation/deacylation interconversions at C-21. Topical anti-inflammatory compositions comprise a compound I and a carrier.
SE7702250A 1976-03-02 1977-03-01 WAY TO PRODUCE NEW HALOGEN DERIVATIVES IN THE 16ALFA-METHYL PREGNANCE SE7702250L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7605854A FR2342738A1 (en) 1976-03-02 1976-03-02 NEW HALOGEN DERIVATIVES OF THE 16A-METHYL PREGNANE SERIES

Publications (1)

Publication Number Publication Date
SE7702250L true SE7702250L (en) 1977-09-03

Family

ID=9169832

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7702250A SE7702250L (en) 1976-03-02 1977-03-01 WAY TO PRODUCE NEW HALOGEN DERIVATIVES IN THE 16ALFA-METHYL PREGNANCE

Country Status (16)

Country Link
JP (1) JPS52106855A (en)
AT (1) AT355237B (en)
AU (1) AU509948B2 (en)
BE (1) BE851944A (en)
CA (1) CA1082170A (en)
CH (1) CH619969A5 (en)
DE (1) DE2709078C2 (en)
DK (1) DK156401C (en)
FR (1) FR2342738A1 (en)
GB (1) GB1530975A (en)
IE (1) IE44866B1 (en)
LU (1) LU76867A1 (en)
NL (1) NL7702166A (en)
PT (1) PT66261B (en)
SE (1) SE7702250L (en)
ZA (1) ZA771078B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462443A1 (en) * 1979-07-26 1981-02-13 Roussel Uclaf NEW HALOGENIC DERIVATIVE OF THE 16A-METHYL PREGNANE SERIES, PREPARATION METHOD AND APPLICATION AS MEDICINE
FR2533928A1 (en) * 1982-10-05 1984-04-06 Roussel Uclaf NOVEL DICHLORIC DERIVATIVES OF THE 16A-METHYL PREGNANE SERIES, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS
DE4433374A1 (en) * 1994-09-20 1996-03-21 Hoechst Ag 17-deoxi-corticosteroid-21- / O / -carboxylic acid ester, process for their preparation and medicaments containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928301A (en) * 1958-06-20 1963-06-12 Scherico Ltd 9, 11-dihalogeno steroids
US3049554A (en) * 1959-06-01 1962-08-14 Schering Corp 9, 11-dihalogeno-3, 20-diketopregnanes and processes for their manufacture

Also Published As

Publication number Publication date
ATA136577A (en) 1979-07-15
DE2709078A1 (en) 1977-09-08
JPS52106855A (en) 1977-09-07
AU2280877A (en) 1978-09-07
FR2342738B1 (en) 1979-10-12
DK156401C (en) 1990-01-08
DK156401B (en) 1989-08-14
CH619969A5 (en) 1980-10-31
IE44866B1 (en) 1982-04-21
AU509948B2 (en) 1980-06-05
PT66261B (en) 1979-01-17
GB1530975A (en) 1978-11-01
LU76867A1 (en) 1977-09-26
CA1082170A (en) 1980-07-22
BE851944A (en) 1977-09-01
ZA771078B (en) 1978-04-26
FR2342738A1 (en) 1977-09-30
IE44866L (en) 1977-09-02
JPS6150960B2 (en) 1986-11-06
NL7702166A (en) 1977-09-06
DK88277A (en) 1977-09-03
PT66261A (en) 1977-04-01
DE2709078C2 (en) 1986-09-11
AT355237B (en) 1980-02-25

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