SE7514550L - PROCEDURE FOR THE PREPARATION OF 3-METHYLENCEFAM SULFOXIDES AND FOR THIS PROCEDURE AZETIDINONE SULFINYL COMPOUNDS - Google Patents
PROCEDURE FOR THE PREPARATION OF 3-METHYLENCEFAM SULFOXIDES AND FOR THIS PROCEDURE AZETIDINONE SULFINYL COMPOUNDSInfo
- Publication number
- SE7514550L SE7514550L SE7514550A SE7514550A SE7514550L SE 7514550 L SE7514550 L SE 7514550L SE 7514550 A SE7514550 A SE 7514550A SE 7514550 A SE7514550 A SE 7514550A SE 7514550 L SE7514550 L SE 7514550L
- Authority
- SE
- Sweden
- Prior art keywords
- procedure
- compounds
- friedel
- preparation
- bronsted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
Abstract
3-Methylenecepham 1-sulphoxides of the formula <IMAGE> in which the substituents are defined in Claim 1 are prepared. These compounds are prepared by bringing about ring closure in a corresponding sulphinylazetidinone of the formula <IMAGE> in which X is chlorine or bromine, an alcohol or thioalcohol residue, an ester or a thioester residue, or an amino radical. If X is chlorine or bromine, the compound II is reacted with a Friedel-Crafts catalyst of the Lewis acid type, with a Friedel-Crafts catalyst of the Bronsted protonic acid type or with a metathetical cation former in a dry inert organic solvent, or is dissolved in an organic Bronsted acid. If X in compounds II is an alcohol, thioalcohol, ester or thioester residue or an amino radical, reaction is carried out with a Friedel-Crafts catalyst of the Bronsted protonic acid type in a dry inert organic solvent, or the compound is dissolved in an organic Bronsted acid. The resulting compounds can be used for the preparation of cephem antibiotics.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53628074A | 1974-12-24 | 1974-12-24 | |
US63273375A | 1975-11-19 | 1975-11-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7514550L true SE7514550L (en) | 1976-06-25 |
SE431547B SE431547B (en) | 1984-02-13 |
Family
ID=27065082
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7514550A SE431547B (en) | 1974-12-24 | 1975-12-22 | PROCEDURE FOR THE PREPARATION OF 3-METHYLENCEFAM SULPHOXIDES |
SE7906899A SE444810B (en) | 1974-12-24 | 1979-08-17 | SULFINYAZETIDINONE COMPOUNDS FOR USING THE PREPARATION OF 3-METHYLENCEFAMSULPHOXIDES |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7906899A SE444810B (en) | 1974-12-24 | 1979-08-17 | SULFINYAZETIDINONE COMPOUNDS FOR USING THE PREPARATION OF 3-METHYLENCEFAMSULPHOXIDES |
Country Status (25)
Country | Link |
---|---|
JP (1) | JPS606960B2 (en) |
AR (1) | AR220505A1 (en) |
AT (1) | AT341672B (en) |
AU (1) | AU503202B2 (en) |
BE (1) | BE837041A (en) |
BG (2) | BG27236A3 (en) |
CA (1) | CA1056372A (en) |
CH (3) | CH625528A5 (en) |
CS (1) | CS191291B2 (en) |
DD (2) | DD130933A5 (en) |
DE (1) | DE2556045A1 (en) |
DK (1) | DK157137C (en) |
ES (2) | ES443829A1 (en) |
FR (2) | FR2333804A1 (en) |
GB (1) | GB1536288A (en) |
GR (1) | GR59922B (en) |
HU (2) | HU175226B (en) |
IE (1) | IE42190B1 (en) |
IL (1) | IL48565A (en) |
NL (1) | NL182880C (en) |
PL (2) | PL113883B1 (en) |
RO (2) | RO74273A (en) |
SE (2) | SE431547B (en) |
SU (1) | SU799667A3 (en) |
YU (2) | YU324875A (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4289695A (en) * | 1978-11-13 | 1981-09-15 | Eli Lilly And Company | Process for preparing 2-chlorosulfinylazetidinones |
US4190724A (en) * | 1978-11-13 | 1980-02-26 | Eli Lilly And Company | Process for 3-exomethylenecepham sulfoxides |
GB2099817B (en) * | 1981-04-10 | 1985-05-15 | Otsuka Kagaku Yakuhin | Azetidinone derivatives and process for the preparation of the same |
US4436596A (en) * | 1982-11-16 | 1984-03-13 | Eli Lilly And Company | N-Substituted-2-(R)-(sulfinic acid)-3-(S)-(acylamido)-4-oxo-azetidines and process |
DE4230053A1 (en) * | 1992-09-08 | 1994-03-10 | Pliva Handels Gmbh | 4-oxo-azetidine-2-sulfonic acid amides and their salts, process for their preparation and their use |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3843682A (en) * | 1972-05-15 | 1974-10-22 | Lilly Co Eli | 2-chlorosulfinyl-3-imido-azetedin-4-ones |
-
1975
- 1975-11-27 CA CA240,644A patent/CA1056372A/en not_active Expired
- 1975-11-27 GR GR49473A patent/GR59922B/en unknown
- 1975-11-28 IL IL48565A patent/IL48565A/en unknown
- 1975-11-28 AU AU87084/75A patent/AU503202B2/en not_active Expired
- 1975-11-28 IE IE2596/75A patent/IE42190B1/en unknown
- 1975-12-12 DE DE19752556045 patent/DE2556045A1/en active Granted
- 1975-12-16 CH CH1630475A patent/CH625528A5/en not_active IP Right Cessation
- 1975-12-17 DD DD7500198426A patent/DD130933A5/en unknown
- 1975-12-17 DD DD190224A patent/DD124985A5/xx unknown
- 1975-12-18 GB GB51980/75A patent/GB1536288A/en not_active Expired
- 1975-12-19 YU YU03248/75A patent/YU324875A/en unknown
- 1975-12-22 DK DK585875A patent/DK157137C/en not_active IP Right Cessation
- 1975-12-22 JP JP50153926A patent/JPS606960B2/en not_active Expired
- 1975-12-22 SE SE7514550A patent/SE431547B/en not_active IP Right Cessation
- 1975-12-23 HU HU75EI686A patent/HU175226B/en unknown
- 1975-12-23 SU SU752301511A patent/SU799667A3/en active
- 1975-12-23 BE BE1007103A patent/BE837041A/en not_active IP Right Cessation
- 1975-12-23 PL PL1975212224A patent/PL113883B1/en unknown
- 1975-12-23 AT AT980475A patent/AT341672B/en not_active IP Right Cessation
- 1975-12-23 CS CS758835A patent/CS191291B2/en unknown
- 1975-12-23 AR AR261750A patent/AR220505A1/en active
- 1975-12-23 HU HU75EI662A patent/HU177431B/en unknown
- 1975-12-23 PL PL1975185927A patent/PL114521B1/en unknown
- 1975-12-23 ES ES443829A patent/ES443829A1/en not_active Expired
- 1975-12-24 RO RO7594622A patent/RO74273A/en unknown
- 1975-12-24 FR FR7539714A patent/FR2333804A1/en active Granted
- 1975-12-24 BG BG7531908A patent/BG27236A3/en unknown
- 1975-12-24 RO RO7584303A patent/RO68478A/en unknown
- 1975-12-24 BG BG7536782A patent/BG31072A4/en unknown
- 1975-12-24 NL NLAANVRAGE7515069,A patent/NL182880C/en not_active IP Right Cessation
-
1976
- 1976-05-04 FR FR7613230A patent/FR2300080A1/en active Granted
-
1977
- 1977-04-15 ES ES457884A patent/ES457884A1/en not_active Expired
-
1979
- 1979-08-17 SE SE7906899A patent/SE444810B/en not_active IP Right Cessation
-
1980
- 1980-11-21 CH CH862880A patent/CH626604A5/en not_active IP Right Cessation
-
1981
- 1981-04-24 CH CH271381A patent/CH628620A5/en not_active IP Right Cessation
- 1981-08-26 YU YU02064/81A patent/YU206481A/en unknown
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