SE7409777L - - Google Patents

Info

Publication number
SE7409777L
SE7409777L SE7409777A SE7409777A SE7409777L SE 7409777 L SE7409777 L SE 7409777L SE 7409777 A SE7409777 A SE 7409777A SE 7409777 A SE7409777 A SE 7409777A SE 7409777 L SE7409777 L SE 7409777L
Authority
SE
Sweden
Prior art keywords
substrate
protein
layer
antigen
purification
Prior art date
Application number
SE7409777A
Other versions
SE464784B (en
Inventor
I Giaever
Original Assignee
Gen Electric
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Electric filed Critical Gen Electric
Publication of SE7409777L publication Critical patent/SE7409777L/xx
Publication of SE464784B publication Critical patent/SE464784B/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated

Abstract

Method and apparatus for the detection and purification of proteins and antibodies based upon the effect that any arbitrary protein will adsorb onto a substrate in a monomolecular layer only, but that a specific antibody (or antigen) for such arbitrary protein will bond thereto to from a bi-molecular protein layer on the substrate is disclosed. In practicing this invention, a first layer of protein is adsorbed onto a substrate and the coated substrate is then exposed to a solution suspected of containing the specific antibody(or antigen) of interest. The substrate is then examined to determine whether a monomolecular or bimolecular layer of protein is adhering thereon. Optical, electrical, And chemical means for examining the coated substrate are disclosed. Purification is provided by severing the immunological bond with weak acid.
SE7409777A 1973-07-30 1974-07-29 SET FOR THE DETECTION OF PROTEINS AND MEDICINAL HAZARDS SE464784B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38411373A 1973-07-30 1973-07-30

Publications (2)

Publication Number Publication Date
SE7409777L true SE7409777L (en) 1975-01-31
SE464784B SE464784B (en) 1991-06-10

Family

ID=23516091

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7409777A SE464784B (en) 1973-07-30 1974-07-29 SET FOR THE DETECTION OF PROTEINS AND MEDICINAL HAZARDS

Country Status (7)

Country Link
JP (2) JPS5944583B2 (en)
BR (1) BR7406086D0 (en)
CA (1) CA1047918A (en)
DE (2) DE2433246C2 (en)
IT (1) IT1212274B (en)
NL (1) NL177939C (en)
SE (1) SE464784B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5238789A (en) * 1975-08-14 1977-03-25 Sinai School Medicine Method of identifying hematocyte type and adaptability
DE2638250C2 (en) * 1975-08-27 1985-11-28 General Electric Co., Schenectady, N.Y. Diagnostic method for determining the presence or absence of a specific protein in a biological sample, as well as device for carrying out the method
DE2638251A1 (en) * 1975-08-27 1977-06-08 Gen Electric Antibody purification - by dipping antigen-coated substrate into antibody solution then dipping into immunological complex splitting reagent
ATE30780T1 (en) * 1981-06-22 1987-11-15 Battelle Memorial Institute PROCEDURE FOR DETERMINING BIOACTIVE SUBSTANCES.
DE3215484A1 (en) * 1982-04-26 1983-11-03 Sagax Instrument AB, 18302 Täby MULTIPLE LAYERS OF LAYER AND PROCESS FOR DETECTING AND / OR MEASURING THE CONCENTRATION OF A CHEMICAL SUBSTANCE, IN PARTICULAR BIOLOGICAL ORIGIN
JPS6432150A (en) * 1987-07-29 1989-02-02 Teijin Ltd Reflection color measuring instrument
JPH073388B2 (en) * 1987-08-10 1995-01-18 帝人株式会社 Film thickness change measuring device
JPH0188778U (en) * 1987-12-02 1989-06-12
DE4436910A1 (en) * 1994-10-15 1996-04-18 Behringwerke Ag Regenerable solid phase for carrying out specific binding reactions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1025772A (en) * 1972-06-26 1978-02-07 Ivar Giaever Method and apparatus for detection and purification of proteins and antibodies

Also Published As

Publication number Publication date
JPS6130215B2 (en) 1986-07-11
DE2433246C2 (en) 1986-04-17
CA1047918A (en) 1979-02-06
BR7406086D0 (en) 1975-05-13
SE464784B (en) 1991-06-10
JPS59160763A (en) 1984-09-11
NL177939B (en) 1985-07-16
IT1212274B (en) 1989-11-22
JPS5076226A (en) 1975-06-21
JPS5944583B2 (en) 1984-10-30
NL177939C (en) 1985-12-16
DE2463435C2 (en) 1986-12-04
NL7410231A (en) 1975-02-03
DE2433246A1 (en) 1975-02-13

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