SE7404515L - - Google Patents
Info
- Publication number
- SE7404515L SE7404515L SE7404515A SE7404515A SE7404515L SE 7404515 L SE7404515 L SE 7404515L SE 7404515 A SE7404515 A SE 7404515A SE 7404515 A SE7404515 A SE 7404515A SE 7404515 L SE7404515 L SE 7404515L
- Authority
- SE
- Sweden
- Prior art keywords
- catechol
- aminoalkyl
- antioxidant
- vinylpyrrolidone
- opthalmic
- Prior art date
Links
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 2
- 230000003078 antioxidant effect Effects 0.000 abstract 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N o-dihydroxy-benzene Natural products OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 abstract 1
- 229930182837 (R)-adrenaline Natural products 0.000 abstract 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- -1 aminoalkyl catechol Chemical compound 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004327 boric acid Substances 0.000 abstract 1
- 229920001577 copolymer Chemical compound 0.000 abstract 1
- 229960005139 epinephrine Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1430565 Opthalmic preparations BARNESHIND PHARMACEUTICAL INC 28 May 1974 [29 May 1973] 23612/74 Heading A5B Stable opthalmic compositions of pH 5.5-8.5 comprise (a) an aqueous medium, (b) 0.1-10 weight % of a C8-12 4-aminoalkyl catechol, (c) 0.1-5% of a vinylpyrrolidone polymer containing at least 70% vinylpyrrolidone residues, (d) 0.1-2.5% of a borate calculated as boric acid and (e) an antioxidant. The aminoalkyl catechol may be of formula; wherein R and R<1> are H or C1-3 alkyl and X is H or OH, e.g. epinephrine. The polymer may be polyvinyl pyrrolidone or copoly(vinyl pyrrolidone/vinyl acetate). The antioxidant may be erythrorbic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36501373A | 1973-05-29 | 1973-05-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7404515L true SE7404515L (en) | 1974-12-02 |
| SE429719B SE429719B (en) | 1983-09-26 |
Family
ID=23437123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7404515A SE429719B (en) | 1973-05-29 | 1974-04-03 | PROCEDURE FOR STABILIZING A WATER SOLUTION OF ADRENALIN |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5727086B2 (en) |
| CA (1) | CA1013255A (en) |
| DE (1) | DE2422760A1 (en) |
| FR (1) | FR2231377B1 (en) |
| GB (1) | GB1430565A (en) |
| NL (1) | NL7407133A (en) |
| SE (1) | SE429719B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6271269U (en) * | 1985-10-25 | 1987-05-07 | ||
| JPH0723302B1 (en) * | 1989-08-03 | 1995-03-15 | ||
| FR2679138B1 (en) * | 1991-07-17 | 1995-03-03 | Theramex | ANTI-GLAUCOMA PHARMACEUTICAL COMPOSITIONS AND THEIR PROCESS FOR OBTAINING SAME. |
| FR2740337B1 (en) * | 1995-10-27 | 1997-11-21 | Rhone Poulenc Rorer Sa | STABILIZED PHARMACEUTICAL COMPOSITIONS CONTAINING A DERIVATIVE HAVING ADRENERGIC ACTIVITY |
| FR2740338B1 (en) * | 1995-12-01 | 1997-12-05 | Rhone Poulenc Rorer Sa | STABILIZED PHARMACEUTICAL COMPOSITIONS CONTAINING DOBUTAMINE |
| ES2224651T3 (en) * | 1998-04-02 | 2005-03-01 | Novartis Ag | METHOD FOR STABILIZING PHARMACEUTICAL COMPOSITIONS THROUGH THE SPECIAL USE OF AN ANTIOXIDANT. |
-
1974
- 1974-03-28 FR FR7410718A patent/FR2231377B1/fr not_active Expired
- 1974-04-03 SE SE7404515A patent/SE429719B/en not_active IP Right Cessation
- 1974-05-10 DE DE2422760A patent/DE2422760A1/en not_active Ceased
- 1974-05-16 JP JP5393674A patent/JPS5727086B2/ja not_active Expired
- 1974-05-22 CA CA200,496A patent/CA1013255A/en not_active Expired
- 1974-05-28 GB GB2361274A patent/GB1430565A/en not_active Expired
- 1974-05-28 NL NL7407133A patent/NL7407133A/xx active Search and Examination
Also Published As
| Publication number | Publication date |
|---|---|
| SE429719B (en) | 1983-09-26 |
| JPS5727086B2 (en) | 1982-06-08 |
| DE2422760A1 (en) | 1975-01-09 |
| NL7407133A (en) | 1974-12-03 |
| JPS5031023A (en) | 1975-03-27 |
| GB1430565A (en) | 1976-03-31 |
| FR2231377A1 (en) | 1974-12-27 |
| AU6940674A (en) | 1975-11-27 |
| CA1013255A (en) | 1977-07-05 |
| FR2231377B1 (en) | 1977-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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