SE544998C2 - Peptide conjugates of melphalan for the treatment of cancer - Google Patents
Peptide conjugates of melphalan for the treatment of cancerInfo
- Publication number
- SE544998C2 SE544998C2 SE2150017A SE2150017A SE544998C2 SE 544998 C2 SE544998 C2 SE 544998C2 SE 2150017 A SE2150017 A SE 2150017A SE 2150017 A SE2150017 A SE 2150017A SE 544998 C2 SE544998 C2 SE 544998C2
- Authority
- SE
- Sweden
- Prior art keywords
- methyl
- pentan
- cyclopropyl
- cyclopentyl
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
Claims (8)
1. Förening representerad av formel (l): i vilken: R1 är metyl, propanyl, propan-2-yl, pentan-3-yl, cyklopropylmetyl, 2-metylpropan-1-yl, 2- etylbutan-1-yl, 2-propylpentan-1-yl, (2S)-butan-2-y|, (2R)-butan-2-y|, (2S)-pentan-2-y|, (2R)- pentan-2-yl, (2R)-hexan-2-y|, (2S)-hexan-2-y|, cyklopropyl, cyklobutyl, cyklopentyl eller cyklohexyl; och R2 är Br, Cl, I, CN, metyl, etyl, n-propyl, propan-2-yl, cyklopropyl, 1-metyl-1-cyklopropyl, cyklobutyl, 1-metyl-1-cyklobutyl, cyklopentyl, 1-metyl-1-cyklopentyl, Si(CH3)s, C(CHs)s eller CXFz, CX2F eller CXa, där X är Cl eller Br, såväl som farmaceutiskt godtagbara salter och/eller solvat därav.
2. Förening enligt patentkrav 1, i vilken: R1 är propan-2-yl, pentan-3-yl, 2-metylpropan-1-yl, 2-etylbutan-1-yl, 2-propylpentan-1-yl, (2S)-butan-2-y|, (2R)-butan-2-y|, (2S)-pentan-2-y|, (2R)-pentan-2-yl, cyklopropyl eller cyklopentyl; och R2 är Br, Cl, I, CN, metyl, etyl, n-propyl, propan-2-yl, cyklopropyl, 1-metyl-1-cyklopropyl, cyklobutyl, 1-metyl-1-cyklobutyl, cyklopentyl, 1-metyl-1-cyklopentyl, Si(CH3)s, C(CHs)s eller CXF2, CX2F eller CXs där X är Cl eller Br.
3. Förening enligt patentkrav 2, i vilken: R1 är propan-2-yl, pentan-3-yl, (2S)-pentan-2-yl eller (2R)-pentan-2-yl; och R2 är Br, Cl, CN, 1-metyl-1-cyklopropyl, cyklopropyl, Si(CH3)3, eller C(CH3)
4. Förening enligt patentkrav 3, i vilken: 1(2) R1 är pentan-3-yl eller propan-2-yl; och R2 är Br, Si(CH3)3 eller C(CH3)
5. Farmaceutiskt preparat, vilket innefattar en förening såsom definierad i vilket som helst av patentkraven 1-4 i kombination med en farmaceutiskt godtagbar bärare.
6. Förening enligt vilket som helst av patentkraven 1-4 för användning som medikament.
7. Förening enligt vilket som helst av patentkraven 1-4 för användning vid behandling av cancer.
8. Förening för användning enligt patentkrav 7, vilken inkluderar behandling av tumörsjukdomar valda ur den grupp som består av lungcancer, bröstcancer, äggstockscancer, testikelcancer, multipelt myelom och malignt melanom. 2(2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE2150017A SE544998C2 (en) | 2021-01-13 | 2021-01-13 | Peptide conjugates of melphalan for the treatment of cancer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE2150017A SE544998C2 (en) | 2021-01-13 | 2021-01-13 | Peptide conjugates of melphalan for the treatment of cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
SE2150017A1 SE2150017A1 (en) | 2022-07-14 |
SE544998C2 true SE544998C2 (en) | 2023-02-21 |
Family
ID=82702060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE2150017A SE544998C2 (en) | 2021-01-13 | 2021-01-13 | Peptide conjugates of melphalan for the treatment of cancer |
Country Status (1)
Country | Link |
---|---|
SE (1) | SE544998C2 (sv) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011078782A1 (en) * | 2009-12-22 | 2011-06-30 | Oncopeptides Ab | A composition comprising of melphalan derivatives and gemcitabine or etoposide useful in the treatment of cancer |
WO2017093443A1 (en) * | 2015-12-01 | 2017-06-08 | Oncopeptides Ab | Melflufen dosage regimens for cancer |
-
2021
- 2021-01-13 SE SE2150017A patent/SE544998C2/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011078782A1 (en) * | 2009-12-22 | 2011-06-30 | Oncopeptides Ab | A composition comprising of melphalan derivatives and gemcitabine or etoposide useful in the treatment of cancer |
WO2017093443A1 (en) * | 2015-12-01 | 2017-06-08 | Oncopeptides Ab | Melflufen dosage regimens for cancer |
Non-Patent Citations (1)
Title |
---|
Agadzhanyan, Ts. et al, Amino acids and peptides. XIII. Synthesis of asaphan analogs, Armyanskii Khimicheskii Zhurnal (1977), 30(9), 776-80 * |
Also Published As
Publication number | Publication date |
---|---|
SE2150017A1 (en) | 2022-07-14 |
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