SE523761C2 - Oil solution for local application in small volume on the skin of cattle or sheep for elimination of parasites and use thereof - Google Patents

Abstract

A solution for direct application on the skin to eliminate cattle and sheep parasites, particularly Boophilus microplus, including 0.05-25 %, preferably 0.05-10 % and particularly 0.1-2 % w/v relative to the total solution, of a compound of formula (I), in a low-volume formulation designed to release the compound of formula (I) onto the skin and hair for contact activity against parasites.

Description

25 30 525 761 2 Ticks, in particular Boophilus microplus, are very closely associated with grazing land, where they live and are particularly difficult to control.

Today, there is no procedure for truly effective control of ticks, let alone any effective procedure against all the parasites listed above.

WO-A-87/3781, EP-A-295 17 and EP-A-500 209 describe a class of insecticides which are N-phenylpyrazole derivatives. These compounds are given, as they have action against a very large number of parasites, among which Boophilus microplus is included, in also varied areas, such as agriculture, public health and veterinary medicine. What is generally taught in these documents suggests that these insecticidal compounds can be administered in various ways, orally, parenterally, percutaneously and topically. Topical administration includes in particular oral formulations, baits, dietary supplements, solutions for the skin (pour-on), solutions to be atomized (sprays), baths, showers, jets, powders, greases, shampoos, creams, etc. Pour-on-type skin solutions are provided for percutaneous administration. Examples 9 in EP-A-295 117 and 291 in EP-A-500 209 describe a pour-on skin solution with 15% insecticide and 85% dimethylsulfoxide, for percutaneous administration of the insecticide.

EP-A-296 381 also describes pyrazole compounds with insecticidal action in agriculture, public health and veterinary medicine. Boophilus microplus is one of the mentioned very numerous target groups. The forms of administration here are very numerous and include, for example, solutions, emulsions, suspensions, powders, pastes, granules and aerosols.

The problem which is raised is to find a completely effective means adapted to control parasites in cattle and sheep, in particular ticks, in particular Bophililus microplus, in cattle and in particular lice and vomiting in sheep, under conditions for their rearing. animal. 20 25 523 761 The applicant has found that it was possible to control Boophilus microplus effectively 3 for cattle by means of a special topical formulation. He has also found that this formulation was effective against lice in sheep and fl ugas called "vomit fl uga" in sheep.

The present invention thus aims to provide a new composition completely effective against Boophilus microplus and also against all other parasites described above, such as in particular lice and "vomiting" in sheep, which composition is completely adapted to control these parasites under conditions of breeding the - said animals.

Another object of the invention is to provide such a formulation which has a long effective duration, preferably longer than or equal to two months.

Another object of the invention is to provide such a formulation, which is a simple and rapid use, fully compatible with the use on herds comprising a large number of animals.

Another object of the invention is to provide such a formulation which is completely suitable for extensive rearing on pasture and in use intended to protect the animals during the period of regrouping and completion (Feed Lot in the USA), namely a period of final rearing, whereby a large number of animals are regrouped in a fence with reduced area during an average period of two months before slaughter.

The present invention thus relates to a solution for direct application to the skin, intended for the elimination of parasites in cattle and sheep, in particular ticks, especially Boophilus microplus in cattle and lice and vomiting in sheep, which solution comprises 0.05-25 % w / v, based on the total solution, of a compound of formula (I) R 2 R 2, wherein: R 1 is CN or methyl or a halogen atom; R; is S (O) 3, R 3 or 4,5-dicyanoimidazol-2-yl or haloalkyl; R; is alkyl or haloalkyl; R4 represents a hydrogen or halogen atom, or an NR5R6-, S (O) mR7-, C (O) R7-, C (O) O-R7-, alkyl-, haloalkyl- or ORg- or an -N = C (R9) (R10) group; R 5 and R 10 each independently represent a hydrogen atom or an alkyl, haloalkyl, C (O) alkyl, alkoxycarbonyl, S (O), CF 3 group; or R 5 and R 10 may together form a divalent alkylene group, which may be interrupted by one or two divalent heteroatoms, such as oxygen or sulfur; R; represents an alkyl or haloalkyl group; R 9 represents an alkyl, haloalkyl group or a hydrogen atom; R 9 represents an alkyl group or a hydrogen atom; RH) represents a phenyl or heteroaryl group optionally substituted by one or more halogen atoms or groups, such as OH, -O-alkyl, -S-alkyl, cyano or alkyl; RH and RH, independently of one another, represent a hydrogen or halogen atom, or optionally CN or NO 2; RH represents a halogen atom or a haloalkyl, haloalkoxy, S (O) qCF 3 or SF 5 group; m, n, q and r, each independently, represent an integer 0, 1 or 2; X represents a trivalent nitrogen atom or a C-RH group, the other three valences of the carbon atom being part of the aromatic ring; provided that when R 1 is methyl, then R 3 is haloalkyl, R 4 is NH 2, R H is Cl, R H is CF 3, and X is N, and R is; 4,5-dicyanoimidazol-2-yl, R 4 is Cl, RH is Cl, RH is CF 3 and X is = C-Cl; 523 761 5 in a small volume formulation designed to release the compound (I) on the skin and hair for contact with parasites.

Preferably in formula (I) is R, CN or methyl; R 2 is S (O), R 3; R 3 is alkyl or haloalkyl; R 4 represents a hydrogen or halogen atom, or an NR 5 R 6, S (O) m R 7, C (O) R 7, alkyl, haloalkyl or ORS or a -N = C (R 9) (R m) group; R 5 and R 6 each independently represent a hydrogen atom or an alkyl, haloalkyl, C (O) alkyl, S (()), CF 3 group; or R 5 and R 6 may together form a divalent alkylene group, which may be interrupted by one or two divalent heteroatoms, such as oxygen or sulfur; R 7 represents an alkyl or haloalkyl group; R 9 represents an alkyl, haloalkyl group or a hydrogen atom; R 9 represents an alkyl group or a hydrogen atom; R 10 represents a phenyl or heteroaryl group optionally substituted by one or more halogen atoms or groups, such as OH, -O-alkyl, -S-alkyl, cyano or alkyl; R 1 and R 5, independently of one another, represent a hydrogen or halogen atom; does R13 represent a halogen atom or a haloalkyl, haloalkoxy, S (O) qCF3 or SF5 group? denotes m, n, q and r, independently of one another, an integer 0, 1 or 2; X represents a trivalent nitrogen atom or a C-R1z group, the other three valences of the carbon atom being part of the aromatic ring; provided that when R 1 is methyl, then R; haloalkyl, R 4 is NH 2, RH is Cl, R 1; is CF 3, and X is N.

However, low concentrations of 0.05-10% w / v, especially 0.1-2%, are preferred. In an optimal way, one settles between 0.25 and 1.5%, in particular about 1%. 523 7616 By solution for direct application to the skin (in English pour-on) is meant a solution ready for use intended to be applied topically locally to the animal, preferably on the animal's back and at several points or by following the spine, and applied in small volume, preferably 5-20 ml / 100 kg, preferably in the order of 10 ml / 100 kg, with a total volume of 10-150 ml / animal, preferably limited to 50 ml.

The compound acts by simple contact, whereby the parasite is impregnated with the compound upon contact of hair and skin.

Consequently, a product is remarkably provided at the same time fully compatible with the requirements of use in extensive rearing in terms of ease of use in particular and with a range of efficacy and efficiency, as well as a long effective duration, adapted to this type of breeding.

By influencing the concentration of compound (I), in particular of compound A, solutions with remarkable effects are produced, with in particular two months' effectiveness against Boophilus microplus, a result which has never been achieved to date.

The solution according to the invention also allows the total elimination of Boophilus microplus in an infected animal in less than 2 days.

As mentioned above, the solution of the present invention is applied topically, in small volume, to the back of the animal. A dispersion of the compound of formula (I) is then remarkably prepared, which is represented by a distribution thereof on the whole body of the animal. It was also found that the animals remained protected during passage in water or exposure to rain.

The dose of compound of formula (I) preferably comprises 0.1-2 mg / kg (weight of the animal), preferably 0.25-1.5 mg / kg and in particular in the order of 1 mg / kg.

Mention may be made in particular of compounds of formula (I), wherein R 1 is CN. Mention may also be made of compounds in which R 2 is S (O) 3, R 3, preferably with n = 1, wherein R 3 is preferably CF; or alkyl, for example methyl or ethyl, or also n = 0, wherein R 3 is preferably CF 3, as well as those where X = C-R 11, wherein Ru is a halogen atom. Also preferred are compounds where RH is a halogen atom, as well as those where RB is haloalkyl, preferably CF3. Within the scope of the present invention, there may be advantageously mentioned compounds which combine two or more of these properties.

A preferred class of compounds of formula (I) consists of such compounds, wherein R 1 is CN, R 3 is haloalkyl, preferably CF 3, or ethyl, R 4 is NH 2, RU and Ru are each independently a halogen atom, and / or RB is haloalkyl.

The alkyl groups within the definition of the compounds of formulas (I) generally comprise 1-6 carbon atoms. The ring formed by the divalent alkylene group, which constitutes R 5 and R 6, as well as the nitrogen atom, to which R 5 and R 6 are attached, are generally a ring having 5, 6 or 7 links.

An especially preferred compound of formula (I) according to the invention is 1- [2,6-Cl2-4-CF3-phenyl] -3-CN-4- [SO-CF2-S-NH2-pyrazole, hereinafter referred to as compound A This compound A is used in particular in an amount of 0.1-2% by weight, in particular in the order of 1%, based on the total solution.

Mention may also be made of the two compounds which differ from the foregoing by the following properties: 1 - n = 0, R 3 = CF; 2-n = 1, R3 = ethyl.

The preparation of compounds of formula (I) may be carried out according to either of the procedures described in WO-A-87/3781, 93/6089, 94/21606 or EP-AO 295 117, or any other procedure which may be carried out by a person skilled in the art. in the field of chemical synthesis. For chemical production of the products according to the invention, it is assumed that those skilled in the art have at their disposal, among other things, the entire contents of “Chemical Abstracts” and the documents, which are cited there. Within the scope of the present invention, the entrapment in solution according to the present invention is not provided by other insecticides.

The solutions according to the invention, which are advantageously oily, generally comprise a diluent or a vehicle and also a solvent (organic solvent) of the compound of formula (I), so that it is not soluble in the diluent.

As the organic solvent useful in the invention, there may be mentioned in particular: acetyl tributyl citrate, fatty acid esters such as dimethyl ester, diisobutyl adipate, acetone, acetonitrile, benzyl alcohol, butyldiglycol, dimethylacetamide, dimethylformamide, n-butyl ether of dipropylene monopolyethylene, ethanol glycol ethanol, , monomethylacetamide, monomethyl ether of dipropylene glycol, ande surface polyoxyethylene glycols, propylene glycol, 2-pyrrolidone, in particular N-methylpyrrolidone, monoethyl ether of diethylene glycol, ethylene glycol, diethyl phthalate or a mixture of at least two thereof.

As vehicle or diluent may be mentioned in particular: vegetable oils, such as soybean, peanut, castor, corn, cotton, olive, grape seed, sunflower oil, etc., mineral oils, such as technical white oil, paraffin, silicone, etc., aliphatic or cyclic hydrocarbons, or also, for example, triglycerides with moderately long chains (in particular Cg-Clz).

Mention may also be made preferably of an emollient and / or spreading agent and / or imaging agent, in particular selected from: - polyvinylpyrrolidone, polyvinyl alcohols, copolymers of vinyl acetate and vinylpyrrolidone, polyethylene glycols, benzyl alcohol, mannitol, glycol, glycerol ethoxylated sorbitan esters, lecithin, sodium carboxymethylcellulose, silicone oils, polydiorganosiloxane oils, in particular polydimethylsiloxane oils (PDMS), for example with silanol functionalities or an oil 45V2, 525 761 9 calcium stearate, triethanolamine stearate, sodium abietate, alkyl sulphates, in particular sodium lauryl sulphate and sodium cetyl sulphate, sodium dodecylbenzenesulphonate, sodium dioctyl sulphosuccinate, fatty acids, in particular such quaternary derivatives of hydrocarbons, 'R' ", Y ', where the groups R are hydrocarbon groups, optionally hydroxyl and Y 'is an anion of a strong acid, such as halide, sulphate and sulfonate anions, cetyltrimethylammonium bromide being part of useful cationic surfactants, - amine salts of the formula N + R'R' 'R' '', where the groups R are hydrocarbon groups, optionally hydroxylated, whereby octadecylamine hydrochloride forms part of useful cationic surfactants, nonionic surfactants, such as sorbitan esters, optionally polyethoxylated, in particular Polysorbate 80, polyethoxylated alkyl ethers, polypropyloxylated fatty alcohols, polyoxypropylene ethyl polyethylene ethyl of castor oil, polyglycerol esters, polyethoxylated fatty alcohols, polyethoxylated fatty acids and copolymers of ethylene oxide and propylene oxide, - amphoteric surfactants, such as substituted lauryl compounds of betaine, or a mixture of at least two thereof.

The solvent is used in proportion to the concentration of compound I and its solubility in this solvent.

Compound A has a solubility of 4.3% rr1 / V in acetyl tributyl citrate. You seek to get the smallest possible volume.

The vehicle is 100% complementary. The emollient is preferably used in an amount of 0.1-10% by volume, in particular 0.25-5% by volume.

The present invention also relates to a process for eliminating parasites in cattle and sheep, in particular Boophilus microplus, by means of a solution for direct application to the skin according to the present invention, so as to obtain a long effective duration and with a broad spectrum, whereby the solution is applied on the back of the animal, preferably by following the spine or at several points.

According to a first embodiment, the method consists in applying the solution to the animals on pasture and / or before they come out on the pasture, the application preferably being renewed every month, preferably every other month.

According to a second embodiment, the method consists in applying the solution to the animals before they come out on the "Feed Lot", whereby this application may be the last before slaughter of the animals.

The procedure can of course also consist of combining these two embodiments, namely the first followed by the second.

In all cases, the efficiency allows each application to be stopped for 1-3 months before slaughter, in particular 1.5-2.5 months, especially about 2 months before slaughter.

The solutions according to the invention can be applied by any means known per se, preferably by means of a spray gun or a dosing bottle.

The purpose of the procedure is non-therapeutic and in particular to clean the skin and hair of the animals in eliminating parasites present there, as well as residues and excrement thereof. This means that the animals are no longer stressed by parasites and their bites, which has positive consequences for, for example, their growth and for the use of the food ration thereof. Another object of the invention is a therapeutic method using the external device according to the invention, intended for the treatment and prevention of parasitic diseases with pathogenic consequences.

The present invention also relates to the use of compounds I, in particular compound A, for the preparation of a solution for direct application to the skin, which solution comprises the compound (I) in a small volume and is designed to release the compound ( I) on the skin and hair by means of a contact action against parasites in cattle and sheep, in particular ticks in cattle, such as Boophilus microplus, and vomiting and lice in sheep.

The use according to the invention relates to the preparation of solutions for the skin, as described above.

The present invention is now described in more detail by means of examples taken as non-limiting and showing the effect of the solutions according to the present invention, with reference to the accompanying drawings, in which: Figure 1 is a graph showing the efficiency, against Boophilus microplus, in solutions for the skin according to the invention, add 0.25%, 0.5% and 1%, calculated on a control, this graph, on the abscissa, including the time in days after application of solutions for the skin, and on the ordinate on the left the number of ticks counted on the animals, to which solutions for the skin according to the invention are applied, and on the ordinate on the right, the number of ticks counted on the controls, - figure 2 is a graph showing the tick population of the animals before they received placebo according to Example 2 with, on the abscissa, the time of day and, on the ordinate, the number of ticks, and 523 761 - fi gur 3 compares the effectiveness of a solution for the skin according to the invention with 1% compound A (filled a rings) with a solution for the skin with 1% fl umethrin (empty rings), with, on the abscissa, the time of day and, on the ordinate, the number of ticks.

EXAMPLE 1: preparation of solutions according to the invention.

Ingredient Function Amount ïoíšrfišš Ä ________________ _1111? šššsïšnš _____ 'UFS ____________ _' "f ø lyïíx-in f R f y LSS išÜsïàí al srei" mu pßín fi šlïa fi AS Bëäšluïïé- ____________ _ '* afcššyíršiššfyïcïšà ___________' Ûšsïšåšeäšl _____ -Éïfg ____________ __ "sšfaßíjš __________________" sßšäffiššsïnï-.Éišf "UQ-SI 1661111 ' x = 0.25 g for solution at 0.25% x = 0.5 g for solution at 0.5% x = 1g for solution at 1% Compound A is dissolved in the solvent before mixing with the other ingredients.

EXAMPLE 2: Study of the effectiveness of the solutions for the skin according to the invention set with 0.25, 0.50 resp. 1% of compound A to combat Boophilus microplus.

The study was conducted on 16 young neutered males of the breed Hereford (weights ranging from 114 to 172 kg).

Three skin solutions were prepared according to Example 1: 1. 1% compound A 2. 0.5% compound A 3. 0.25% compound A 523 761 A placebo was prepared which differed from the skin solutions according to the invention by the absence of compound A.

The studies used 1 ml of skin solution or placebo per 10 kg of animal weight.

The dose volume was applied to the spine of the animal, from the head to the base of the tail.

Between day -24 and -1, the animals were attacked artificially on all occasions with 2,500 larvae of Boophilus microplus. The purpose of an attack for 24 days is to ensure that all stages of Boophilus microplus are present in the animal (eggs, larvae and adults).

On day 0, the animals receive one of the solutions for the skin or placebo.

Before applying the solutions for the skin or placebo, count the ticks, which are known on the different animals in the different groups.

The following table lists the elevated values, the weight of the animals and the dose of solution for the skin or placebo, which dose is applied to each of these animals. 14 "" ëíšp_p ______ "ÜJEF HF" Üïlšíaï šášiššzïr- "víšï (i išï __" 15šš 6513- "__" 1_, öö% '' '' '' '_94 _______ "5-88 _______" 1-34 _______ " ii-Ju "43 470 140 14.0 47 300 154 15.4 39 254 160 16.0 0.50% 34 706 145 14.5 99 452 143 14.3 48 375 114 11.4 45 201 153 15.3 0.25% 40 510 148 14.8 92 453 144 14.4 41 432 155 15.5 36 236 171 17.1 Placebo 96 627 150 15.0 44 482 144 14.4 93 315 140 14.0 97 292 172 17.2 For the count, account is taken of female ticks full of blood, which are loosened, the results are given in Figure 1.

A dose-dependent effect is obtained with an efficiency of 100% for the solution for the skin according to the invention with 1% compound A. However, the less concentrated solutions give remarkable results.

One also notices a high speed of action of the solutions according to the invention, whereby the solution with 1% allows total elimination of Boophilus microplus plus in less than 2 days. EXAMPLE 3: Comparison of the effectiveness between a solution for the skin according to the invention supplemented with 1% compound A and a solution for the skin supplemented with 1% flumethrin.

Animals of the same breed as those in Example 1 were used.

On day 0, the groups were treated with: - solution for the skin with 1% compound A - solution for the skin with 1% fl umethrin (excipient ethylhexyl alcohol and mineral oil) - placebo (same excipient as in the solution according to the invention).

Table 2 below indicates, for each group, the weight of the animals, the dose of solution obtained for the skin and the dose of active substance applied. 525 761 Group Animals No. Weight Dose (ml) Dose (mg / kg) -ïšff-cše-nïríg-Ã ____ "7-1-9" "" "" "" 1-4-1 _______ "12íf1 ________" 1 ____ _ _ 709 125 12.5 1 713 150 15.0 1 710 136 13.6 1 703 138 13.8 1 1% fl umetrin 706 145 14.5 1 711 136 13.6 1 715 132 13.2 1 702 142 14.2 1 701 127 12.7 1 Placebo 717 133 13.3 0 707 133 13.3 0 704 134 13.4 0 718 132 13.2 0 708 143 14.3 0 Day 2-32 the animals receive three times in During the week 5000 larvae of Boophilus microplus.

The results are given in Figures 2 and 3, which show the overall effectiveness of the solution for the skin according to the invention.

EXAMPLE 4: Study of efficiency in the meantime. In this example they worked with solutions for the skin according to the invention containing 0.25, 0.5 or 1% compound A. 523 761 “The composition of these solutions is the same as for the previous example.

The cattle were first attacked, so that all stages of Boophilus microplus were presented (infestation with 5000 larvae, 22 days, 15 days and 8 hours before application of the solution to the skin).

After applying the solutions to the skin, the cattle were further attacked with larvae week by week, for 13 weeks, to determine the effectiveness of the three concentrations.

The results reported in Table 3 below: 525 761 18 * vàišíšë fi låššß fi EššF & SSS & ñ§f__ïäâšàßäàšß fi ëššíïå fi šišåšå fi saai '______________________________ "IISS __' '__ Oens *"' __ 'II @ S _ "_ 1916100100 _____________ _§ ___' '' ____ '' ___ 'ISS Internet in ___'" __ñif __ "_" '_ fl iF__ "_____________ _3' ____-_____" _____ ÉEÜï ____ "__ fl if______" fi if "__ _____________ 'ZF ___'__” __'__ "__" ÉECí "___" _ fi if __ "_'_ ___" R' ' -_'______ Éß} ï ____ “" Éñ§ï '______ fl íf_ "_____________ _5 _____"' "'___-" ___ ɧ1Y _____ "33} ï _"' ___ 3 ©} ï ___ _____________ _üí _________ "'" __ "_ É __ __ _____________ _íf "_" "_" __ "_____ 'ïš} ï" _____ ÉBCí ___ "_'? ñÉí ___ _____________ _ïí _" "'" "_'_'_" ___' ï fi _______ Ü fi Ûí ______ §§Éï _'_ ' __ "" 'ïñQí _ "" "2BÉf ___ It is thus established that the attainment of a remarkable efficiency can achieve or ö exceed two months.

Claims (5)

15 20 25 30 525 761: fsæf: ¶ë. @ =. -. . ,. lq Claims 1 Oil solution for local application in small volume on the skin of bovine or ovine animals for the elimination of parasites, including ticks, in particular Boophilus microplus on bovine animals, and lice and vomiting on sheep, which solution comprises 0.1-2% w / v, based on the total solution, of 1- [2,6-Cl2-4-CF3-phenyl] - 3. -CN-4- [SO-CF3] -5-NH2-pyrazole in a small volume formulation designed to release 1- [2,6-Cl2-4-CF3-phenyl] -3-CN-4- [SO-CF3] -5-NH2-pyrazole1 on skin and hair for contact with parasites. Solution according to Claim 1, characterized in that it comprises 0.25-1.5% w / v, based on the total solution, of 1- [2,6-Cl2-4-CF3-phenyl] -3-CN-4 - [SO-CF 2 -S-NH 2 -pyrazole. Solution according to Claim 1, characterized in that it comprises 1% w / v, based on the total solution, of 1- [2,6-Cl2-4-CF3-phenyl] -3-CN-4- [SO-CE] - S-NH 2 -pyrazole. Solution according to one of Claims 1 to 3, characterized in that it is designed to be applicable in a volume of 5-20 ml, preferably of the order of 10 ml, per 100 kg of animal, with a total volume of 10-150 ml per animal. , preferably limited to 50 ml. Solution according to any one of claims 1-4, characterized in that it comprises a solvent for 1- [2,6-Cl2-4-CF3-phenyl] -3-CN-4- [SO-CF3] -S-NH2-pyrazole and a diluent, optionally a emollient. Solution according to Claim 5, characterized in that the solvent is selected from the group consisting of: acetyl tributyl citrate, fatty acid esters, such as the dimethyl ester, 10 = 25 525 761; "=": = '0 .o .n s. n .... Ü I fl aal: ~ -... I, 2 '---....' '° nu n' '' 20. .... .. _. diisobutyl adipate, acetone, acetonitrile, benzyl alcohol, butyldiglycol, dimethylacetamide, dimethylformamide, n-butyl ether of dipropylene glycol, ethanol, isopropanol, methanol, ethylene glycol monoethyl ether, ethylene glycol monomethylene, monomethylacetylethyloethylene polyethylene polyethylene methylpyrrolidone, monoethyl ether of diethylene glycol, ethylene glycol, diethyl phthalate or a mixture of at least two thereof. Solution according to Claim 5 or 6, characterized in that the diluent is selected from the group consisting of: vegetable oils, such as soybean, peanut, castor, corn, cotton, olive, grape seed, sunflower oil, mineral oils, such as technical white oil, paraffin, silicone, aliphatic or cyclic hydrocarbons, or also, for example, triglycerides with moderately long chains (especially Cg-Cn). Solution according to one of Claims 5 to 7, characterized in that the emollient is selected from the group consisting of: polyvinylpyrrolidone, polyvinyl alcohols, copolymers of vinyl acetate and vinylpyrrolidone, polyethylene glycols, benzyl alcohol, mannitol, glycerol, sorbitol sorbitol, sorbitol, sorbitol, sorbitol and sorbetol silicone oils, anionic surfactants such as alkali metal stearates, in particular sodium, potassium or ammonium, calcium stearate, triethanolamine stearate, sodium acetate, alkyl sulphates, in particular sodium lauryl sulphate and sodium cetyl sulphate, sodium dodecylbenzenesulphonate, sodium sulphonate, sodium sulphate ammonium salts of the formula N * R'R "R" 'R "", Y', where the groups R are hydrocarbon groups, optionally hydroxylated, and Y 'is an anion of a strong acid, such as halide, sulphate and sulfonate anions, wherein cetyltrimethylammonium bromide forms part of 15 20 25 30 10. 11. 523 761 2. 1 useful cationic surfactants, - amine salts of the formula N + R 'R "R"', where the groups R are hydrocarbon groups, optionally hydroxylated, octadecylamine hydrochloride being a part of useful cationic surfactants, - nonionic surfactants, such as sorbitan esters, optionally polyethoxylated, in particular Polysorbate 80 (polyethylene oxide sorbitan monooleate), alkyl ethers polyethoxylated, polypropoxylated fatty alcohols such as polyoxypropylene-L5 stearyl ether, polyethylene glycol stearate, polyethoxylated castor oil derivatives, polyglycerol esters, polyethoxylated fatty alcohols, polyethoxylated fatty acids, and copolymers of ethylene oxide and propylene oxide, - amphoteric surfactants, such as substituted laurylföreningar of betaine, or a mixture of at least two thereof. Solution according to one of Claims 5 to 8, characterized in that the solvent is acetyl tributyl citrate, the diluent is soybean oil and the emollient is polyoxypropylene-1S-stearyl ether. Use of a compound of the formula 1- [2,6-Cl2-4-CF3-phenyl] -3-CN-4- [SO-CF2-S-NH2-pyrazole for the preparation of an oil solution for local application in small volume on the skin, which solution contains 0.1-2% w / v, based on the total solution, of 1- [2,6-Cl2-4- CF3-phenyl] -3-CN-4- [SO-CF3] - 5-NHg-pyrazole and is designed to release the compound (I) on the skin and hair for contact with parasites in cattle and sheep, including ticks, in particular Boophilus microplus on cattle and vomiting and lice on sheep. Use according to Claim 10, characterized in that the solution contains 0.25-1.5% w / v, based on the total solution, of 1- [2,6-Cl 2 -4-CF 3 -phenyl] -3-CN-4 - [SO-CF3] -5-NH2-pyrazole. Use according to claim 10, characterized in that the solution contains 1% by weight / volume, calculated on the total solution, of 1-5. [2,6-Cl2-4-CF3-phenyl] -3-CN-4- [SO-CF2-S-NH2-pyrazole. - - ». Use according to any one of claims 10-12, characterized in that the solution for the skin is designed to be able to be applied in a volume of 5-20 ml, preferably of the order of 10 ml, per 100 kg of animal, with a total volume of 10- 150 ml per animal, preferably limited to 50 ml. Use according to any one of claims 10-13, characterized in that the solution is intended to be applied in an amount of 0.1-2 mg / kg, preferably 0.25 -1.5 mg / kg, in particular in the order of 0.1 mg. / kg. Use according to any one of claims 10-14, for the preparation of such a solution for the skin intended to be applied every month, preferably every other month, to the animal, preferably with the cessation of the applications 1-3 months before slaughter. Non-therapeutic procedure for the treatment of bovine and ovine animals for the elimination of parasites, including ticks, in particular Boophilus microplus of bovine and lice and vomiting of ovine animals, by means of an oily solution comprising 0.1-2% w / v, based on the total the solution, of 1- [2,6-Cl2-4- CF3-phenyl] -3-CN-4- [SO-CF3] -5-NHz-pyrazole in a small volume formulation designed to release 1- [2 , 6-Cl2-4-CF3-phenyl] -3-CN-4- [SO-CF3] -5-NH2-pyrazole on the skin and hair for contact with parasites. Non-therapeutic method according to claim 16, characterized in that the solution contains 0.25-1.5% w / v, based on the total solution, of 1- [2,6-Cl2- 4. -CF3-phenyl] -3-CN-4- [SO-CF3] -S-NH2-pyrazole. 525 761 "31 .s": sïï. Non-therapeutic method according to claim 16, characterized in that the solution contains 1% w / v, based on the total solution, of 1- [2.6 -Cl2-4-CF3- phenyl] -3-CN-4- [SO-CF3] - 5. -NH2-pyrazole.