SE450548B - OPAK Toothpaste - Google Patents

Abstract

An opaque dental cream is disclosed comprising an opacifying agent e.g. TiO2 a binary fluorine system e.g. NaF/Na2PO3F and a synthetic silica polishing agent such as aluminosilicates. The creams may also contain dicalcium phosphate and/or pearlescent flakes.

Description

450 548 a synthetic silica containing up to about 1% by weight of this bonded alumina.

Sodium monofluorophosphate is used in an amount to give about 750-1225 ppm fluorine in the toothpaste, which corresponds to about 0.5-1% by weight of sodium monofluorophosphate in the toothpaste. The preferred amount is about 0.76% by weight, which gives about 1000 ppm of fluoride in the toothpaste.

The sodium monofluorophosphate, Na2PO3F, in its commercially available form can vary widely in purity. It can be used in any suitable degree of purity, provided that any contaminants do not adversely affect the desired properties. Usually the purity is desirable at least 80%.

For best results it should be at least 85% and preferably at least 90% by weight of sodium monofluorophosphate, the remainder being mainly impurities or by-products of the preparation such as sodium fluoride and water-soluble sodium phosphate salt. In other words, the sodium monofluorophosphate used should have a total fluoride content exceeding 12%, preferably higher than 1.2.7%, a free sodium fluoride content of not more than 1.5% and preferably not more than 1.2% and a sodium monofluorophosphate content of at least 12% and preferably at least 12.1%, all calculated as fluorine.

Sodium fluoride is added separately to give an additional amount of fluorine of about 50-1000 ppm (for example 50-100 ppm). This corresponds to about 0.01-0.2% sodium fluoride.

The polish is a synthetically precipitated silica containing up to about 1% by weight of alumina bonded thereto.

Such polishes can also be considered as aluminosilicates, especially sodium aluminosilicates. Common examples are given in U.S. Pat. Nos. 3,906,090, 4,015,996, 4,105,757 and 4,122,160. Commercially available examples of these materials are ZEO 49 and ZEO 49 B from Huber and TIXOSIL 53 from Sifrance. The polish is used in amounts of about 15-20% by weight. 450 548 If desired, a minor amount, for example about 0.5-1.0% by weight, of dicalcium phosphate may be present as an additional polish.

The toothpaste of the present invention is opaque or opaque. Since the polishing agent is characterized by having a refractive index close to that of humectants such as glycerol and sorbitol, commonly used in toothpastes, about 0.5-2% of an agent which makes the cream opaque, for example titanium dioxide or equivalent Association.

The toothpaste usually contains about 50-80% by weight of humectants, such as about 20-30% by weight of glycerol and about 30-30% by weight of sorbitol (70% solution). Other agents which make the cream opaque, for example zinc oxide, may be used in orally acceptable amounts which do not adversely react with the other ingredients of the toothpaste. Water may also be present in small amounts such as about 2-7% by weight. If you want to color the toothpaste, the dyes can be dissolved in the water.

The toothpaste also usually contains a gelling agent such as natural or synthetic rubbers and rubber-like materials such as Irish moss, gum tragacanth, sodium carboxymethylcellulose, polyvinylpyrrolidone and starch.

Sodium carboxymethylcellulose is preferred. The gelling agent content is usually at about 0.1-5% by weight and preferably at about 0.1-0.5%. The effect of the gelling agent can be supplemented with about 7-8% of a filler such as fumed silica or a silica airgel. ZEOSYL 200 from J M Huber is a desirable silica filler. ZEOSYL is a brand name.

Any suitable surfactant or detersive material 450 548 may be incorporated into the dentifrice compositions. Such compatible materials are desirable to provide additional detersive, antifoam and antibacterial properties depending on the particular type of surfactant and are selected accordingly. These detergents are usually water-soluble compounds and may be of an anionic, non-ionic or cationic nature. It is generally preferred to use the water-soluble, non-soap or synthetic organic detergents. Suitable detersive materials are known and include, for example, the water-soluble salts of higher fatty acid monoglyceride monosulfate detergent (for example, sodium coconut fatty acid mixed glyceride monosulfate, higher alkyl sulfate (such as sodium lauryl sulfate), alkyl aryl sulfonate and other propylene sodium sulfonate; surfactants include the substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds, such as those having 12 to 16 carbon atoms in the acyl radical. the fatty acid amides of glycine, sarcosine, alanine, 3-aminopropanoic acid and valine having about 12-16 carbon atoms in the acyl group, however, it is preferred to use the N-lauroyl-myristoyl and palmitoyl sarcoside compounds for optimal results.

The amide compounds can be used in the form of the free acid or preferably as its water-soluble salts, such as the salts of alkali metal, ammonium, amine and alkylolamine.

Particular examples are sodium and potassium N-lauroyl, fmyristoyl and palmitoyl sarcosides, ammonium and ethanolamine N-lauroyl sarcoside, N-lauroyl sarcosine and sodium N-lauroyl glycide and alanine. 450 548.

The surfactant is usually used in an amount of about 1-5% by weight, and especially about 1-3% sodium lauryl sulfate is especially preferred.

Any suitable flavoring or sweetening agent may be used in the preparation of a flavoring agent for the compositions of the present invention. Examples of suitable flavoring ingredients include flavoring oils such as green mint oil, peppermint, evergreen; sassafras, cloves, wormwood, eucalyptus, marjoram, cinnamon, lemon and orange as well as methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, sorbitol, sodium cyclamate and sodium saccharin.

Sodium saccharin is preferred. The flavoring agent is usually present in an amount of about 0.5-15% by weight, preferably about 1%, and the sweetening agent in an amount of about 0.1-0.2%.

If desired, visible particles of pearlescent flakes, for example titanium dioxide coated mica flakes, can be distributed in the toothpaste, usually in an amount of about 0.1-0.3% by weight. The toothpaste can also be striped.

The toothpaste can be packaged in ordinary tubes, for example lined or unlined aluminum tubes or lead tubes lined with VaX.

The toothpastes should have a pH value suitable for practical use. A pH range of about 5-10 is particularly desirable. The reference to pH refers to the pH determination that is made directly on the toothpaste.

The following working examples illustrate the invention. All parts refer to parts by weight unless otherwise stated. 450 548 6 EXAMPLE 1 The following toothpaste is prepared in a conventional manner Eï-êš Glycerol 25.00 Sorbitol (70%) 42.31 Sodium carboxymethylcellulose 0.18 Sodium saccharin 0.17 Sodium monofluorophosphate 0.82 Sodium fluoride 0.02 Water f 3.0 Titanium dioxide 0, Silica low content (approx. 1%) alumina 17.0 Zeosyl 200 7.0 Dicalcium phosphate dihydrate 1.0 Sodium lauryl sulphate 2.0 Flavor 1.0 EXAMPLE 2 Another toothpaste is prepared, again in a conventional manner, with a composition according to Example 1 except that 0.25 parts of titanium dioxide-coated mica flakes are added and the water content is reduced accordingly.

The following Table I shows the compositions of three different toothpastes prepared according to conventional methods, the toothpaste identified as Example 3 being prepared according to the present invention. It can be seen that the composition of Example 3 shows an increased fluorine content and increased fluorine retention effect during the test period compared to conventional opaque toothpastes exemplified by Comparative Control Samples A and B. 450 548 The fluorine content was determined according to the standard method described by Cropper and Puttnam on p. 533 in volume 21 (1970 by The Journal of the Society of Cosmetic Chemists of Great Britain. 450 548 8 TABLE 1 Comparative Samples of Samples AB Example 3 Glycerol 22,222 20,202 25,0 Sorbitol (70% solution) - - 43 .05 Sodium carboxymethylcellulose 0.9, 0,2 Sodium saccharin, 0,2 0,17 Tetrasodium pyrophosphate, - - Benzoic acid - 0,2 - Titanium dioxide - - 1,07 Sodium monofluorophosphate 0,76 0,76 0,76 Sodium fluoride 0,1 0.1 0.1 Water 25.018 23.138 3.96 Dicalcium phosphate dihydrate 48.0 - ~ Alumina (ALCOA C333) - 52.0 - ZEO 49 - 1- 17.0 SYLOID 244 - f 6.0 Sodium lauryl sulfate, 5, 5 1.76 Flavor, 8, 8 1.0 Aging test: Retention of soluble fluorine: Initially 0.110 0.121 0.132 (calculated as After 1 month 0.103 0.111 -% by weight) "3 months 0.093 0.104 0.140" 6 months 0.081 0.096 0.138 "1 year 0.069 0.090 - "2 years 0.061 0.080 -

Claims (4)

450 548 P a t e n t k r a v Opaque toothpaste, characterized in that it comprises 50 to 80% by weight of humectant, 0.1 to 5% by weight of gelling agent, 0.5 to 2% by weight of titanium dioxide as opacifying agent, a binary fluorine-releasing system, which emits 750 - 1225 ppm fluorine from sodium monofluorophosphate and 50 - 1000 ppm fluorine from sodium fluoride and 15 - 20% by weight of a polishing agent with a refractive index close to the refractive index of the humectant, mainly consisting of a synthetic silica containing up to about 1% by weight of this bonded alumina. Toothpaste according to claim 1, characterized in that the sodium fluoride gives 50 - 100 ppm fluorine. Toothpaste according to one of the preceding claims, characterized in that it contains 0.5 # 1% by weight of dicalcine phosphate. Toothpaste according to one of the preceding claims, characterized in that it contains 0.1 - 0.3% pearlescent flakes.