NL8101990A - DENTAL CREAM. - Google Patents

Abstract

An opaque dental cream is disclosed comprising an opacifying agent e.g. TiO2 a binary fluorine system e.g. NaF/Na2PO3F and a synthetic silica polishing agent such as aluminosilicates. The creams may also contain dicalcium phosphate and/or pearlescent flakes.

Description

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Betr ..: Dental cream.

The invention relates to a dental cream for promoting oral hygiene.

In the past, other emes have been used which contain a single fluorescent agent such as sodium fluoride, tin (II) fluoride or sodium mono-5 fluorophosphate (noting that a small portion of commercially available sodium monofluorophosphate contains sodium fluoride).

Recently, e.g. in British Pat. No. 35,627 to the Beecham group and U.S. Pat. No. k,152,719 to Colgate-Palmolive described 10 tooth blades for promoting oral hygiene. which contain two separately added phosphors, i.e., sodium fluoride and sodium monofluorophosphate. However, dental creams containing two such fluorinated agents and a silicon-containing polishing material including a small amount of combined alumina have not been described.

The object of the invention is to provide a dental cream containing sodium fluoride and sodium monofluorophosphate, which promotes oral hygiene, e.g. by reducing the formation of caries and by machining dental remeralization.

Another object of the invention is to provide a silicon oxide abrasive-containing dental cream with high fluorine stability.

The invention now provides an opaque dental cream, which provides 0.5-2% by weight of an opacifying agent, a binary fluorinating system which provides approximately 750-1225 ppm of fluorine from the sodium monofluorophosphate and approximately 50-1000 ppm of the fluorine. of sodium fluoride, and about 15-20% by weight of a polishing agent, which mainly consists of a synthetic precipitated silica containing up to about 1% by weight of aluminum oxide attached thereto, cravat.

sodium monofluorophosphate is used in an amount giving about 750-1225 ppm of fluorine to the dental cream. This corresponds to about 0.5-1% by weight of sodium monofluorophosphate in the dental cream. The preferred amount is about 0.76%, which gives about 1000 ppm of fluorine to the dental screen.

sodium monofluorophosphate, Ha 2 FO 2 F, as commercially available, can vary considerably in purity. It can be used in any suitable 8101990-2 purity, provided that any impurities do not significantly affect the desired properties. Generally, the purity is preferably at least 80%. For best results, it should be at least 85%, preferably at least 90% by weight, of 5 sodium monofluorophosphate, the remainder consisting essentially of impurities or by-products of the preparation such as sodium fluoride and water-soluble sodium phosphate salt. In other words, it has sodium monofluorophosphate used. a total fluoride content of preferably above $ 12, more preferably above $ 12.7, and a content of IQ of not more than 1.5 $, more preferably not more than 1.2 $ of free sodium fluoride j and a sodium monofluorophosphate content of at least 12 $, preferably at least 12.1 $, all calculated as fluorine.

Hydrogen fluoride is added separately to give an additional fluorine amount of about 50-1000 ppm (e.g., 50-100 ppm). This corresponds to about 0.01-0.2 $ sodium fluoride.

The polishing material is a synthetically precipitated silica, containing up to about 1 wt. Alumina bound therewith. Such polishing materials can also be considered as aluminosilates, in particular sodium aluminosilates. Typical examples are described in U.S. Pat. No. 3,906,090 to

Colgate-Palmolive and in U.S. Pat. Nos. 1 + .015,996, 105,757 and 1 + .122,160 to "T.M." Huber. Commercially available examples of these materials are b0 b9 and ΖΕ0 1 + 9 B from Huber and TIXOSIL 53 from Sifrance. The polishing agent is used in amounts of about 15-20 wt.%.

If desired, a small amount, e.g., about 0.5-1% dicalcium phosphate may be present as an additional polishing agent.

The dental cream according to the invention is opaque. Because the polishing agent is characterized by a refractive index, which is close to those of wetting agents, such as glycerine and sorbitol typically used in dental creams, about 0.5-2% of an opacifying agent, such as titanium dioxide or equivalent used of it. The dental cream typically contains about 50-80 wt% wetting agent, e.g. about 20-30 wt.% glycerin and about 30-60 wt.% sorbitol (70% solution}.

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Other make-up agents, such as zinc oxide, can be used in amounts that are acceptable in the mouth and do not react adversely with other ingredients of the dental cream.

Water can also be used in small amounts, such as about 2-7 wt.%. 5 are present. When it is desired to color the tooth cream, dyes can be dissolved in the water.

The dental cream typically also includes a gelling agent, such as the natural and synthetic gums and gummy materials, e.g.

Irish moss, tragacanth, co-sodium carboxymethyl cellulose, polyvinylpyrr-10-lidon and starch.

Sodium carboxymethyl cellulose is preferred. The gelling agent content is typically about 0.1-5 wt.%, Most preferably about 0.1-0.5 wt.%. The gelling agent effect can be supplemented with about 7-8% of a filler, such as a fumed silica or a silica airgel. A preferred silica filler material is ZEOSYL 200 from 1 M. Huber. Zeosyl is a brand.

Any suitable surfactant or detergent material can be included in the dental treatment compositions. Such compatible materials are desirable to provide additional detergent, foaming and anti-bacterial properties depending on the specific type of surfactant and are selected accordingly. These detergents are usually water-soluble compounds, and can be anionic, nonionic or cationic in structure. It is usually preferred to use the water-soluble non-soap or synthetic organic detergents. Suitable detergents are known and include, e.g. the water-soluble salts of higher fatty acid monoglyceride monosulfate detergents (e.g. sodium coconut fatty acid monoglyceride monosulfate), higher alkyl sulfates (e.g. sodium lauryl sulfate), alkyl aryl sulfonates (e.g. sodium 30 dodecyl benzene sulfonate), higher fatty acid esters of 1,2-dihydroxypropane.

Further surfactants include the substantially saturated higher aliphatic acylamides of lower aliphatic amino carboxylic acid compounds, e.g. those with 12-16 carbon atoms in the acyl-35 group. The amino acid portion is generally derived from the 8101990 ** ψ lower aliphatic saturated monoaminocarboxylic acids with about 2-6 carbon atoms, usually the monocarboxylic acid compounds. Suitable compounds are the fatty acid amides of glycine, sarcosine, alanine, 3-aminopropanoic acid and vain, with about 12-16 carbon atoms in the acyl group. However, for optimal effects, the ΒΓ-larcyl, myristyl sarcoside compounds are preferably used.

The amide compounds can be used in the. form of the free acid or preferably as the in. water soluble salts thereof, e.g. the alkali metal, ammonium, amine and alkylolamine salts. Specific examples thereof are sodium and potassium H-laurcyl, myristyl, and palmitoyl sarcosides, ammonium and ethanolamine N-lauryl sarcoside, ΙΓ-lauroyl sarcosine, and sodium N-lauroyl glycide and alanine.

The surfactant is typically used in a. amount of about 1-5 wt.%, preferably about 1-3 wt. sodium-15-lauryl sulfate.

Any suitable flavor or sweetener can be used in formulating a flavor for the compositions of the invention.

Examples of suitable flavor ingredients include the flavoring oils, e.g. oils of spearmint, peppermint, wintergreen, sassafras, 20 cloves, sali, eucalyptus, marjoram, cinnamon, lime and orange, as well as methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, sorbitol, sodium cyclamate and sodium saccharin.

Hatrium saccharin is preferred. Flavor is typically present in an amount of about 0.5-15%, preferably about 25%, and sweetener in an amount of about 0.1-0.2%.

If desired, visible particles of pearlescent (English "peardescent") flakes, such as titanium-coated mica flakes, may be distributed in the dental cream, typically in an amount of about 0.1-0.3% by weight. Also, the dental cream may be streaked.

The dental cream can be placed in conventional tubes, e.g.

lined or unlined aluminum tubes or wax lined lead tubes.

The dental creams must have a suitable pH for use.

A pH range of about 5 to 10 is particularly preferred.

The pH refers to the pH as determined directly on the toothpaste.

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The invention is further illustrated by examples in which all amounts relate to weight unless otherwise indicated.

Example I

5 The following dental cream was prepared by conventional means: parts of glycerol 25.00 sorbitol (70 #) U2.31 sodium carboxymethyl cellulose 0.18 10 sodium saccharin 0.17 sodium monoflunphosphate 0.82 sodium fluoride 0.02 water 3.0 titanium dioxide 0.5 15 silicon dioxide - little (about 1% alumina) 17.0

Zeosyl 200 7.0 dicalcium phosphate dihydrate 1.0 sodium lauryl sulfate 2.0 20 flavoring 1.0

Example II

Another dental cream was again prepared by conventional means, with the composition of Example 1, except that 0.25 parts of titanium dioxide-coated mica flakes were added and the water content was reduced by the same amount.

Example III

In the table below, compositions of three dental creams are shown, which were prepared by conventional means. A composition as described according to the invention indicated by example III. It can be seen from the table that the composition of Example III exhibited a higher fluorine content and a higher fluorine retention during the test period than the conventional opaque dental creams, of which the comparative compositions A and B are examples.

The fluorine content was determined by the standard method, as described by Cropper and Puttnam on page 533 of volume 21 (1970) of The Journal of the Society of Cosmetic Chemists of Great Britain.

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Table • · · · *

Comparative composition example III

A B

glycerol 22.222 20.202 25.0 sorbitol ($ 70 solution) - - 13.05 sodium carboxymethyl cellulose 0.9 1.1 0.2

sodium accharin 0.2 0.2 0.1T

tetrasodium pyrophosphate 0.5 benzoic acid. - 0.2 titanium dioxide - - 1.0 sodium monofluorophosphate 0.76 0.76 0.76 sodium fluoride 0.1 0.1 0.1 water 25.018 23.138 3.96 dicalcium phosphate dihydrate 18.0 alumina (Alcoa C333) - .52.0

Zeo 19: - - 17.0

Syloid 211 - 6.0 sodium lauryl sulfate 1.5 1.5 1.76 flavoring 0.8 0.8 1.0

Aging Tests: Retention of Soluble Fluorine: Initial 0.110 0.121 0.132 (wt. $) 1 Month 0.103 0.111 3 Months. 0.093 0.10L 0.10 6 months 0.018 0.096 0.138 1 year 0.069 0.090 2 years 0.06L 0.080 81 019 9 0

Claims (5)

An opaque dental cream, comprising 0.5-2% by weight of an opacifying agent, a binary fluorinating system giving about 750-1225 ppm of fluorine from sodium manofluorophosphate, and 50-1000 ppm. fluorine, from sodium fluoride, and 15-20% by weight of a polishing agent consisting essentially of a synthetic silicon oxide containing up to about 1% by weight of alumina bound thereto. Dental cream according to claim 1, characterized in that the opacifying agent is titanium dioxide. Dental cream according to claim 1 or 2, characterized in that the sodium fluoride gives 50-100 ppm of fluorine. U. Dental cream according to one or more of claims 1 to 3, characterized in that it contains about 0.5-1% by weight of calcium phosphate. Dental cream according to one or more of Claims 1 to 3, characterized in that it contains about 0.1-0.3% pearlescent-like flakes. 6. Opaque dental cream, essentially as described in the examples. 8101990