SE445076B - Forfarande vid immunanalys der partikelaggregat pavisas med en resistiv-pulsmetod - Google Patents
Forfarande vid immunanalys der partikelaggregat pavisas med en resistiv-pulsmetodInfo
- Publication number
- SE445076B SE445076B SE7810773A SE7810773A SE445076B SE 445076 B SE445076 B SE 445076B SE 7810773 A SE7810773 A SE 7810773A SE 7810773 A SE7810773 A SE 7810773A SE 445076 B SE445076 B SE 445076B
- Authority
- SE
- Sweden
- Prior art keywords
- particle
- particles
- protein
- predetermined size
- antigen
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims description 71
- 238000000034 method Methods 0.000 title claims description 17
- 238000004458 analytical method Methods 0.000 title description 3
- 239000000725 suspension Substances 0.000 claims description 26
- 239000000427 antigen Substances 0.000 claims description 15
- 102000036639 antigens Human genes 0.000 claims description 15
- 108091007433 antigens Proteins 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 230000002776 aggregation Effects 0.000 claims description 5
- 238000004220 aggregation Methods 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000011148 porous material Substances 0.000 description 14
- 239000004816 latex Substances 0.000 description 6
- 229920000126 latex Polymers 0.000 description 6
- 238000001514 detection method Methods 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 230000008105 immune reaction Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 229920005372 Plexiglas® Polymers 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000004931 aggregating effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- GTKRFUAGOKINCA-UHFFFAOYSA-M chlorosilver;silver Chemical compound [Ag].[Ag]Cl GTKRFUAGOKINCA-UHFFFAOYSA-M 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005370 electroosmosis Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229940027941 immunoglobulin g Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/842,952 US4191739A (en) | 1977-10-17 | 1977-10-17 | Antigen-antibody reaction assay employing particle aggregation and resistive pulse analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7810773L SE7810773L (sv) | 1979-04-18 |
| SE445076B true SE445076B (sv) | 1986-05-26 |
Family
ID=25288666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7810773A SE445076B (sv) | 1977-10-17 | 1978-10-16 | Forfarande vid immunanalys der partikelaggregat pavisas med en resistiv-pulsmetod |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4191739A (nl) |
| JP (1) | JPS5480411A (nl) |
| DE (1) | DE2844879A1 (nl) |
| FR (1) | FR2439402A1 (nl) |
| GB (1) | GB2009410B (nl) |
| NL (1) | NL7810199A (nl) |
| SE (1) | SE445076B (nl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2918342A1 (de) * | 1979-05-07 | 1980-11-20 | Behringwerke Ag | Latex-reagenz |
| NL185309C (nl) * | 1980-07-28 | 1990-03-01 | Akzo Nv | Methode voor het bepalen van antigenen met behulp van twee of meer monoklonale antilichamen alsmede immuunreagens. |
| US4459361A (en) * | 1982-06-04 | 1984-07-10 | Angenics, Inc. | Ligand assay with one or two particulate reagents and filter |
| US4521521A (en) * | 1983-03-11 | 1985-06-04 | E. I. Du Pont De Nemours And Company | Particle reagent size distribution measurements for immunoassay |
| WO1985004426A1 (en) * | 1984-03-26 | 1985-10-10 | International Health Services | A method of determining the clotting time of blood and particulate reagents therefor |
| US4713347A (en) * | 1985-01-14 | 1987-12-15 | Sensor Diagnostics, Inc. | Measurement of ligand/anti-ligand interactions using bulk conductance |
| US6060237A (en) * | 1985-02-26 | 2000-05-09 | Biostar, Inc. | Devices and methods for optical detection of nucleic acid hybridization |
| JPS61225656A (ja) * | 1985-03-29 | 1986-10-07 | Toshiba Corp | 検体検査装置 |
| US4721681A (en) * | 1985-05-14 | 1988-01-26 | Fisher Scientific Company | Immunoassay in centrifugal field with complementary particles of differing specific gravities |
| US5501949A (en) * | 1985-12-10 | 1996-03-26 | Murex Diagnostics Corporation | Particle bound binding component immunoassay |
| US5236826A (en) * | 1985-12-10 | 1993-08-17 | Murex Corporation | Immunoassay for the detection or quantitation of an analyte |
| US4794089A (en) * | 1986-03-25 | 1988-12-27 | Midwest Research Microscopy, Inc. | Method for electronic detection of a binding reaction |
| JPH06265551A (ja) * | 1993-03-11 | 1994-09-22 | Hoechst Japan Ltd | ゼータ電位を用いた免疫学的測定方法及び免疫学的測定用キット |
| US5858648A (en) * | 1996-11-04 | 1999-01-12 | Sienna Biotech, Inc. | Assays using reference microparticles |
| EP1385001A4 (en) * | 2001-03-30 | 2007-07-25 | Mitsubishi Kagaku Iatron Inc | REAGENT AND METHOD FOR THE IMMUNE ANALYSIS OF ELASTASE 1 AND METHOD FOR DETECTING PANCREASCONDUCTIVE DISEASE |
| JP4331073B2 (ja) * | 2004-08-31 | 2009-09-16 | デンカ生研株式会社 | 抗原の測定方法及びそのための試薬 |
| US20070202495A1 (en) * | 2006-02-06 | 2007-08-30 | Michael Mayer | Use of resistive-pulse sensing with submicrometer pores or nanopores for the detection of the assembly of submicrometer or nanometer sized objects |
| GB2477287B (en) * | 2010-01-27 | 2012-02-15 | Izon Science Ltd | Control of particle flow in an aperture |
| JP5944118B2 (ja) * | 2011-07-06 | 2016-07-05 | シャープ株式会社 | 粒子測定装置 |
| US9804116B2 (en) | 2014-12-26 | 2017-10-31 | Kabushiki Kaisha Toshiba | Method and device for detecting sample |
| WO2017033296A1 (ja) * | 2015-08-26 | 2017-03-02 | 株式会社日立製作所 | 免疫学的測定装置及び免疫学的測定方法 |
| CN113508285A (zh) * | 2019-03-12 | 2021-10-15 | 国立大学法人东北大学 | 内毒素检测装置、及内毒素的检测方法 |
| CN111239404B (zh) * | 2019-03-31 | 2020-11-27 | 武汉生之源生物科技股份有限公司 | 一种可以同时检测尿样本和血清样本中的视黄醇结合蛋白的检测试剂盒 |
| CN111398137B (zh) * | 2020-04-02 | 2022-07-05 | 武汉生之源生物科技股份有限公司 | 一种基于电阻微米孔颗粒计数器的检测方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1179435A (en) * | 1966-06-17 | 1970-01-28 | Ortho Pharma Corp | Stable Reagent for the Detection of Rheumatoid Arthritis |
| US3815024A (en) * | 1970-02-20 | 1974-06-04 | Gen Electric | Particle analyzer |
| BE793185A (fr) * | 1971-12-23 | 1973-04-16 | Atomic Energy Commission | Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques |
| US3925018A (en) * | 1973-06-08 | 1975-12-09 | Technicon Instr | Method and apparatus for quantitative analysis utilizing particulate reagent material |
| US3984533A (en) * | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| IT1087285B (it) * | 1976-11-10 | 1985-06-04 | Hoffmann La Roche | Procedimento di determinazione immunologico |
| GB1590525A (en) * | 1976-12-10 | 1981-06-03 | Technicon Instr | Biological analysis |
-
1977
- 1977-10-17 US US05/842,952 patent/US4191739A/en not_active Expired - Lifetime
-
1978
- 1978-09-19 GB GB7837376A patent/GB2009410B/en not_active Expired
- 1978-10-10 NL NL7810199A patent/NL7810199A/nl not_active Application Discontinuation
- 1978-10-14 DE DE19782844879 patent/DE2844879A1/de not_active Withdrawn
- 1978-10-16 SE SE7810773A patent/SE445076B/sv not_active IP Right Cessation
- 1978-10-17 JP JP12696478A patent/JPS5480411A/ja active Pending
- 1978-10-17 FR FR7829482A patent/FR2439402A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| NL7810199A (nl) | 1979-04-19 |
| DE2844879A1 (de) | 1979-04-19 |
| FR2439402A1 (fr) | 1980-05-16 |
| US4191739A (en) | 1980-03-04 |
| SE7810773L (sv) | 1979-04-18 |
| GB2009410B (en) | 1982-09-02 |
| GB2009410A (en) | 1979-06-13 |
| JPS5480411A (en) | 1979-06-27 |
| FR2439402B1 (nl) | 1983-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7810773-7 Effective date: 19920510 Format of ref document f/p: F |