SE443362B - PROCEDURE FOR PREPARING HEXAHYDRO-2,6-METANO-3-BENSAZOCINES - Google Patents

PROCEDURE FOR PREPARING HEXAHYDRO-2,6-METANO-3-BENSAZOCINES

Info

Publication number
SE443362B
SE443362B SE7710049A SE7710049A SE443362B SE 443362 B SE443362 B SE 443362B SE 7710049 A SE7710049 A SE 7710049A SE 7710049 A SE7710049 A SE 7710049A SE 443362 B SE443362 B SE 443362B
Authority
SE
Sweden
Prior art keywords
lower alkyl
phenyl
alkyl
halogen
hydrogen
Prior art date
Application number
SE7710049A
Other languages
Swedish (sv)
Other versions
SE7710049L (en
Inventor
T R Lewis
W F Michne
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/818,713 external-priority patent/US4119628A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Priority claimed from DE19782811849 external-priority patent/DE2811849A1/en
Publication of SE7710049L publication Critical patent/SE7710049L/en
Publication of SE443362B publication Critical patent/SE443362B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A compound of the formula I <IMAGE> for use as an intermediate for preparing a corresponding compound of the formula II <IMAGE> in which formulae R1 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, halogen-lower alkenyl, cycloalkyl, cycloalkyl- lower alkyl, 2- or 3-furylmethyl; or 2- or 3-furylmethyl which is substituted, on the unsubstituted ring carbon atoms, by from 1 to 3 methyl groups, phenyl-lower alkyl or phenyl-lower alkyl which is substituted, in the phenyl ring, by from 1 to 2 members of the group consisting of halogen, lower alkyl, hydroxy, lower alkanoyloxy, lower alkoxy, lower alkylmercapto, trifluoromethyl, amino, lower alkanolamino or a single methylenedioxy group which is bonded to adjacent carbon atoms; R2, R2', R2" and R2"' are in each case hydrogen, or three of them are hydrogen and the fourth is halogen, lower alkyl, hydroxy, lower alkanoyloxy, lower alkoxy, lower alkylmercapto, trifluoromethyl, nitro, amino, lower alkanolamino, lower alkoxycarbonylamino or phenyl, or two such groups which are adjacent are together methylenedioxy; R3 is hydrogen or lower alkyl; R4 is hydrogen, lower alkyl, lower alkoxy-lower alkyl, hydroxy-lower alkyl, lower alkylthio-lower alkyl, lower alkyl-sulphinyl-lower alkyl, phenylthio-lower alkyl, phenyl-sulphinyl-lower alkyl, lower alkenyl or halogen- lower alkyl, or R3 and R4 are together divalent lower alkylene, -(CH2)n-, where n is one of the integers 3 or 4; R5 is lower alkyl, lower alkylthio-lower alkyl, lower alkoxy-lower alkyl, lower alkoxy, cycloalkyl, cycloalkyl- lower alkyl, 2- or 3-furyl, 2- or 3-furyl-(CH2)m, where n is an integer from 2 to 4, or 2- or 3-furyl- or 2- or 3- furyl-(CH2)m which is substituted, on the unsubstituted ring carbon atoms, by from 1 to 3 methyl groups, phenyl, phenyl-(CH2)m, or phenyl or phenyl-(CH2)m which is substituted, in the phenyl ring, by from 1 to 2 members of the group consisting of halogen, lower-alkyl, hydroxy, lower alkenoyloxy, lower alkoxy, lower-alkylmercapto, trifluoromethyl, amino, lower alkanolamino or a single methylenedioxy group which is bonded to adjacent carbon atoms; and Alk is lower alkyl; and also a process for the preparation thereof.
SE7710049A 1976-09-22 1977-09-07 PROCEDURE FOR PREPARING HEXAHYDRO-2,6-METANO-3-BENSAZOCINES SE443362B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72537176A 1976-09-22 1976-09-22
US05/818,713 US4119628A (en) 1976-09-22 1977-07-25 Process for preparing hexahydro-11 (eq)-CH2 CH2 COR5 -2,6-methano-3-benzazocines
DE19782811849 DE2811849A1 (en) 1976-09-22 1978-03-17 2,6-Methano-3-benzazocine derivs. - used as analgesics and narcotic antagonists, prepd. from methano-benzoquinoline derivs.

Publications (2)

Publication Number Publication Date
SE7710049L SE7710049L (en) 1978-03-23
SE443362B true SE443362B (en) 1986-02-24

Family

ID=27187488

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7710049A SE443362B (en) 1976-09-22 1977-09-07 PROCEDURE FOR PREPARING HEXAHYDRO-2,6-METANO-3-BENSAZOCINES
SE8501168A SE463420B (en) 1976-09-22 1985-03-08 Alkyl-3-acyloctahydro-2,5-methanobenzo(g)quinoline-3- carboxylates, for use as intermediates for preparing 11(eg)-(2-acylethyl)hexahydro-2,6-methano-3-benzazocines, and a process for preparing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8501168A SE463420B (en) 1976-09-22 1985-03-08 Alkyl-3-acyloctahydro-2,5-methanobenzo(g)quinoline-3- carboxylates, for use as intermediates for preparing 11(eg)-(2-acylethyl)hexahydro-2,6-methano-3-benzazocines, and a process for preparing them

Country Status (2)

Country Link
DK (1) DK153945C (en)
SE (2) SE443362B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK156000C (en) * 1978-03-14 1989-11-06 Sterling Drug Inc ANALOGY PROCEDURE FOR PREPARING 3,6 (EQ), 11 (AX) -TRIMETHYL-8-HYDROXY-11 (EQ) -ACYLETHYL-1,2,3,4,5,6-HEXAHYDRO-2,6-METHANO-3 -BENZAZOCINES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932422A (en) * 1974-05-20 1976-01-13 Sterling Drug Inc. 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones

Also Published As

Publication number Publication date
SE8501168D0 (en) 1985-03-08
SE8501168L (en) 1985-03-08
DK418577A (en) 1978-03-23
SE463420B (en) 1990-11-19
DK153945B (en) 1988-09-26
SE7710049L (en) 1978-03-23
DK153945C (en) 1989-02-13

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