SE8501168D0 - 2,5-METHANOBENZO (G) QUINOLIN-3-CARBOXYLATES FOR USE AS CHEMICAL INTERMEDIATES - Google Patents
2,5-METHANOBENZO (G) QUINOLIN-3-CARBOXYLATES FOR USE AS CHEMICAL INTERMEDIATESInfo
- Publication number
- SE8501168D0 SE8501168D0 SE8501168A SE8501168A SE8501168D0 SE 8501168 D0 SE8501168 D0 SE 8501168D0 SE 8501168 A SE8501168 A SE 8501168A SE 8501168 A SE8501168 A SE 8501168A SE 8501168 D0 SE8501168 D0 SE 8501168D0
- Authority
- SE
- Sweden
- Prior art keywords
- lower alkyl
- phenyl
- alkyl
- halogen
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Abstract
A compound of the formula I <IMAGE> for use as an intermediate for preparing a corresponding compound of the formula II <IMAGE> in which formulae R1 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, halogen-lower alkenyl, cycloalkyl, cycloalkyl- lower alkyl, 2- or 3-furylmethyl; or 2- or 3-furylmethyl which is substituted, on the unsubstituted ring carbon atoms, by from 1 to 3 methyl groups, phenyl-lower alkyl or phenyl-lower alkyl which is substituted, in the phenyl ring, by from 1 to 2 members of the group consisting of halogen, lower alkyl, hydroxy, lower alkanoyloxy, lower alkoxy, lower alkylmercapto, trifluoromethyl, amino, lower alkanolamino or a single methylenedioxy group which is bonded to adjacent carbon atoms; R2, R2', R2" and R2"' are in each case hydrogen, or three of them are hydrogen and the fourth is halogen, lower alkyl, hydroxy, lower alkanoyloxy, lower alkoxy, lower alkylmercapto, trifluoromethyl, nitro, amino, lower alkanolamino, lower alkoxycarbonylamino or phenyl, or two such groups which are adjacent are together methylenedioxy; R3 is hydrogen or lower alkyl; R4 is hydrogen, lower alkyl, lower alkoxy-lower alkyl, hydroxy-lower alkyl, lower alkylthio-lower alkyl, lower alkyl-sulphinyl-lower alkyl, phenylthio-lower alkyl, phenyl-sulphinyl-lower alkyl, lower alkenyl or halogen- lower alkyl, or R3 and R4 are together divalent lower alkylene, -(CH2)n-, where n is one of the integers 3 or 4; R5 is lower alkyl, lower alkylthio-lower alkyl, lower alkoxy-lower alkyl, lower alkoxy, cycloalkyl, cycloalkyl- lower alkyl, 2- or 3-furyl, 2- or 3-furyl-(CH2)m, where n is an integer from 2 to 4, or 2- or 3-furyl- or 2- or 3- furyl-(CH2)m which is substituted, on the unsubstituted ring carbon atoms, by from 1 to 3 methyl groups, phenyl, phenyl-(CH2)m, or phenyl or phenyl-(CH2)m which is substituted, in the phenyl ring, by from 1 to 2 members of the group consisting of halogen, lower-alkyl, hydroxy, lower alkenoyloxy, lower alkoxy, lower-alkylmercapto, trifluoromethyl, amino, lower alkanolamino or a single methylenedioxy group which is bonded to adjacent carbon atoms; and Alk is lower alkyl; and also a process for the preparation thereof.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72537176A | 1976-09-22 | 1976-09-22 | |
US05/818,713 US4119628A (en) | 1976-09-22 | 1977-07-25 | Process for preparing hexahydro-11 (eq)-CH2 CH2 COR5 -2,6-methano-3-benzazocines |
DE19782811849 DE2811849A1 (en) | 1976-09-22 | 1978-03-17 | 2,6-Methano-3-benzazocine derivs. - used as analgesics and narcotic antagonists, prepd. from methano-benzoquinoline derivs. |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8501168D0 true SE8501168D0 (en) | 1985-03-08 |
SE8501168L SE8501168L (en) | 1985-03-08 |
SE463420B SE463420B (en) | 1990-11-19 |
Family
ID=27187488
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7710049A SE443362B (en) | 1976-09-22 | 1977-09-07 | PROCEDURE FOR PREPARING HEXAHYDRO-2,6-METANO-3-BENSAZOCINES |
SE8501168A SE463420B (en) | 1976-09-22 | 1985-03-08 | Alkyl-3-acyloctahydro-2,5-methanobenzo(g)quinoline-3- carboxylates, for use as intermediates for preparing 11(eg)-(2-acylethyl)hexahydro-2,6-methano-3-benzazocines, and a process for preparing them |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7710049A SE443362B (en) | 1976-09-22 | 1977-09-07 | PROCEDURE FOR PREPARING HEXAHYDRO-2,6-METANO-3-BENSAZOCINES |
Country Status (2)
Country | Link |
---|---|
DK (1) | DK153945C (en) |
SE (2) | SE443362B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK156000C (en) * | 1978-03-14 | 1989-11-06 | Sterling Drug Inc | ANALOGY PROCEDURE FOR PREPARING 3,6 (EQ), 11 (AX) -TRIMETHYL-8-HYDROXY-11 (EQ) -ACYLETHYL-1,2,3,4,5,6-HEXAHYDRO-2,6-METHANO-3 -BENZAZOCINES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932422A (en) * | 1974-05-20 | 1976-01-13 | Sterling Drug Inc. | 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones |
-
1977
- 1977-09-07 SE SE7710049A patent/SE443362B/en not_active IP Right Cessation
- 1977-09-21 DK DK418577A patent/DK153945C/en not_active IP Right Cessation
-
1985
- 1985-03-08 SE SE8501168A patent/SE463420B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK418577A (en) | 1978-03-23 |
SE443362B (en) | 1986-02-24 |
DK153945B (en) | 1988-09-26 |
SE8501168L (en) | 1985-03-08 |
DK153945C (en) | 1989-02-13 |
SE7710049L (en) | 1978-03-23 |
SE463420B (en) | 1990-11-19 |
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