SE417091B - Forfarande att framstella farmakologiskt aktiva derivat av 2-karboxialkyl-4,4dimetyl-pyrrolidin-5-on - Google Patents

Forfarande att framstella farmakologiskt aktiva derivat av 2-karboxialkyl-4,4dimetyl-pyrrolidin-5-on

Info

Publication number
SE417091B
SE417091B SE7611774A SE7611774A SE417091B SE 417091 B SE417091 B SE 417091B SE 7611774 A SE7611774 A SE 7611774A SE 7611774 A SE7611774 A SE 7611774A SE 417091 B SE417091 B SE 417091B
Authority
SE
Sweden
Prior art keywords
carboxialkyl
4dimethyl
pyrrolidin
procedure
pharmacologically active
Prior art date
Application number
SE7611774A
Other languages
English (en)
Swedish (sv)
Other versions
SE7611774L (sv
Inventor
F Cassidy
A W Lake
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB43989/75A external-priority patent/GB1560942A/en
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of SE7611774L publication Critical patent/SE7611774L/xx
Publication of SE417091B publication Critical patent/SE417091B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2732-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • C07D207/382-Pyrrolones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
SE7611774A 1975-10-25 1976-10-22 Forfarande att framstella farmakologiskt aktiva derivat av 2-karboxialkyl-4,4dimetyl-pyrrolidin-5-on SE417091B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB43989/75A GB1560942A (en) 1975-10-25 1975-10-25 10,10,-dimethyl-12-azaprostaglandins
GB2127976 1976-05-22

Publications (2)

Publication Number Publication Date
SE7611774L SE7611774L (sv) 1977-04-26
SE417091B true SE417091B (sv) 1981-02-23

Family

ID=26255242

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7611774A SE417091B (sv) 1975-10-25 1976-10-22 Forfarande att framstella farmakologiskt aktiva derivat av 2-karboxialkyl-4,4dimetyl-pyrrolidin-5-on

Country Status (17)

Country Link
US (1) US4136190A (de)
JP (1) JPS5253856A (de)
AT (1) AT364820B (de)
AU (1) AU506442B2 (de)
CA (1) CA1068716A (de)
DE (1) DE2647968A1 (de)
DK (1) DK479076A (de)
ES (2) ES452648A1 (de)
FI (1) FI762999A (de)
FR (1) FR2328465A1 (de)
HU (1) HU174538B (de)
IE (1) IE44299B1 (de)
IL (1) IL50643A (de)
NL (1) NL7611760A (de)
NO (1) NO763566L (de)
NZ (1) NZ182263A (de)
SE (1) SE417091B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524818A (en) * 1974-11-29 1978-09-13 Beecham Group Ltd 12-azaprostaglandins
NZ182264A (en) * 1975-10-25 1979-01-11 Beecham Group Ltd 2-carboxyalkyl-1-hydroxyalkyl-pyrrolidin-3,5-dione or-piperidin-3,6-dione derivatives prarmaceutical compostions
US4187312A (en) * 1975-10-25 1980-02-05 Beecham Group Limited 3-Hydroxy-4,4-dimethyl-5-pyrrolidone derivatives
IL58384A0 (en) * 1978-10-14 1980-01-31 Beecham Group Ltd 12-aza analogues of prostcyclin their preparation and pharmaceutical composition containing them
DE3212591A1 (de) * 1982-04-03 1983-10-13 Gödecke AG, 1000 Berlin 2-pyrrolin-3-carbonitril-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975399A (en) * 1974-08-06 1976-08-17 E. I. Du Pont De Nemours And Company 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones
US4003911A (en) * 1975-09-26 1977-01-18 E. I. Du Pont De Nemours And Company Selected 3-pyrrolidinones and 2,4-pyrrolidindiones

Also Published As

Publication number Publication date
NO763566L (de) 1977-04-26
IL50643A (en) 1980-02-29
IL50643A0 (en) 1976-12-31
JPS5253856A (en) 1977-04-30
FR2328465B1 (de) 1978-11-17
NZ182263A (en) 1979-01-11
FR2328465A1 (fr) 1977-05-20
SE7611774L (sv) 1977-04-26
AU1868776A (en) 1978-04-20
AU506442B2 (en) 1980-01-03
ATA788676A (de) 1981-04-15
AT364820B (de) 1981-11-25
FI762999A (de) 1977-04-26
DK479076A (da) 1977-04-26
ES462849A1 (es) 1978-06-01
DE2647968A1 (de) 1977-05-05
NL7611760A (nl) 1977-04-27
HU174538B (hu) 1980-02-28
US4136190A (en) 1979-01-23
ES452648A1 (es) 1978-03-16
CA1068716A (en) 1979-12-25
IE44299B1 (en) 1981-10-07
IE44299L (en) 1977-04-25

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