SE415762B - Forfarande for framstellnig av terapeutiskt verksamma hexahysrodibenso(b,d)-pyraner med hydroxi-och/eller alkanoyloxi-substituenter i 1-och 9-stellningarna - Google Patents

Forfarande for framstellnig av terapeutiskt verksamma hexahysrodibenso(b,d)-pyraner med hydroxi-och/eller alkanoyloxi-substituenter i 1-och 9-stellningarna

Info

Publication number
SE415762B
SE415762B SE7413833A SE7413833A SE415762B SE 415762 B SE415762 B SE 415762B SE 7413833 A SE7413833 A SE 7413833A SE 7413833 A SE7413833 A SE 7413833A SE 415762 B SE415762 B SE 415762B
Authority
SE
Sweden
Prior art keywords
substitutors
hexahysrodibenso
pyranes
alkanoyloxy
hydroxy
Prior art date
Application number
SE7413833A
Other languages
English (en)
Swedish (sv)
Other versions
SE7413833L (ja
Inventor
R A Archer
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SE7413833L publication Critical patent/SE7413833L/xx
Publication of SE415762B publication Critical patent/SE415762B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
SE7413833A 1973-11-05 1974-11-04 Forfarande for framstellnig av terapeutiskt verksamma hexahysrodibenso(b,d)-pyraner med hydroxi-och/eller alkanoyloxi-substituenter i 1-och 9-stellningarna SE415762B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/413,010 US3968125A (en) 1973-11-05 1973-11-05 Dihydroxyhexahydrodibenzo[b,d]pyrans

Publications (2)

Publication Number Publication Date
SE7413833L SE7413833L (ja) 1975-05-06
SE415762B true SE415762B (sv) 1980-10-27

Family

ID=23635420

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7413833A SE415762B (sv) 1973-11-05 1974-11-04 Forfarande for framstellnig av terapeutiskt verksamma hexahysrodibenso(b,d)-pyraner med hydroxi-och/eller alkanoyloxi-substituenter i 1-och 9-stellningarna

Country Status (26)

Country Link
US (1) US3968125A (ja)
JP (1) JPS6033835B2 (ja)
AR (1) AR202318A1 (ja)
AT (1) AT336012B (ja)
BE (1) BE821716A (ja)
BG (1) BG26387A3 (ja)
CA (1) CA1023753A (ja)
CH (1) CH605894A5 (ja)
CS (1) CS193507B2 (ja)
DD (1) DD116230A5 (ja)
DE (1) DE2451934C2 (ja)
DK (1) DK136719B (ja)
ES (1) ES431674A1 (ja)
FR (1) FR2249664B1 (ja)
GB (1) GB1487637A (ja)
HU (1) HU169193B (ja)
IE (1) IE40023B1 (ja)
IL (1) IL45644A (ja)
NL (1) NL7414439A (ja)
PH (1) PH11788A (ja)
PL (2) PL93908B1 (ja)
RO (1) RO71766A (ja)
SE (1) SE415762B (ja)
SU (1) SU524517A3 (ja)
YU (1) YU36515B (ja)
ZA (1) ZA745751B (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1522057A (en) * 1975-11-03 1978-08-23 Pfizer 9-hydroxydibenzo(b,d)pyrans and intermediates therefor
US4051152A (en) * 1976-01-07 1977-09-27 Sharps Associates Oxo C-ring benzopyrans
US4087546A (en) * 1976-02-17 1978-05-02 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs
US4087545A (en) * 1976-02-17 1978-05-02 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs
SE7704749L (sv) * 1976-05-17 1977-12-05 Pfizer Kinoliner och forfarande och mellanprodukter for framstellning derav
US4054581A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor
US4133819A (en) * 1977-06-17 1979-01-09 Pfizer Inc. Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
US4209520A (en) * 1977-06-17 1980-06-24 Pfizer Inc. Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
US4243674A (en) * 1978-06-12 1981-01-06 Pfizer Inc. 9-Hydroxydibenzo[b,d]pyrans and intermediates therefore
US4454144A (en) * 1982-06-21 1984-06-12 Pfizer Inc. Substituted dibenzo[b,d]pyran analgesics
JPS6299930U (ja) * 1985-12-12 1987-06-25
US8449908B2 (en) * 2000-12-22 2013-05-28 Alltranz, Llc Transdermal delivery of cannabidiol
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
JPWO2003070277A1 (ja) * 2002-02-19 2005-06-09 塩野義製薬株式会社 抗掻痒剤
PT1889198E (pt) 2005-04-28 2015-03-06 Proteus Digital Health Inc Sistema fármaco-informático
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
JP2010535238A (ja) * 2007-07-30 2010-11-18 オールトランツ インコーポレイティド カンナビジオールのプロドラッグ、カンナビジオールのプロドラッグを含む組成物及びその使用方法
WO2009099670A2 (en) * 2008-02-08 2009-08-13 Nektar Therapeutics Al, Corporation Oligomer-cannabinoid conjugates
US20090247619A1 (en) * 2008-03-06 2009-10-01 University Of Kentucky Cannabinoid-Containing Compositions and Methods for Their Use
WO2010095940A2 (en) 2009-02-20 2010-08-26 To-Bbb Holding B.V. Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2019016814A1 (en) 2017-07-20 2019-01-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. PHARMACEUTICAL FILM COMPOSITIONS FOR THE ADMINISTRATION OF LIPOPHILIC COMPOUNDS IN AND / OR THROUGH THE SKIN
EP3681474A1 (en) 2017-09-11 2020-07-22 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Compositions and methods for nasal administration of drugs to brain and for systemic effect
CA3116187A1 (en) 2017-11-29 2019-06-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Cannabinoids compositions and methods
CA3116194A1 (en) 2018-11-04 2020-05-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Orally administrable cannabinoids-containing compositions and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636058A (en) * 1966-03-25 1972-01-18 Hoffmann La Roche 7 10 - dihydro - 3 - alkyl - 6h - dibenzo(b d) pyran-6 9(8h)-diones and 5-hydroxy-7-alkyl-4-chromanones
US3507885A (en) * 1966-03-25 1970-04-21 Hoffmann La Roche 3-alkyl-6h-dibenzo(b,d)pyrans
CH558792A (de) * 1971-10-14 1975-02-14 Petrzilka Theodor Verfahren zur herstellung von tetrahydrodibenzopyranen.

Also Published As

Publication number Publication date
DE2451934C2 (de) 1983-10-06
AU7321274A (en) 1976-03-18
RO71766A (ro) 1982-12-06
IL45644A0 (en) 1974-11-29
ATA886374A (de) 1976-08-15
FR2249664A1 (ja) 1975-05-30
IE40023B1 (en) 1979-02-28
SE7413833L (ja) 1975-05-06
AR202318A1 (es) 1975-05-30
US3968125A (en) 1976-07-06
PL95748B1 (pl) 1977-11-30
PL93908B1 (ja) 1977-07-30
FR2249664B1 (ja) 1978-03-24
YU36515B (en) 1984-02-29
DE2451934A1 (de) 1975-05-07
DK136719C (ja) 1978-04-24
HU169193B (ja) 1976-10-28
AT336012B (de) 1977-04-12
DD116230A5 (ja) 1975-11-12
BG26387A3 (ja) 1979-03-15
CA1023753A (en) 1978-01-03
IL45644A (en) 1978-03-10
DK136719B (da) 1977-11-14
SU524517A3 (ru) 1976-08-05
DK573274A (ja) 1975-07-07
JPS5071678A (ja) 1975-06-13
BE821716A (fr) 1975-04-30
CH605894A5 (ja) 1978-10-13
CS193507B2 (en) 1979-10-31
NL7414439A (nl) 1975-05-07
YU265874A (en) 1982-02-25
JPS6033835B2 (ja) 1985-08-05
ZA745751B (en) 1976-04-28
GB1487637A (en) 1977-10-05
PH11788A (en) 1978-07-05
ES431674A1 (es) 1976-11-16
IE40023L (en) 1975-05-05

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