SE317382B - - Google Patents
Info
- Publication number
- SE317382B SE317382B SE12185/65A SE1218565A SE317382B SE 317382 B SE317382 B SE 317382B SE 12185/65 A SE12185/65 A SE 12185/65A SE 1218565 A SE1218565 A SE 1218565A SE 317382 B SE317382 B SE 317382B
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- alkyl
- reacting
- compound
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
Abstract
The invention comprises compounds of formula <FORM:1045903/C2/1> in which R represents a straight or branched chain C1- 5 alkylene group, R1 represents a hydrogen atom or a C1- 3 alkyl, C1- 3 hydroxyalkyl, acylated C1- 3 hydroxyalkyl or C1- 5 alkoxyalkyl group, R2 and R3 which are the same or different represent hydrogen atoms or C1- 3 alkyl groups or, when taken together as an ethylene group, and in which the benzene nuclei may be substituted by one or more of halogen atoms and trifluoromethyl, C1- 3 alkyl, C1- 3 alkoxy or C1- 3 alkyltio groups; and physiologically acceptable acid-addition salts thereof. The compounds may be prepared by (a) reacting a reaction mixture containing nitrilium or imonium cations of the formulae <FORM:1045903/C2/2> with an amine of the formula <FORM:1045903/C2/3> or (b) by dehydrating a compound of the formula <FORM:1045903/C2/4> or (c) by intramolecular condensation of a compound of the formula <FORM:1045903/C2/5> in which Y represents an oxygen or sulphur atom, or (d) by reacting a primary amine of the formula <FORM:1045903/C2/6> or the amino group alkyl derivatives thereof, with reactive esters of alcohols having the formula <FORM:1045903/C2/7> or <FORM:1045903/C2/8> In each of the above Formulae II, IV, V and VI the benzene nuclei are unsubstituted or substituted as indicated for the compounds of Formula I. 2,11 - Dichloro - dibenz[b,f][1,4] - oxazepine is prepared by reacting 2-chloro-10,11-dihydro-11 - oxo - dibenz[b,f][1,4]-oxazepine with phosphorus oxychloride. Pharmaceutical compositions having neuroplegic, neuroleptic and analgesic activity, for enteral or parenteral administration, comprise a compound of the invention together with a pharmaceutically acceptable carrier.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1190763A CH450422A (en) | 1963-09-27 | 1963-09-27 | Process for the preparation of 11-basic substituted dibenz (b, f) (1,4) oxazepine |
CH676263A CH436297A (en) | 1964-05-27 | 1964-05-27 | Process for the preparation of 11-basic substituted dibenz (b, f) - (1,4) oxazepine |
Publications (1)
Publication Number | Publication Date |
---|---|
SE317382B true SE317382B (en) | 1969-11-17 |
Family
ID=25700142
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE12185/65A SE317382B (en) | 1963-09-27 | 1964-05-22 | |
SE12187/65A SE300111B (en) | 1963-09-27 | 1965-09-20 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE12187/65A SE300111B (en) | 1963-09-27 | 1965-09-20 |
Country Status (9)
Country | Link |
---|---|
BE (1) | BE648683A (en) |
DE (1) | DE1470426C3 (en) |
DK (4) | DK107482C (en) |
ES (1) | ES300317A1 (en) |
FI (1) | FI42214B (en) |
FR (1) | FR3488M (en) |
GB (1) | GB1045903A (en) |
NO (1) | NO115657B (en) |
SE (2) | SE317382B (en) |
-
1964
- 1964-05-21 GB GB21056/64A patent/GB1045903A/en not_active Expired
- 1964-05-22 SE SE12185/65A patent/SE317382B/xx unknown
- 1964-05-25 DE DE1470426A patent/DE1470426C3/en not_active Expired
- 1964-05-26 FR FR975816A patent/FR3488M/en not_active Expired
- 1964-05-27 ES ES300317A patent/ES300317A1/en not_active Expired
- 1964-05-28 FI FI1159/64A patent/FI42214B/fi active
- 1964-05-28 NO NO153434A patent/NO115657B/no unknown
- 1964-05-29 DK DK145765AA patent/DK107482C/en active
- 1964-05-29 DK DK269464AA patent/DK107552C/en active
- 1964-05-29 DK DK145665AA patent/DK107481C/en active
- 1964-12-01 BE BE648683A patent/BE648683A/xx unknown
-
1965
- 1965-03-22 DK DK145865AA patent/DK118463B/en unknown
- 1965-09-20 SE SE12187/65A patent/SE300111B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NO115657B (en) | 1968-11-11 |
DE1470426C3 (en) | 1979-11-08 |
BE648683A (en) | 1964-12-01 |
DK107481C (en) | 1967-06-05 |
FI42214B (en) | 1970-03-02 |
DK107552C (en) | 1967-06-12 |
ES300317A1 (en) | 1964-11-16 |
SE300111B (en) | 1968-04-08 |
DK107482C (en) | 1967-06-05 |
DE1470426B2 (en) | 1979-03-15 |
FR3488M (en) | 1965-08-16 |
GB1045903A (en) | 1966-10-19 |
DE1470426A1 (en) | 1969-12-18 |
DK118463B (en) | 1970-08-24 |
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