SE315598B - - Google Patents
Info
- Publication number
- SE315598B SE315598B SE14127/65A SE1412765A SE315598B SE 315598 B SE315598 B SE 315598B SE 14127/65 A SE14127/65 A SE 14127/65A SE 1412765 A SE1412765 A SE 1412765A SE 315598 B SE315598 B SE 315598B
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- compounds
- group
- atom
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Compounds of the Formula I wherein each of X and Y represent hydrogen, chlorine or bromine atoms or C1- 3 alkyoxy radicals, Z represents a sulphur or oxygen atom, R1 represents a hydrogen atom or a methyl radical, R2 represents a hydrogen atom or a C1- 4 alkyl radical and R3 represents a hydrogen atom or a C1- 4 alkyl radical or R2 and R3 together with the adjacent nitrogen and, optionally, with the inclusion of oxygen having two separate bonds, an imino, C1- 5 alkylimino, C1- 5 hydroxyalkylimino group or an alkanoyloxy alkylimino group of up to 8 carbon atoms as ring member, represent a saturated heterocyclic radical of 5 to 7 ring members, are prepared by reacting compounds of the Formula II with at least double the molar amount of compounds of the formula HNR2R3 or at least double the molar amount of metal compounds of N-acyl derivatives of C1-4 alkylamines, if necessary hydrolysing the reaction products to split off any acyl radicals which may be bound to the nitrogen atom in the side chain, if desired treating a resulting compound of the Formula I containing an imino group as ring member with a C1- 5 alkylene oxide, a reactive mono-ester of a C1- 5 alkane diol or a reactive-ester of an alkanoyloxyalkanol of up to 8 carbon atoms, if desired acylating a compound of the Formula I having a C1- 5 hydroxyalkylimino group as ring member to form a compound having an alkanoyloxyalkylimino group of up to 8 carbon atoms, and, if desired, converting any resulting free base into an acid addition salt thereof with an inorganic or organic acid. <FORM:1080979/C2/1> <FORM:1080979/C2/2> <FORM:1080979/C2/3> <FORM:1080979/C2/4> and <FORM:1080979/C2/5> Thiepins and oxepins of the Formula II may be prepared by reacting the appropriate dibenzo[b,f]thiepin(or oxepin)-10(11H)ione with a metal-methyl or ethyl derivative to give a hydroxy compound of the Formula V, splitting of water and reacting the resulting alkylidene compound of the Formula VI with bromine. Compounds of the Formula VII are formed as by-products in the preparation of compounds of the Formula VI.ALSO:Therapeutic-compositions with adrenolytic and central depressive properties, for oral or parenteral application comprise compounds of the formula (I) <FORM:1080979/A5-A6/1> wherein each of X and Y represents a hydrogen, chlorine or bromine atom or a C1-3 alkyl radical, Z represents a sulphur or oxygen atom, R1 represents a hydrogen atom or methyl radical, each of R2 and R3 represents a hydrogen atom or a C1-4 alkyl radical or R2 and R3, together with the adjacent nitrogen atom and, optionally, with the inclusion of oxygen having two separate bonds, an imino, C1-5 alkylamino or C1-5 hydroxyalkylimino group or an alkenoyloxy alkylimino group of up to 8 carbon atoms, represent a saturated heterocyclic radical of 5-7 ring members, or their salts with organic or inorganic acids, together with a carrier and optionally with other antidepressives.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1421164A CH440318A (en) | 1964-11-03 | 1964-11-03 | Process for the preparation of new thiepin and oxepine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SE315598B true SE315598B (en) | 1969-10-06 |
Family
ID=4398870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE14127/65A SE315598B (en) | 1964-11-03 | 1965-11-02 |
Country Status (13)
Country | Link |
---|---|
AT (1) | AT254879B (en) |
BE (1) | BE671752A (en) |
BR (1) | BR6574511D0 (en) |
CH (1) | CH440318A (en) |
DE (1) | DE1300954B (en) |
DK (1) | DK109565C (en) |
ES (1) | ES319156A1 (en) |
FI (1) | FI43319C (en) |
FR (2) | FR1453003A (en) |
GB (1) | GB1080979A (en) |
IL (1) | IL24558A (en) |
NL (1) | NL6514187A (en) |
SE (1) | SE315598B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2020207A1 (en) * | 1968-10-09 | 1970-07-10 | Leo Ab | CNS-active tri:cyclic amino:ketone(s) |
CH501007A (en) * | 1968-11-27 | 1970-12-31 | Ciba Geigy Ag | Process for the preparation of new thiepin and oxepine derivatives |
DE59607332D1 (en) * | 1995-02-08 | 2001-08-30 | Novartis Ag | Antineurodegenerative 10-aminoaliphatyl-dibenz-b, f oxepine |
WO2003057204A2 (en) * | 2002-01-08 | 2003-07-17 | Nordic Bioscience A/S | Modulation of iamt (pimt or pcmt) in immune system |
-
1964
- 1964-11-03 CH CH1421164A patent/CH440318A/en unknown
-
1965
- 1965-10-26 FI FI652550A patent/FI43319C/en active
- 1965-11-02 DE DEG45082A patent/DE1300954B/en active Pending
- 1965-11-02 AT AT986265A patent/AT254879B/en active
- 1965-11-02 DK DK561565AA patent/DK109565C/en active
- 1965-11-02 NL NL6514187A patent/NL6514187A/xx unknown
- 1965-11-02 SE SE14127/65A patent/SE315598B/xx unknown
- 1965-11-02 GB GB46426/65A patent/GB1080979A/en not_active Expired
- 1965-11-02 ES ES0319156A patent/ES319156A1/en not_active Expired
- 1965-11-03 BE BE671752D patent/BE671752A/xx unknown
- 1965-11-03 IL IL24558A patent/IL24558A/en unknown
- 1965-11-03 BR BR174511/65A patent/BR6574511D0/en unknown
- 1965-11-03 FR FR37079A patent/FR1453003A/en not_active Expired
-
1966
- 1966-02-02 FR FR48142A patent/FR5388M/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FI43319B (en) | 1970-11-30 |
FI43319C (en) | 1971-03-10 |
IL24558A (en) | 1969-09-25 |
FR1453003A (en) | 1966-04-15 |
BR6574511D0 (en) | 1973-08-16 |
DE1300954B (en) | 1969-08-14 |
AT254879B (en) | 1967-06-12 |
GB1080979A (en) | 1967-08-31 |
BE671752A (en) | 1966-05-03 |
DK109565C (en) | 1968-05-13 |
ES319156A1 (en) | 1966-07-01 |
CH440318A (en) | 1967-07-31 |
FR5388M (en) | 1967-09-18 |
NL6514187A (en) | 1966-05-04 |
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