SE0301936D0 - New polypeptide - Google Patents
New polypeptideInfo
- Publication number
- SE0301936D0 SE0301936D0 SE0301936A SE0301936A SE0301936D0 SE 0301936 D0 SE0301936 D0 SE 0301936D0 SE 0301936 A SE0301936 A SE 0301936A SE 0301936 A SE0301936 A SE 0301936A SE 0301936 D0 SE0301936 D0 SE 0301936D0
- Authority
- SE
- Sweden
- Prior art keywords
- polypeptide
- sample
- insulin
- nucleic acid
- sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A polypeptide, which has a binding affinity for insulin such that the KD value of the interaction is at most 1 x 10<-6> M is provided. The polypeptide is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, expression vector comprising the nucleic acid, and host cell comprising the expression vector are additionally provided. Also provided is a method of separation of insulin present in a sample from other constituents in the sample, which method comprises a step of affinity separation, in which step a polypeptide according to the invention is used. Also provided is a method of detection of insulin in a sample, in which method a polypeptide according to the invention is used.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0301936A SE0301936D0 (en) | 2003-06-30 | 2003-06-30 | New polypeptide |
PCT/SE2004/001050 WO2005000883A1 (en) | 2003-06-30 | 2004-06-30 | Polypeptides having binding affinity for insulin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0301936A SE0301936D0 (en) | 2003-06-30 | 2003-06-30 | New polypeptide |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0301936D0 true SE0301936D0 (en) | 2003-06-30 |
Family
ID=27731066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0301936A SE0301936D0 (en) | 2003-06-30 | 2003-06-30 | New polypeptide |
Country Status (2)
Country | Link |
---|---|
SE (1) | SE0301936D0 (en) |
WO (1) | WO2005000883A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0524788D0 (en) | 2005-12-05 | 2006-01-11 | Affibody Ab | Polypeptides |
US8426557B2 (en) | 2007-08-03 | 2013-04-23 | Affibody Ab | IGF-1R binding polypeptides and their use |
GB0805608D0 (en) * | 2008-03-28 | 2008-04-30 | Sec Dep For Environment Food & | Detection method |
US20120165650A1 (en) | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
EP2400990A2 (en) | 2009-02-26 | 2012-01-04 | OSI Pharmaceuticals, LLC | In situ methods for monitoring the emt status of tumor cells in vivo |
WO2014013016A1 (en) | 2012-07-20 | 2014-01-23 | Affibody Ab | Method for determining the her2 status of a malignancy |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE462046C (en) * | 1982-08-23 | 1998-04-27 | Pharmacia Biotech Ab | Hybrid DNA vector containing DNA sequence from Staphylococcus aureus, method for its preparation and bacterium containing the same |
EP0560807A1 (en) * | 1990-11-26 | 1993-09-22 | The Public Health Laboratory Service Board | Immunoglobulin-binding proteins and recombinant dna molecules coding therefor |
US6013763A (en) * | 1996-06-04 | 2000-01-11 | Genentech, Inc. | Peptide variants of protein A |
GB9823071D0 (en) * | 1998-10-21 | 1998-12-16 | Affibody Technology Ab | A method |
SE9901379D0 (en) * | 1999-04-19 | 1999-04-19 | Pharmacia & Upjohn Ab | Receptor structures |
JP4656478B2 (en) * | 2000-02-22 | 2011-03-23 | 株式会社医学生物学研究所 | Antibody library |
AU2001262750A1 (en) * | 2000-06-14 | 2001-12-24 | Medical And Biological Laboratories Co., Ltd. | Method of constructing scfv antibody fused with fluorescent protein |
GB0017720D0 (en) * | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
SE0200943D0 (en) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
-
2003
- 2003-06-30 SE SE0301936A patent/SE0301936D0/en unknown
-
2004
- 2004-06-30 WO PCT/SE2004/001050 patent/WO2005000883A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2005000883A8 (en) | 2005-03-03 |
WO2005000883A1 (en) | 2005-01-06 |
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