SE0203303D0 - Novel Compounds - Google Patents
Novel CompoundsInfo
- Publication number
- SE0203303D0 SE0203303D0 SE0203303A SE0203303A SE0203303D0 SE 0203303 D0 SE0203303 D0 SE 0203303D0 SE 0203303 A SE0203303 A SE 0203303A SE 0203303 A SE0203303 A SE 0203303A SE 0203303 D0 SE0203303 D0 SE 0203303D0
- Authority
- SE
- Sweden
- Prior art keywords
- sub
- novel compounds
- compounds
- enantiomers
- pain
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0203303A SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Novel Compounds |
UAA200503862A UA80988C2 (en) | 2002-11-07 | 2003-05-11 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
TW092130836A TW200418822A (en) | 2002-11-07 | 2003-11-04 | Novel compounds |
CA002502732A CA2502732A1 (en) | 2002-11-07 | 2003-11-05 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
BR0315995-7A BR0315995A (pt) | 2002-11-07 | 2003-11-05 | Composto, uso de um composto composição farmacêutica, métodos para a terapia da dor, de distúrbios gastrointestinais, e da ansiedade em um animal de sangue quente, e, processo para preparar um composto |
US10/533,654 US7253173B2 (en) | 2002-11-07 | 2003-11-05 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain of gastrointestinal disorders |
RU2005111985/04A RU2005111985A (ru) | 2002-11-07 | 2003-11-05 | Производные 4-(фенил-пиперазинил-метил)бензамида и их применение для лечения боли или желудочно-кишечных расстройств |
AU2003278665A AU2003278665B2 (en) | 2002-11-07 | 2003-11-05 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
CNB200380102831XA CN100415729C (zh) | 2002-11-07 | 2003-11-05 | 4-(苯基-哌嗪基-甲基)苯甲酰胺衍生物及其在治疗疼痛或胃肠疾病中的用途 |
PL376894A PL376894A1 (pl) | 2002-11-07 | 2003-11-05 | Pochodne 4-(fenylopiperazynylometylo) benzamidu i ich zastosowanie do leczenia bólu lub zaburzeń żołądkowo-jelitowych |
KR1020057008061A KR20050072482A (ko) | 2002-11-07 | 2003-11-05 | 4(페닐-피페라지닐-메틸)벤즈아미드 유도체 및 통증 또는위장 장애의 치료에 있어서의 그의 용도 |
NZ539484A NZ539484A (en) | 2002-11-07 | 2003-11-05 | 4(phenyl-piperazinyl-methyl)benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
JP2004549776A JP4528128B2 (ja) | 2002-11-07 | 2003-11-05 | 4(フェニル−ピペラジニル−メチル)ベンズアミド誘導体、および疼痛または胃腸障害の治療のためのその使用 |
PCT/SE2003/001707 WO2004041802A1 (en) | 2002-11-07 | 2003-11-05 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
ARP030104053A AR041895A1 (es) | 2002-11-07 | 2003-11-05 | Derivados de 4 (fenil-piperazinil-metil) benzamida y sus usos para el tratamiento del dolor y desordenes gastrointestinales |
EP03770198A EP1562924A1 (en) | 2002-11-07 | 2003-11-05 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
MXPA05004708A MXPA05004708A (es) | 2002-11-07 | 2003-11-05 | Derivados de 4-(fenil-piperacinil-metil)benzamida y su uso para el tratamiento del dolor o trastornos gastrointestinales. |
ZA200503556A ZA200503556B (en) | 2002-11-07 | 2005-05-04 | 4(phenyl-piperazinyl-methyl) benzamide derivatves and their use for the treatment of pain or gastrointestinal disorders |
IS7863A IS7863A (is) | 2002-11-07 | 2005-05-25 | 4 (fenýl-píperasínýl-metýl)bensamíðafleiður og notkun þeirra til að meðhöndla verk eða sjúkdóma í maga og görnum |
NO20052698A NO20052698L (no) | 2002-11-07 | 2005-06-06 | 4(fenylpiperazinyl-metyl)benzamid-derivater og deres anvendelse ved behandling av smerte og gasatrintestinale lidelser. |
US11/774,935 US7960389B2 (en) | 2002-11-07 | 2007-07-09 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0203303A SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Novel Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0203303D0 true SE0203303D0 (sv) | 2002-11-07 |
Family
ID=20289507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0203303A SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Novel Compounds |
Country Status (20)
Country | Link |
---|---|
US (2) | US7253173B2 (xx) |
EP (1) | EP1562924A1 (xx) |
JP (1) | JP4528128B2 (xx) |
KR (1) | KR20050072482A (xx) |
CN (1) | CN100415729C (xx) |
AR (1) | AR041895A1 (xx) |
AU (1) | AU2003278665B2 (xx) |
BR (1) | BR0315995A (xx) |
CA (1) | CA2502732A1 (xx) |
IS (1) | IS7863A (xx) |
MX (1) | MXPA05004708A (xx) |
NO (1) | NO20052698L (xx) |
NZ (1) | NZ539484A (xx) |
PL (1) | PL376894A1 (xx) |
RU (1) | RU2005111985A (xx) |
SE (1) | SE0203303D0 (xx) |
TW (1) | TW200418822A (xx) |
UA (1) | UA80988C2 (xx) |
WO (1) | WO2004041802A1 (xx) |
ZA (1) | ZA200503556B (xx) |
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SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203301D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
CN100549004C (zh) | 2003-10-01 | 2009-10-14 | 阿得罗公司 | 螺环杂环衍生物及其应用方法 |
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SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
DK1781631T3 (da) | 2004-08-02 | 2012-05-14 | Astrazeneca Ab | Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf |
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US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
EA014959B3 (ru) | 2006-06-28 | 2014-10-30 | Амген Инк. | Ингибиторы глицинового переносчика-1 |
KR20110018317A (ko) * | 2008-05-20 | 2011-02-23 | 아스트라제네카 아베 | 불안성 주요 우울 장애의 치료 방법 |
EP3436013A4 (en) | 2016-03-31 | 2019-11-13 | Versi Group, LLC | COMPOSITIONS BASED ON OPIACE RECEPTOR DELTA / OPAACEOUS RECEPTOR DELTA OPTIONAL AGONIST, AND METHODS FOR TREATING PARKINSON'S DISEASE |
CA3073760A1 (en) * | 2017-09-05 | 2019-03-14 | The Royal Institution For The Advancement Of Learning/Mcgill University | Compounds, pharmaceutical compositions and use thereof as inhibitors of ran gtpase |
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-
2002
- 2002-11-07 SE SE0203303A patent/SE0203303D0/xx unknown
-
2003
- 2003-05-11 UA UAA200503862A patent/UA80988C2/uk unknown
- 2003-11-04 TW TW092130836A patent/TW200418822A/zh unknown
- 2003-11-05 BR BR0315995-7A patent/BR0315995A/pt not_active IP Right Cessation
- 2003-11-05 NZ NZ539484A patent/NZ539484A/en unknown
- 2003-11-05 JP JP2004549776A patent/JP4528128B2/ja not_active Expired - Fee Related
- 2003-11-05 RU RU2005111985/04A patent/RU2005111985A/ru not_active Application Discontinuation
- 2003-11-05 EP EP03770198A patent/EP1562924A1/en not_active Withdrawn
- 2003-11-05 WO PCT/SE2003/001707 patent/WO2004041802A1/en active Application Filing
- 2003-11-05 MX MXPA05004708A patent/MXPA05004708A/es active IP Right Grant
- 2003-11-05 US US10/533,654 patent/US7253173B2/en not_active Expired - Fee Related
- 2003-11-05 KR KR1020057008061A patent/KR20050072482A/ko not_active Application Discontinuation
- 2003-11-05 CN CNB200380102831XA patent/CN100415729C/zh not_active Expired - Fee Related
- 2003-11-05 AR ARP030104053A patent/AR041895A1/es unknown
- 2003-11-05 PL PL376894A patent/PL376894A1/pl not_active Application Discontinuation
- 2003-11-05 AU AU2003278665A patent/AU2003278665B2/en not_active Ceased
- 2003-11-05 CA CA002502732A patent/CA2502732A1/en not_active Abandoned
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2005
- 2005-05-04 ZA ZA200503556A patent/ZA200503556B/en unknown
- 2005-05-25 IS IS7863A patent/IS7863A/is unknown
- 2005-06-06 NO NO20052698A patent/NO20052698L/no not_active Application Discontinuation
-
2007
- 2007-07-09 US US11/774,935 patent/US7960389B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4528128B2 (ja) | 2010-08-18 |
PL376894A1 (pl) | 2006-01-09 |
MXPA05004708A (es) | 2005-08-03 |
CN1711252A (zh) | 2005-12-21 |
AU2003278665B2 (en) | 2008-05-22 |
CN100415729C (zh) | 2008-09-03 |
WO2004041802A8 (en) | 2005-03-10 |
EP1562924A1 (en) | 2005-08-17 |
TW200418822A (en) | 2004-10-01 |
BR0315995A (pt) | 2005-09-27 |
JP2006514002A (ja) | 2006-04-27 |
IS7863A (is) | 2005-05-25 |
US20060122193A1 (en) | 2006-06-08 |
RU2005111985A (ru) | 2006-01-20 |
US7253173B2 (en) | 2007-08-07 |
KR20050072482A (ko) | 2005-07-11 |
AR041895A1 (es) | 2005-06-01 |
NZ539484A (en) | 2007-05-31 |
US20070254890A1 (en) | 2007-11-01 |
AU2003278665A1 (en) | 2004-06-07 |
ZA200503556B (en) | 2006-08-30 |
US7960389B2 (en) | 2011-06-14 |
NO20052698D0 (no) | 2005-06-06 |
CA2502732A1 (en) | 2004-05-21 |
UA80988C2 (en) | 2007-11-26 |
WO2004041802A1 (en) | 2004-05-21 |
NO20052698L (no) | 2005-06-06 |
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