SE0104423D0 - Pregnane steroids and their use in the treatment of CNS disorders - Google Patents

Pregnane steroids and their use in the treatment of CNS disorders

Info

Publication number
SE0104423D0
SE0104423D0 SE0104423A SE0104423A SE0104423D0 SE 0104423 D0 SE0104423 D0 SE 0104423D0 SE 0104423 A SE0104423 A SE 0104423A SE 0104423 A SE0104423 A SE 0104423A SE 0104423 D0 SE0104423 D0 SE 0104423D0
Authority
SE
Sweden
Prior art keywords
treatment
cns disorders
steroid
substances
hydroxy
Prior art date
Application number
SE0104423A
Other languages
English (en)
Swedish (sv)
Inventor
Torbjoern Baeckstroem
Per Lundgren
Ming-De Wang
Original Assignee
Umecrine Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Umecrine Ab filed Critical Umecrine Ab
Priority to SE0104423A priority Critical patent/SE0104423D0/xx
Publication of SE0104423D0 publication Critical patent/SE0104423D0/xx
Priority to US10/499,214 priority patent/US7960367B2/en
Priority to JP2003559519A priority patent/JP2005519893A/ja
Priority to PCT/SE2002/002423 priority patent/WO2003059357A1/en
Priority to CNA2009101459536A priority patent/CN101601674A/zh
Priority to DK02793723.4T priority patent/DK1458399T3/da
Priority to CA2468248A priority patent/CA2468248C/en
Priority to AU2002359202A priority patent/AU2002359202C1/en
Priority to ES02793723T priority patent/ES2394639T3/es
Priority to EP10183670.8A priority patent/EP2275109B1/en
Priority to EP02793723A priority patent/EP1458399B1/en
Priority to CNA2009101459540A priority patent/CN101601675A/zh
Priority to CNB028262751A priority patent/CN100518741C/zh
Priority to AU2009201956A priority patent/AU2009201956B2/en
Priority to AU2009201951A priority patent/AU2009201951A1/en
Priority to JP2009256620A priority patent/JP5289281B2/ja
Priority to US12/986,937 priority patent/US8119619B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16Masculine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • A61P25/10Antiepileptics; Anticonvulsants for petit-mal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • A61P25/12Antiepileptics; Anticonvulsants for grand-mal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SE0104423A 2001-12-27 2001-12-27 Pregnane steroids and their use in the treatment of CNS disorders SE0104423D0 (sv)

Priority Applications (17)

Application Number Priority Date Filing Date Title
SE0104423A SE0104423D0 (sv) 2001-12-27 2001-12-27 Pregnane steroids and their use in the treatment of CNS disorders
CNB028262751A CN100518741C (zh) 2001-12-27 2002-12-20 用于治疗中枢神经系统功能紊乱的孕烷类固醇
CA2468248A CA2468248C (en) 2001-12-27 2002-12-20 Pregnane steroids for use in the treatment of cns disorders
ES02793723T ES2394639T3 (es) 2001-12-27 2002-12-20 Esteroides de pregnano para utilización en el tratamiento de trastornos del CNS
PCT/SE2002/002423 WO2003059357A1 (en) 2001-12-27 2002-12-20 Pregnane steroids for use in the treatment of cns disorders
CNA2009101459536A CN101601674A (zh) 2001-12-27 2002-12-20 用于治疗中枢神经系统功能紊乱的孕烷类固醇
DK02793723.4T DK1458399T3 (da) 2001-12-27 2002-12-20 Pregnansteroider til brug i behandlingen af CNS-sygdomme
US10/499,214 US7960367B2 (en) 2001-12-27 2002-12-20 Pregnane steroids and their use in the treatment of CNS disorders
AU2002359202A AU2002359202C1 (en) 2001-12-27 2002-12-20 Pregnane steroids for use in the treatment of CNS disorders
JP2003559519A JP2005519893A (ja) 2001-12-27 2002-12-20 Cns疾患の治療において使用するためのプレグナンステロイド
EP10183670.8A EP2275109B1 (en) 2001-12-27 2002-12-20 Pregnane steroids for use in the treatment of CNS disorders
EP02793723A EP1458399B1 (en) 2001-12-27 2002-12-20 Pregnane steroids for use in the treatment of cns disorders
CNA2009101459540A CN101601675A (zh) 2001-12-27 2002-12-20 用于治疗中枢神经系统功能紊乱的孕烷类固醇
AU2009201951A AU2009201951A1 (en) 2001-12-27 2009-05-18 Pregnane steroids for use in the treatment of CNS disorders
AU2009201956A AU2009201956B2 (en) 2001-12-27 2009-05-18 Pregnane steroids for use in the treatment of CNS disorders
JP2009256620A JP5289281B2 (ja) 2001-12-27 2009-11-10 Cns疾患の治療において使用するためのプレグナンステロイド
US12/986,937 US8119619B2 (en) 2001-12-27 2011-01-07 Pregnane steroids and their use in the treatment of CNS disorders

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0104423A SE0104423D0 (sv) 2001-12-27 2001-12-27 Pregnane steroids and their use in the treatment of CNS disorders

Publications (1)

Publication Number Publication Date
SE0104423D0 true SE0104423D0 (sv) 2001-12-27

Family

ID=20286518

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0104423A SE0104423D0 (sv) 2001-12-27 2001-12-27 Pregnane steroids and their use in the treatment of CNS disorders

Country Status (10)

Country Link
US (2) US7960367B2 (enExample)
EP (2) EP1458399B1 (enExample)
JP (2) JP2005519893A (enExample)
CN (3) CN100518741C (enExample)
AU (3) AU2002359202C1 (enExample)
CA (1) CA2468248C (enExample)
DK (1) DK1458399T3 (enExample)
ES (1) ES2394639T3 (enExample)
SE (1) SE0104423D0 (enExample)
WO (1) WO2003059357A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4914368B2 (ja) * 2004-11-18 2012-04-11 ウメクライン アーベー Gaba−ステロイド拮抗剤およびcns疾患の治療のためのその使用
RU2413516C2 (ru) * 2004-11-18 2011-03-10 Умекрин Аб Гамк-стероидные антагонисты и их применение в лечении нарушений цнс
PL2711371T3 (pl) 2006-11-21 2018-06-29 Asarina Pharma Ab Zastosowanie steroidów pregnanowych i androstanowych do wytwarzania kompozycji farmaceutycznej do leczenia zaburzeń oun
US20090269795A1 (en) * 2007-03-09 2009-10-29 The Research Foundation Of State University Of New York Mutant alpha4betadelta GABAA receptor and methods of treating anxiety or irritability
CN101585862B (zh) * 2008-05-20 2014-12-17 梅克芳股份公司 甾族化合物
WO2011087441A1 (en) 2010-01-14 2011-07-21 Umecrine Mood Ab A pharmaceutical composition comprising 3-beta-hydroxy-5-alpha-pregnan-20-one with improved storage and solubility properties
US10150793B2 (en) * 2011-05-20 2018-12-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonists of CB1 receptor
HRP20170503T1 (hr) 2012-11-28 2017-06-16 Institut National De La Santé Et De La Recherche Médicale (Inserm) 3-(4'-supstituirani)-benzil-eter derivati pregnenolona
ME03351B (me) * 2014-01-29 2019-10-20 Umecrine Cognition Ab Steroidno jedinjenje za upotrebu u lečenju hepatične encefalopatije
JOP20200195A1 (ar) * 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
AR103384A1 (es) 2015-01-12 2017-05-03 Umecrine Cognition Ab 3a-ETINILO, 3b-HIDROXI, 5a-PREGNAN-20-OXIMA COMO MODULADOR DE GABA
US10278977B2 (en) 2016-06-06 2019-05-07 Umecrine Cognition Ab Methods for treating hypersomnolence
RS67063B1 (sr) * 2017-01-09 2025-08-29 Relmada Therapeutics Inc Injektabilne suspenzije
WO2018147791A1 (en) 2017-02-10 2018-08-16 Asarina Pharma Ab 3-beta-hydroxy-5-alpha-pregnan-20-one for use in treatment of essential tremor
AU2018218823B2 (en) 2017-02-10 2022-12-22 Relmada Therapeutics, Inc. 3-beta-hydroxy-5-alpha-pregnan-20-one for use in medical treatment
RU2020130861A (ru) 2018-04-05 2022-05-05 Асарина Фарма Апс Антагонисты гамка для применения в лечении расстройств отмены психоактивного вещества
US11969434B1 (en) 2022-08-29 2024-04-30 Lipocine Inc. Oral allopregnanolone compositions and methods of use
WO2023083980A1 (en) 2021-11-10 2023-05-19 Umecrine Ab Steroid as a modulator of gabaa receptor
WO2023083979A1 (en) * 2021-11-10 2023-05-19 Umecrine Ab 3.beta.-hydroxy, 3.alpha.-ethyl steroids for modulation of the alpha-3 subtype of the gaba-a receptor
US20240383941A1 (en) 2021-11-10 2024-11-21 Umecrine Ab 3-alpha substituted 3-beta-hydroxy-17-oximated androstane compound for modulation of the alpha-3 subtype of the gabaa receptor
US12186327B2 (en) 2022-08-29 2025-01-07 Lipocine Inc. Oral allopregnanolone compositions and methods of use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232917A (en) 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
US5439900A (en) * 1993-02-25 1995-08-08 Bukusoglu; Cuneyt Methods and compositions for providing analgesia and enhanced anesthesia
US5939545A (en) 1994-02-14 1999-08-17 Cocensys, Inc. Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
US5767117A (en) 1994-11-18 1998-06-16 The General Hospital Corporation Method for treating vascular headaches
JP2001527552A (ja) 1997-05-02 2001-12-25 アメリカン・ホーム・プロダクツ・コーポレイション プロゲスチンとして有用な5α−プレグナン−3β,16α−ジオール−20−オンの3−硫酸エステルの医薬上許容される塩およびCNS障害
DK0981349T3 (da) * 1997-05-02 2003-03-10 Wyeth Corp 5-alfa-pregnan-3-beta-ol-20-on-sulfat til behandling af tumorer og CNS sygdomme
CA2289108A1 (en) 1997-05-02 1998-11-12 American Home Products Corporation Salts of 5.alpha.-pregn-16-en-3.beta.-ol-20-one 3-sulphate ester with progestin activity
ATE307592T1 (de) * 1998-03-11 2005-11-15 Torbjoern Backstroem Epiallopregnanolon zur behandlung von krankheiten des cns
WO2000021977A1 (en) 1998-10-13 2000-04-20 American Home Products Corporation Pregnane glucuronides
US20020072509A1 (en) * 2000-10-11 2002-06-13 Stein Donald Gerald Methods for the treatment of a traumatic central nervous system injury

Also Published As

Publication number Publication date
US8119619B2 (en) 2012-02-21
AU2009201956A2 (en) 2010-02-18
JP5289281B2 (ja) 2013-09-11
JP2010065052A (ja) 2010-03-25
CA2468248C (en) 2011-08-16
EP2275109A2 (en) 2011-01-19
CA2468248A1 (en) 2003-07-24
EP2275109A3 (en) 2011-10-12
EP2275109B1 (en) 2013-07-24
CN101601674A (zh) 2009-12-16
ES2394639T3 (es) 2013-02-04
CN1607954A (zh) 2005-04-20
EP1458399A1 (en) 2004-09-22
EP1458399B1 (en) 2012-08-08
WO2003059357A1 (en) 2003-07-24
AU2009201956A1 (en) 2009-06-11
US7960367B2 (en) 2011-06-14
AU2002359202A1 (en) 2003-07-30
AU2002359202B2 (en) 2009-02-19
AU2002359202C1 (en) 2011-03-31
US20110098259A1 (en) 2011-04-28
CN101601675A (zh) 2009-12-16
AU2009201956B2 (en) 2010-11-25
AU2009201951A1 (en) 2009-06-04
DK1458399T3 (da) 2012-11-12
JP2005519893A (ja) 2005-07-07
US20050222099A1 (en) 2005-10-06
CN100518741C (zh) 2009-07-29

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