RU99118680A - NEW AMIDA DERIVATIVES AND THEIR MEDICINAL COMPOSITIONS - Google Patents

Claims (6)

1. Amide derivative of General formula (I) or its salt:

where a means heteroaryl;
X means a bond, O, S, -NR ⁵ -, -NR ⁵ CO-, -NR ⁵ CONH-, -NR ⁵ SO ₂ - or -NR ⁵ C (= NH) NH-;
R ¹ is H, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted cycloalkyl;
R ^2a , R ^2b means H or lower alkyl, which may be the same or different;
R ³ is hydrogen or lower alkyl;
R ^4a , R ^4b means H or OH and may be the same or different, or R ^4a and R ^4b together form = O or = N ~ O-lower alkyl;
R ⁵ means H or lower alkyl. 2. The amide derivative or a salt thereof according to claim 1, wherein A represents thiazolylene, imidazolylene, triazolylene, benzimidazolylene, benzothiazolylene, thiadiazolylene, imidazopyridylene or imidazothiazolylene, and X is a bond, O, S, or -NR ⁵ -. 3. The amide derivative or its salt according to claim 2, wherein A is thiazolylene or imidazolylene, X is —NR ⁵ -; and R ¹ is lower alkyl, which is substituted with an optionally substituted aryl, or an optionally substituted aryl.  4. (S) -2- (2-Benzylamino-4-thiazol-4-yl) -4 '- [2 - [(2-hydroxy-3-phenoxypropyl) amino] ethyl] acetanilide; (S) -2- [2- (3-Fluoroanilino) -4-thiazol-4-yl) -4 '- [2 - [(2-hydroxy-3-phenoxypropyl) amino] ethyl] acetanilide; (S) -2- (2-anilino-4-thiazol-4-yl) -4 '- {2 - [(2-hydroxy-3-phenoxypropyl) amino] propyl} acetanilide; and (S) -2- (2-anilinothiazol-4-yl) -4 '- {2 - [(2-hydroxy-3-phenoxypropyl) amino] ethyl} acetanilide and their salts.  5. A pharmaceutical composition comprising the amide derivative according to claim 1 and a pharmaceutically acceptable carrier thereof.  6. The pharmaceutical composition according to claim 5 as a therapeutic agent for the treatment of diabetes.