RU99113343A - MEDICINAL FORMS OF CYCLOSPORIN FOR ORAL ADMINISTRATION - Google Patents
MEDICINAL FORMS OF CYCLOSPORIN FOR ORAL ADMINISTRATIONInfo
- Publication number
- RU99113343A RU99113343A RU99113343/14A RU99113343A RU99113343A RU 99113343 A RU99113343 A RU 99113343A RU 99113343/14 A RU99113343/14 A RU 99113343/14A RU 99113343 A RU99113343 A RU 99113343A RU 99113343 A RU99113343 A RU 99113343A
- Authority
- RU
- Russia
- Prior art keywords
- dosage form
- form according
- specified
- polyethylene glycol
- oral administration
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims 7
- 108010036949 Cyclosporine Proteins 0.000 title claims 7
- 229960001265 ciclosporin Drugs 0.000 title claims 7
- 239000002552 dosage form Substances 0.000 claims 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 229940119017 Cyclosporine Drugs 0.000 claims 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 4
- -1 polyoxyethylene Polymers 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 229920000151 polyglycol Polymers 0.000 claims 3
- 239000010695 polyglycol Substances 0.000 claims 3
- 125000004432 carbon atoms Chemical group C* 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 239000007902 hard capsule Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920005862 polyol Polymers 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
Claims (16)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/956,841 US5962019A (en) | 1995-08-25 | 1997-10-23 | Oral cyclosporin formulations |
US08/956,841 | 1997-10-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU99113343A true RU99113343A (en) | 2001-04-20 |
RU2174405C2 RU2174405C2 (en) | 2001-10-10 |
Family
ID=25498759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU99113343/14A RU2174405C2 (en) | 1997-10-23 | 1998-10-21 | Cyclosporin composition for oral administration (versions) and method of attainment of immunosuppression in recipient body |
Country Status (20)
Country | Link |
---|---|
US (1) | US5962019A (en) |
EP (1) | EP0956035A1 (en) |
JP (1) | JP2000516267A (en) |
KR (1) | KR20000069688A (en) |
CN (1) | CN1246057A (en) |
AR (1) | AR013710A1 (en) |
AU (1) | AU9810698A (en) |
BR (1) | BR9806271A (en) |
CA (1) | CA2275773A1 (en) |
HU (1) | HUP0004733A3 (en) |
IL (1) | IL130631A0 (en) |
NO (1) | NO993096L (en) |
NZ (1) | NZ336253A (en) |
PL (1) | PL334100A1 (en) |
RU (1) | RU2174405C2 (en) |
SK (1) | SK97199A3 (en) |
TR (1) | TR199901448T1 (en) |
TW (1) | TW592707B (en) |
WO (1) | WO1999020296A1 (en) |
ZA (1) | ZA989684B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5858401A (en) * | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
SK285019B6 (en) | 1997-01-30 | 2006-04-06 | Novartis Ag | Hard gelatine capsule |
IL143604A0 (en) | 1998-12-30 | 2002-04-21 | Dexcel Ltd | Dispersable concentrate for the delivery of cyclosporin |
US6057289A (en) * | 1999-04-30 | 2000-05-02 | Pharmasolutions, Inc. | Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system |
IL148685A0 (en) * | 1999-09-21 | 2002-09-12 | Rtp Pharma Inc | Surface modified particulate compositions of biologically active substances |
PT1438966E (en) | 1999-12-08 | 2007-05-31 | Cyclacel Pharmaceuticals Inc | Use of depsipeptide and congeners thereof as immunosuppressants for treating an infectious disease, an autoimmune disease, allergic reactions or a hyperproliferative skin disease. |
US6828302B1 (en) | 1999-12-08 | 2004-12-07 | Xcyte Therapies, Inc. | Therapeutic uses of depsipeptides and congeners thereof |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US6960563B2 (en) * | 2001-08-31 | 2005-11-01 | Morton Grove Pharmaceuticals, Inc. | Spontaneous emulsions containing cyclosporine |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
MY145753A (en) * | 2001-10-19 | 2012-03-30 | Isotechnika Inc | Novel cyclosporin analog formulations |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
US7282194B2 (en) * | 2004-10-05 | 2007-10-16 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
WO2006110802A1 (en) | 2005-04-12 | 2006-10-19 | Elan Pharma International Limited | Nanoparticulate and controlled release compositions comprising cyclosporine |
US7288520B2 (en) * | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
US7276476B2 (en) * | 2005-07-13 | 2007-10-02 | Allergan, Inc. | Cyclosporin compositions |
US20070015693A1 (en) * | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
US7297679B2 (en) * | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
US7202209B2 (en) | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
US20070015691A1 (en) | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
US7501393B2 (en) | 2005-07-27 | 2009-03-10 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
US7745400B2 (en) * | 2005-10-14 | 2010-06-29 | Gregg Feinerman | Prevention and treatment of ocular side effects with a cyclosporin |
US9839667B2 (en) | 2005-10-14 | 2017-12-12 | Allergan, Inc. | Prevention and treatment of ocular side effects with a cyclosporin |
MX2008011054A (en) * | 2006-03-02 | 2009-03-03 | Alexion Pharma Inc | Prolongation of survival of an allograft by inhibiting complement activity. |
CN101032620B (en) * | 2007-03-08 | 2010-05-19 | 上海凯昭医药科技有限公司 | Cyclosporine emulsion and the preparing method |
CA2681361A1 (en) * | 2007-03-30 | 2008-10-09 | Fovea Pharmaceuticals Sa | Methods for treating neovascular ocular diseases |
AU2008309923B2 (en) * | 2007-10-08 | 2014-04-03 | Fovea Pharmaceuticals | Aqueous ophthalmic formulations |
EP3305312A4 (en) * | 2015-06-05 | 2019-02-27 | Maruho Co., Ltd. | External preparation for transdermal administration |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
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US506219A (en) * | 1893-10-10 | Steam-cooker | ||
US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
DE2819094A1 (en) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING |
FI65914C (en) * | 1978-03-07 | 1984-08-10 | Sandoz Ag | FRAMEWORK FOR PHARMACEUTICAL COMPOSITION OF CYCLOSPORINE A |
GB8305693D0 (en) * | 1983-03-02 | 1983-04-07 | Scherer Ltd R P | Pharmaceutical compositions |
GB8903804D0 (en) * | 1989-02-20 | 1989-04-05 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5118493A (en) * | 1986-05-02 | 1992-06-02 | Brigham And Women's Hospital | Composition having reduced nephrotoxocity comprising a fatty acid containing component and cyclosporine |
HU205861B (en) * | 1986-12-19 | 1992-07-28 | Sandoz Ag | Process for producing hydrosole of pharmaceutically effective material |
US4792449A (en) * | 1987-01-28 | 1988-12-20 | Baxter Travenol Laboratories, Inc. | Method for drug administration |
US5154930A (en) * | 1987-03-05 | 1992-10-13 | The Liposome Company, Inc. | Pharmacological agent-lipid solution preparation |
KR880012221A (en) * | 1987-04-13 | 1988-11-26 | 사노 가즈오 | Pharmaceutical compositions containing esters or amides as active ingredients |
JP2577049B2 (en) * | 1987-06-04 | 1997-01-29 | 三共株式会社 | Cyclosporine preparation |
HU205010B (en) * | 1987-09-15 | 1992-03-30 | Sandoz Ag | Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity |
GB8729153D0 (en) * | 1987-12-14 | 1988-01-27 | Efamol Ltd | Fatty acid compositions |
HU203564B (en) * | 1987-12-21 | 1991-08-28 | Sandoz Ag | Process for producing new orthorombos cyclosporin without solvatation |
ES2033086T3 (en) * | 1988-01-29 | 1993-03-01 | Sankyo Company Limited | A PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION. |
HU201567B (en) * | 1988-07-21 | 1990-11-28 | Gyogyszerkutato Intezet | Process for production of intravenous medical compositions containing cyclosphorin |
US5350741A (en) * | 1988-07-30 | 1994-09-27 | Kanji Takada | Enteric formulations of physiologically active peptides and proteins |
US5342625A (en) * | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
BE1003578A4 (en) * | 1988-10-26 | 1992-04-28 | Sandoz Sa | New ophthalmic compositions of cyclosporine. |
BE1003009A5 (en) * | 1989-02-09 | 1991-10-22 | Sandoz Sa | NOVEL PHARMACEUTICAL COMPOSITIONS BASED ON CYCLOSPORINS. |
US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
US5364632A (en) * | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
EP0544671A4 (en) * | 1990-04-18 | 1993-09-15 | The University Of Utah | Colonic-targeted oral drug-dosage forms based on crosslinked hydrogels containing azobonds and exhibiting ph-dependent swelling |
JPH04253907A (en) * | 1990-05-23 | 1992-09-09 | Green Cross Corp:The | Immunosuppressive agent for intravenous injection |
US5393791A (en) * | 1990-07-19 | 1995-02-28 | Helena Chemical Company | Homogeneous, essentially nonaqueous adjuvant compositions with buffering capability |
HU208491B (en) * | 1990-11-27 | 1993-11-29 | Gyogyszerkutato Intezet | Process for producing oral pharmaceutical composition containing cyclosporin |
US5122383A (en) * | 1991-05-17 | 1992-06-16 | Theratech, Inc. | Sorbitan esters as skin permeation enhancers |
MX9201782A (en) * | 1991-04-19 | 1992-10-01 | Sandoz Ag | PARTICLES OF BIOLOGICALLY ACTIVE SUBSTANCES, SUBSTANTIALLY INSOLUBLE IN WATER, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM. |
IL102236A0 (en) * | 1991-06-27 | 1993-01-14 | Ltt Inst Co Ltd | Topical preparations containing cyclosporin |
JPH0558906A (en) * | 1991-09-06 | 1993-03-09 | Sankyo Co Ltd | Cyclosporin eye-lotion |
GB9208712D0 (en) * | 1992-04-22 | 1992-06-10 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporin derivates |
EP0642332B1 (en) * | 1992-05-13 | 1997-01-15 | Sandoz Ltd. | Ophthalmic compositions containing a cyclosporin |
IT1260505B (en) * | 1992-06-01 | 1996-04-09 | Poli Ind Chimica Spa | ORAL PHARMACEUTICAL SYSTEMS WITH DELAYED DELIVERY FOR THE SPECIFIC RELEASE IN THE COLON |
EP1142568A1 (en) * | 1992-09-25 | 2001-10-10 | Novartis AG | Pharmaceutical compositions containing cyclosporins |
SK283442B6 (en) * | 1993-04-20 | 2003-07-01 | Novartis Ag | Pharmaceutical composition for oral administration |
CN1077800C (en) * | 1993-07-01 | 2002-01-16 | 韩美药品工业株式会社 | Cyclosporin soft capsule composition |
DE4329503A1 (en) * | 1993-09-01 | 1995-03-02 | Galenik Labor Freiburg Gmbh | Pharmaceutical preparations for the targeted treatment of Crohn's disease and ulcerative colitis |
DE4340781C3 (en) * | 1993-11-30 | 2000-01-27 | Novartis Ag | Liquid preparations containing cyclosporin and process for their preparation |
KR0146671B1 (en) * | 1994-02-25 | 1998-08-17 | 김충환 | Cyclosporin-containing powder composition |
RU2158601C2 (en) * | 1994-11-03 | 2000-11-10 | Новартис Аг | Novel medicinal forms of cyclosporine for oral administration having simple formulation and bioavailability, and method of preparation thereof |
HU215966B (en) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Oral multiple emulsion-preconcentrate containing cyclosporin |
KR0167613B1 (en) * | 1994-12-28 | 1999-01-15 | 한스 루돌프 하우스, 니콜 케르커 | Cyclosporin-containing soft capsule compositions |
MX9702809A (en) * | 1995-08-25 | 1998-02-28 | Sangstat Medical Corp | Oral cyclosporin formulations. |
US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
NZ280689A (en) * | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
IL131609A0 (en) * | 1997-03-12 | 2001-01-28 | Abbott Lab | Hydrophilic binary systems for the administration of cyclosporine |
-
1997
- 1997-10-23 US US08/956,841 patent/US5962019A/en not_active Expired - Fee Related
-
1998
- 1998-10-21 TR TR1999/01448T patent/TR199901448T1/en unknown
- 1998-10-21 CN CN98801568A patent/CN1246057A/en active Pending
- 1998-10-21 SK SK97199A patent/SK97199A3/en unknown
- 1998-10-21 EP EP98952393A patent/EP0956035A1/en not_active Withdrawn
- 1998-10-21 TW TW087117445A patent/TW592707B/en active
- 1998-10-21 KR KR1019997005738A patent/KR20000069688A/en active IP Right Grant
- 1998-10-21 JP JP11524568A patent/JP2000516267A/en active Pending
- 1998-10-21 PL PL98334100A patent/PL334100A1/en unknown
- 1998-10-21 CA CA002275773A patent/CA2275773A1/en not_active Abandoned
- 1998-10-21 NZ NZ336253A patent/NZ336253A/en unknown
- 1998-10-21 IL IL13063198A patent/IL130631A0/en unknown
- 1998-10-21 WO PCT/US1998/022330 patent/WO1999020296A1/en not_active Application Discontinuation
- 1998-10-21 BR BR9806271-9A patent/BR9806271A/en not_active IP Right Cessation
- 1998-10-21 RU RU99113343/14A patent/RU2174405C2/en active
- 1998-10-21 AU AU98106/98A patent/AU9810698A/en not_active Abandoned
- 1998-10-21 HU HU0004733A patent/HUP0004733A3/en unknown
- 1998-10-22 AR ARP980105274A patent/AR013710A1/en not_active Application Discontinuation
- 1998-10-23 ZA ZA989684A patent/ZA989684B/en unknown
-
1999
- 1999-06-22 NO NO993096A patent/NO993096L/en not_active Application Discontinuation
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