RU98116668A - GRAPHITE NANOTUBES IN LUMINESCENT ANALYSIS AND METHODS FOR CARRYING OUT THESE ANALYSIS - Google Patents

GRAPHITE NANOTUBES IN LUMINESCENT ANALYSIS AND METHODS FOR CARRYING OUT THESE ANALYSIS

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Publication number
RU98116668A
RU98116668A RU98116668/28A RU98116668A RU98116668A RU 98116668 A RU98116668 A RU 98116668A RU 98116668/28 A RU98116668/28 A RU 98116668/28A RU 98116668 A RU98116668 A RU 98116668A RU 98116668 A RU98116668 A RU 98116668A
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analyte
analysis
substance
interest
luminescence
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RU98116668/28A
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Russian (ru)
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RU2189043C2 (en
Inventor
Ричард Дж. Мэссей
Марк Т. Мартин
Ливен Донг
Минг Лу
Алан Фишер
Фабиан Джеймисон
Пам Лианг
Роберт Хоч
Джонатон К. Лилэнд
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Айджен Интернэшнл, Инк.
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Priority claimed from US08/611,347 external-priority patent/US5866434A/en
Application filed by Айджен Интернэшнл, Инк. filed Critical Айджен Интернэшнл, Инк.
Publication of RU98116668A publication Critical patent/RU98116668A/en
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Claims (18)

1. Нанотрубка, к которой присоединен компонент, соединенный с соединением-меткой, способным к индуцированию люминесценции.1. A nanotube to which a component is attached connected to a tag compound capable of inducing luminescence. 2. Нанотрубка по п. 1, отличающаяся тем, что нанотрубка является графитовой и люминесценция является электрохемилюминесценцией. 2. The nanotube according to claim 1, characterized in that the nanotube is graphite and luminescence is electrochemiluminescence. 3. Графитовая нанотрубка по п. 1, отличающаяся тем, что упомянутый компонент представляет собой ферментный биосенсор. 3. A graphite nanotube according to claim 1, characterized in that said component is an enzymatic biosensor. 4. Композиция для детектирования представляющего интерес аналита, присутствующего в пробе, содержащая графитовую нанотрубку, содержащую функциональную группу, и вещество для проведения анализа, соединенное с упомянутой функциональной группой, причем это вещество для проведения анализа способно связываться с представляющим интерес аналитом. 4. A composition for detecting an analyte of interest present in a sample, containing a graphite nanotube containing a functional group, and an analysis substance coupled to said functional group, the analyte being capable of binding to the analyte of interest. 5. Композиция для детектирования представляющего интерес аналита, присутствующего в пробе, содержащая графитовую нанотрубку, содержащую функциональную группу, и вещество для проведения анализа, соединенное с упомянутой функциональной группой, причем это вещество для проведения анализа связано с представляющим интерес аналитом. 5. A composition for detecting an analyte of interest present in a sample, containing a graphite nanotube containing a functional group, and an analysis substance coupled to said functional group, the substance for analysis being associated with the analyte of interest. 6. Композиция по п. 5, отличающаяся тем, что дополнительно содержит второе вещество для проведения анализа, связанное с аналитом, причем это второе вещество для проведения анализа соединено с соединением-меткой, способным индуцироваться для люминесценции. 6. The composition according to p. 5, characterized in that it further comprises a second substance for analysis associated with the analyte, and this second substance for analysis is connected to a label compound capable of being induced for luminescence. 7. Композиция по п. 4, отличающаяся тем, что упомянутое вещество для проведения анализа содержит по меньшей мере одно вещество, выбранное из группы, включающей добавленный представляющий интерес аналит или добавленный аналог этого аналита, партнер связывания упомянутого аналита или партнер связывания упомянутого аналога, и реакционноспособный компонент, способный связываться с выбранным веществом. 7. The composition according to p. 4, characterized in that said substance for analysis contains at least one substance selected from the group comprising an added analyte of interest or an added analogue of this analyte, a binding partner of said analyte or a binding partner of said analogue, and reactive component capable of binding to the selected substance. 8. Композиция по п. 6, отличающаяся тем, что упомянутое вещество для проведения анализа содержит по меньшей мере одно вещество, выбранное из группы, включающей добавленный представляющий интерес аналит или добавленный аналог этого аналита, партнер связывания упомянутого аналита или партнер связывания упомянутого аналога, и реакционноспособный компонент, способный связываться с выбранным веществом. 8. The composition according to p. 6, characterized in that said substance for analysis contains at least one substance selected from the group comprising an added analyte of interest or an added analogue of this analyte, a binding partner of said analyte or a binding partner of said analogue, and reactive component capable of binding to the selected substance. 9. Способ осуществления анализа связывания для представляющего интерес аналита, присутствующего в пробе, включающий следующие стадии образование композиции, содержащей упомянутую пробу вещество для проведения анализа, соединенное с соединением-меткой, способным индуцироваться для люминесценции, и множество функционализованных графитовых нанотрубок, связанных с веществом для проведения анализа, инкубирование этой композиции с образованием комплекса, который включает графитовую нанотрубку и соединение-метку, сбор этого комплекса в зоне измерения, индуцирование соединения-метки в указанном комплексе для люминесценции, и измерение испускаемой люминесценции для измерения присутствия представляющего интерес аналита в пробе. 9. A method for performing a binding analysis for an analyte of interest present in a sample, comprising the steps of: forming a composition containing said sample, an analyte coupled to a label compound capable of being induced for luminescence, and a plurality of functionalized graphite nanotubes coupled to the substance for analysis, incubation of this composition with the formation of a complex that includes a graphite nanotube and a label compound, collecting this complex in these are measurements, inducing the label compound in said complex for luminescence, and measuring the emitted luminescence to measure the presence of the analyte of interest in the sample. 10. Способ по п. 9, отличающийся тем, что упомянутый комплекс собирают на поверхности средства для индуцирования люминесценции и измерения этой люминесценции. 10. The method according to p. 9, characterized in that the said complex is collected on the surface of the means for inducing luminescence and measuring this luminescence. 11. Способ по п. 10, отличающийся тем, что основан на измерении электрохемилюминесценции, при этом упомянутый комплекс собирают на поверхности электрода. 11. The method according to p. 10, characterized in that it is based on the measurement of electrochemiluminescence, while the said complex is collected on the surface of the electrode. 12. Способ осуществления анализа связывания для представляющего интерес аналита, присутствующего в пробе, основанный на измерении электрохемилюминесценции на поверхности электрода, предусматривающий следующие стадии образование композиции, содержащей указанную пробу вещество для проведения анализа, соединенное с соединением-меткой, способным индуцироваться для электрохемилюминесценции, и множество функционализованных графитовых нанотрубок, связанных с веществом для проведения анализа, инкубирование этой композиции с образованием комплекса, который включает в себя графитовую нанотрубку и соединение-метку, сбор этого комплекса, приведение этого комплекса в контакт с поверхностью электрода и индуцирование соединения-метки в этом комплексе для люминесценции путем подведения напряжения на электрод, и измерение испускаемой люминесценции на поверхности электрода для измерения присутствия представляющего интерес аналита в пробе. 12. A method for performing a binding analysis for an analyte of interest present in a sample based on measuring electrochemiluminescence on the surface of an electrode, the method comprising the steps of: forming a composition containing said sample, an analyte coupled to a label compound capable of being induced for electrochemiluminescence, and functionalized graphite nanotubes associated with the substance for analysis, incubation of this composition with the formation m complex, which includes a graphite nanotube and a tag compound, collecting this complex, bringing this complex into contact with the electrode surface and inducing a tag compound in this complex for luminescence by applying voltage to the electrode, and measuring the emitted luminescence on the electrode surface for measuring the presence of an analyte of interest in a sample. 13. Способ выполнения анализа связывания для представляющего интерес аналита, присутствующего в пробе, основанный на измерении электрохемилюминесценции на поверхности электрода, предусматривающий следующие стадии: образование композиции, содержащей указанную пробу вещество для проведения анализа, соединенное с соединением-меткой, способным индуцироваться для электрохемилюминесценции, и множество магнито-чувствительных, суспендированных, функционализованных графитовых нанотрубок, связанных с веществом для проведения анализа, инкубирование этой композиции с образованием комплекса, который включает в себя функционализованную графитовую нанотрубку и соединение-метку, сбор этого комплекса путем наложения магнитного поля на графитовые нанотрубки, приведение этого комплекса в контакт с поверхностью электрода и индуцирование соединения-метки в этом комплексе для люминесценции путем подведения напряжения на электрод, и измерение испускаемой люминесценции на поверхности электрода для измерения присутствия представляющего интерес аналита в пробе. 13. A method for performing a binding assay for an analyte of interest present in a sample based on measuring electrochemiluminescence on the surface of an electrode, the method comprising the steps of: forming a composition containing said sample substance for analysis coupled to a label compound capable of being induced for electrochemiluminescence, and many magnetically sensitive, suspended, functionalized graphite nanotubes associated with the substance for analysis, inc beating this composition with the formation of a complex that includes a functionalized graphite nanotube and a tag compound, collecting this complex by applying a magnetic field to graphite nanotubes, bringing this complex into contact with the electrode surface, and inducing the tag compound in this complex for luminescence by summing voltage across the electrode; and measuring the emitted luminescence on the surface of the electrode to measure the presence of the analyte of interest in the sample. 14. Способ по п. 13, отличающийся тем, что наложение магнитного поля заставляет комплекс собираться на поверхности электрода. 14. The method according to p. 13, characterized in that the application of a magnetic field causes the complex to assemble on the surface of the electrode. 15. Композиция для использования в качестве реагента в основанном на использовании микрочастиц анализе связывания, содержащая функционализованные графитовые нанотрубки, связанные с веществом для проведения анализа и по меньшей мере одним другим компонентом, выбранным из группы, включающей:
электролит;
соединение-метку, содержащее ECL-часть молекулы;
представляющий интерес аналит или аналог представляющего интерес аналита;
партнер связывания представляющего интерес аналита или его аналога;
реакционноспособный компонент, способный взаимодействовать с (с) или (d);
(f) восстановитель; и
(g) усилитель электрохемилюминесцентной реакции;
при условии, однако, что никакие два компонента, содержащиеся в той или иной композиции реагента, не являются реакционноспособными в отношении друг друга во время хранения так, чтобы ухудшить их функцию в предполагаемом анализе.15. Composition for use as a reagent based on the use of microparticles of the binding analysis containing functionalized graphite nanotubes associated with the substance for analysis and at least one other component selected from the group including:
electrolyte;
a label compound containing an ECL moiety;
an analyte of interest or an analogue of an analyte of interest;
a binding partner for the analyte of interest or its analogue;
a reactive component capable of interacting with (c) or (d);
(f) a reducing agent; and
(g) an electrochemiluminescent reaction enhancer;
provided, however, that no two components contained in a particular reagent composition are reactive with respect to each other during storage so as to impair their function in the intended assay. 16. Композиция по п. 15, отличающаяся тем, что реагент содержит магнито-чувствительные графитовые нанотрубки. 16. The composition according to p. 15, characterized in that the reagent contains magnetically sensitive graphite nanotubes. 17. Тест-реагент для анализа, основанного на реакции связывания и измерении явления электрохемилюминесценции, содержащий электролит, множество магнито-чувствительных функционализованных графитовых нанотрубок, связанных с веществом для проведения анализа, и вещество для проведения анализа, связанное с химической частью молекулы, имеющей электрохемилюминесцентные свойства. 17. Test reagent for analysis based on the binding reaction and measurement of the phenomenon of electrochemiluminescence, containing an electrolyte, many magnetically sensitive functionalized graphite nanotubes associated with the substance for analysis, and the substance for analysis associated with the chemical part of the molecule having electrochemiluminescent properties . 18. Способ выполнения анализа для представляющего интерес аналита, присутствующего в пробе, предусматривающий следующие стадии образование композиции, содержащей эту пробу, и функционализованную графитовую нанотрубку, связанную с компонентом, который связан с соединением-меткой, способным индуцироваться для люминесценции, причем указанный компонент представляет собой субстрат представляющего интерес аналита, инкубирование указанной композиции при условиях, позволяющих аналиту расщеплять упомянутый компонент, отделение графитовой нанотрубки от композиции, индуцирование свободного соединения-метки для люминесценции, и измерение испускаемой люминесценции для измерения присутствия представляющего интерес аналита в пробе. 18. A method for performing an analysis for an analyte of interest present in a sample, comprising the steps of forming a composition containing this sample and a functionalized graphite nanotube associated with a component that is coupled to a label compound capable of being induced for luminescence, said component being substrate of analyte of interest, incubation of said composition under conditions allowing the analyte to cleave said component, separating graphite nanotubes from the composition, inducing the free label compound for luminescence, and measuring the emitted luminescence to measure the presence of the analyte of interest in the sample.
RU98116668/28A 1996-03-06 1997-03-05 Graphite natotubes in luminescent analyses and methods for conducting such analyses RU2189043C2 (en)

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US08/611,347 US5866434A (en) 1994-12-08 1996-03-06 Graphitic nanotubes in luminescence assays

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