RU98108032A - NEW LIQUID STABLE COMPOSITIONS BASED ON PARACETAMOL AND METHOD FOR PRODUCING THEM - Google Patents

NEW LIQUID STABLE COMPOSITIONS BASED ON PARACETAMOL AND METHOD FOR PRODUCING THEM

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Publication number
RU98108032A
RU98108032A RU98108032/14A RU98108032A RU98108032A RU 98108032 A RU98108032 A RU 98108032A RU 98108032/14 A RU98108032/14 A RU 98108032/14A RU 98108032 A RU98108032 A RU 98108032A RU 98108032 A RU98108032 A RU 98108032A
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RU
Russia
Prior art keywords
paracetamol
stable liquid
new stable
compositions based
liquid compositions
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Application number
RU98108032/14A
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Russian (ru)
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RU2192249C2 (en
Inventor
Диетлэн Франсуа
Фредж Даниель
Original Assignee
СКР Фарматоп
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Publication date
Priority claimed from FR9609858A external-priority patent/FR2751875B1/en
Application filed by СКР Фарматоп filed Critical СКР Фарматоп
Publication of RU98108032A publication Critical patent/RU98108032A/en
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Publication of RU2192249C2 publication Critical patent/RU2192249C2/en

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Claims (27)

1. Новые стабильные жидкие композиции на основе парацетамола в водосодержащем растворителе.1. New stable liquid compositions based on paracetamol in an aqueous solvent. 2. Новые стабильные жидкие композиции на основе парацетамола по п.1, в которых водосодержащий растворитель представляет собой смесь, содержащую воду и многоатомный спирт или алканол. 2. New stable liquid paracetamol-based compositions according to claim 1, wherein the aqueous solvent is a mixture comprising water and a polyhydric alcohol or alkanol. 3. Новые стабильные жидкие композиции на основе парацетамола по пп.1 и 2, в водосодержащем растворителе, отличающиеся тем, что кислород из водосодержащего растворителя удаляют путем барботирования инертным газом, нерастворимым в воде. 3. New stable liquid compositions based on paracetamol according to claims 1 and 2, in an aqueous solvent, characterized in that oxygen is removed from the aqueous solvent by sparging with an inert gas insoluble in water. 4. Новые стабильные жидкие композиции на основе парацетамола по одному из пп.1-3, в которых рН водосодержащего растворителя устанавливают с помощью буферного раствора 4 - 8. 4. New stable liquid compositions based on paracetamol according to one of claims 1 to 3, in which the pH of the aqueous solvent is adjusted using a buffer solution 4-8. 5. Новые стабильные жидкие композиции на основе парацетамола по одному из пп.1-4, в которых буферный растворитель имеет рН порядка 6,0. 5. New stable liquid compositions based on paracetamol according to one of claims 1 to 4, in which the buffer solvent has a pH of about 6.0. 6. Новые стабильные жидкие композиции на основе парацетамола по одному из пп.1-4, в которые добавляют дополнительно, по меньшей мере, один агент - поглотитель свободных радикалов. 6. New stable liquid paracetamol-based compositions according to one of claims 1 to 4, to which at least one additional free radical scavenger is added. 7. Новые стабильные жидкие композиции на основе парацетамола по п.6, в которых поглотитель свободных радикалов выбирают из производных аскорбиновой кислоты, органических соединений, несущих, по меньшей мере, одну тиоловую группу, и многоатомных спиртов. 7. New stable liquid compositions based on paracetamol according to claim 6, in which the free radical scavenger is selected from derivatives of ascorbic acid, organic compounds bearing at least one thiol group, and polyhydric alcohols. 8. Новые стабильные жидкие композиции на основе парацетамола по п.6 или 7, в которых производные аскорбиновой кислоты выбирают в группе, образованной D-аcкорбиновой кислотой, L-аскорбиновой кислотой, аскорбатами щелочного металла, аскорбатами щелочноземельного металла и сложными эфирами аскорбиновой кислоты, растворимыми в водной среде. 8. New stable liquid paracetamol-based compositions according to claim 6 or 7, wherein ascorbic acid derivatives are selected from the group consisting of D-ascorbic acid, L-ascorbic acid, alkali metal ascorbates, alkaline earth metal ascorbates and ascorbic acid esters soluble in the aquatic environment. 9. Новые стабильные жидкие композиции на основе парацетамола по п.6, в которых органическое соединение, несущее тиоловую группу, выбирают из соединений алифатического или циклического ряда, несущих одну или несколько тиоловых групп. 9. New stable liquid compositions based on paracetamol according to claim 6, in which the organic compound bearing a thiol group is selected from compounds of an aliphatic or cyclic series bearing one or more thiol groups. 10. Новые стабильные жидкие композиции на основе парацетамола по пп.6 и 9, в которых соединение, несущее тиоловую группу, выбирают в группе, образованной из тиогликолевой кислоты, тиомолочной кислоты, дитиотреитола, восстановленного глутатиона, тиомочевины, α--тиоглицерина, цистеина, ацетилцистеина и меркаптоэтановой сульфоновой кислоты. 10. New stable liquid compositions based on paracetamol according to claims 6 and 9, in which a compound bearing a thiol group is selected in the group formed from thioglycolic acid, thiolactic acid, dithiothreitol, reduced glutathione, thiourea, α-thioglycerol, cysteine, acetylcysteine and mercaptoethane sulfonic acid. 11. Новые стабильные жидкие композиции на основе парацетамола по пп.6 и 7, в которых многоатомный спирт - это алифатический полигидроксилированный спирт, содержащий 2 - 10 атомов углерода. 11. New stable liquid compositions based on paracetamol according to claims 6 and 7, in which the polyhydric alcohol is an aliphatic polyhydroxylated alcohol containing 2 to 10 carbon atoms. 12. Новые стабильные жидкие композиции на основе парацетамола по пп.6 и 7, в которых многоатомный спирт - это сахар или глюцитол, линейный или циклический, содержащий 2 - 10 атомов углерода, выбираемый из маннита, сорбита, инозита и глюкозы. 12. New stable liquid compositions based on paracetamol according to claims 6 and 7, in which the polyhydric alcohol is sugar or glucitol, linear or cyclic, containing 2 to 10 carbon atoms, selected from mannitol, sorbitol, inositol and glucose. 13. Новые стабильные жидкие композиции на основе парацетамола по п.12, в которых многоатомный спирт - это глицерин. 13. New stable liquid compositions based on paracetamol according to item 12, in which the polyhydric alcohol is glycerol. 14. Новые стабильные жидкие композиции на основе парацетамола по одному из пп.1-13, отличающиеся тем, что они содержат также, по меньшей мере, один комплексообразующий агент. 14. New stable liquid compositions based on paracetamol according to one of claims 1 to 13, characterized in that they also contain at least one complexing agent. 15. Новые стабильные жидкие композиции на основе парацетамола по одному из пп.1-14, в которых концентрация парацетамола изменяется 2 - 50 мг/мл для разбавленных растворов. 15. New stable liquid compositions based on paracetamol according to one of claims 1 to 14, in which the concentration of paracetamol varies from 2 to 50 mg / ml for diluted solutions. 16. Новые стабильные жидкие композиции на основе парацетамола по одному из пп. 1-14, в которых концентрация парацетамола изменяется 60 - 350 мг/мл для концентрированных растворов. 16. New stable liquid compositions based on paracetamol according to one of claims. 1-14, in which the concentration of paracetamol varies from 60 to 350 mg / ml for concentrated solutions. 17. Новые стабильные жидкие композиции на основе парацетамола по одному из пп. 1-14, в которые добавляют к препарату достаточное количество изотонизирующего агента. 17. New stable liquid compositions based on paracetamol according to one of claims. 1-14, in which a sufficient amount of an isotonizing agent is added to the preparation. 18. Новые стабильные жидкие композиции на основе парацетамола по одному из пп.1-14, отличающиеся тем, что для парентерального введения растворы стерилизуют путем нагревания. 18. New stable liquid compositions based on paracetamol according to one of claims 1 to 14, characterized in that for parenteral administration, the solutions are sterilized by heating. 19. Новые стабильные жидкие композиции на основе парацетамола по одному из пп.1-14, отличающиеся тем, что они содержат также болеутоляющее широкого действия, как например, морфиновый анальгетик. 19. New stable liquid compositions based on paracetamol according to one of claims 1 to 14, characterized in that they also contain a broad-spectrum painkiller, such as a morphine analgesic. 20. Новые стабильные жидкие композиции на основе парацетамола по п.19, в которых морфиновым анальгетиком является морфиновое производное, полученное путем экстракции, полусинтетическим или синтетическим путем производное фенилпиперидина, производное нипекотиновой кислоты, производное фенилциклогексанола или производное фенилазепина. 20. The new stable liquid paracetamol-based compositions according to claim 19, wherein the morphine analgesic is a morphine derivative obtained by extraction, a semisynthetic or synthetic derivative, a phenylpiperidine derivative, a nipecotinic acid derivative, a phenylcyclohexanol derivative or a phenylazepine derivative. 21. Новые стабильные жидкие композиции на основе парацетамола по п.19, в которых морфиновый анальгетик присутствует в дозе 0,05 - 5% парацетамола, в случае использования морфина, и 0,2 - 2,5%, в случае использования кодеина. 21. New stable liquid compositions based on paracetamol according to claim 19, in which the morphine analgesic is present in a dose of 0.05 - 5% paracetamol, in the case of morphine, and 0.2 - 2.5%, in the case of codeine. 22. Новые стабильные жидкие композиции на основе парацетамола по одному из пп. 1-14, отличающиеся тем, что они содержат также противовоспалительный агент фенилуксусного ряда. 22. New stable liquid compositions based on paracetamol according to one of claims. 1-14, characterized in that they also contain an anti-inflammatory agent of the phenylacetic series. 23. Новые стабильные жидкие композиции на основе парацетамола по п.22, отличающиеся тем, что противовоспалительным агентом является кетопрофен. 23. New stable liquid compositions based on paracetamol according to item 22, wherein the anti-inflammatory agent is ketoprofen. 24. Новые стабильные жидкие композиции на основе парацетамола по одному из пп.1-14, отличающиеся тем, что они содержат также противорвотный агент. 24. New stable liquid compositions based on paracetamol according to one of claims 1 to 14, characterized in that they also contain an antiemetic agent. 25. Новые стабильные жидкие композиции на основе парацетамола по одному из пп. 1-14, отличающиеся тем, что они содержат также противоэпилептический агент. 25. New stable liquid compositions based on paracetamol according to one of claims. 1-14, characterized in that they also contain an antiepileptic agent. 26. Новые стабильные жидкие композиции на основе парацетамола по одному из пп.1-14, отличающиеся тем, что они содержат также кортикостероид. 26. New stable liquid compositions based on paracetamol according to one of claims 1 to 14, characterized in that they also contain a corticosteroid. 27. Новые стабильные жидкие композиции на основе парацетамола по одному из пп. 1-14, отличающиеся тем, что они содержат также трициклический антидепрессивный агент. 27. New stable liquid compositions based on paracetamol according to one of claims. 1-14, characterized in that they also contain a tricyclic antidepressant agent.
RU98108032/14A 1996-08-05 1997-08-05 Paracetamol-base liquid stable composition and method of its preparing RU2192249C2 (en)

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Application Number Priority Date Filing Date Title
FR9609858A FR2751875B1 (en) 1996-08-05 1996-08-05 NOVEL STABLE LIQUID FORMULATIONS BASED ON PARACETAMOL AND THEIR METHOD OF PREPARATION
FR9609858 1996-08-05

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Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6160020A (en) * 1996-12-20 2000-12-12 Mcneill-Ppc, Inc. Alkali metal and alkaline-earth metal salts of acetaminophen
US8524277B2 (en) 1998-03-06 2013-09-03 Alza Corporation Extended release dosage form
US6245357B1 (en) * 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
FR2779061B1 (en) * 1998-04-14 2004-08-20 Pharmatop NOVEL METHOD FOR STABILIZING PHENOLIC COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS THEREFROM
IT1301976B1 (en) * 1998-07-31 2000-07-20 Angelini Ricerche Spa INJECTABLE PHARMACEUTICAL COMPOSITION BASED ON PARACETAMOL
ES2258675T3 (en) * 1999-05-28 2006-09-01 Novartis Ag PROCESS FOR THE MANUFACTURE OF A COMPRESSIBLE STERILE PACKAGING FOR A PHARMACEUTICAL PRODUCT.
DE19932157A1 (en) * 1999-07-13 2001-01-18 Pharmasol Gmbh Process for the gentle production of ultra-fine microparticles and nanoparticles
US6334859B1 (en) 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
IT1313579B1 (en) * 1999-07-30 2002-09-09 Acraf PARACETAMOL-BASED LIQUID PHARMACEUTICAL COMPOSITION.
GB0006897D0 (en) * 2000-03-23 2000-05-10 Smithkline Beecham Plc Medicaments
FR2809619B1 (en) * 2000-06-06 2004-09-24 Pharmatop NOVEL AQUEOUS FORMULATIONS OF OXIDATION-SENSITIVE ACTIVE INGREDIENTS AND PROCESS FOR OBTAINING THEM
AU2006203741B2 (en) * 2000-06-06 2009-11-05 Scr Pharmatop Method for obtaining aqueous formulations with active principles susceptible to oxidation and the aqueous solutions thus obtained
DE10112325A1 (en) * 2001-03-13 2002-10-02 Fresenius Kabi De Gmbh Storage stable ready-to-use infusion solutions of paracetamol
ITMI20012135A1 (en) 2001-10-16 2003-04-16 Bioren S A INJECTABLE SOLUTIONS READY TO USE PARACETAMOL
WO2003051398A1 (en) * 2001-12-18 2003-06-26 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Parenteral composition of paracetamol
FR2851164B1 (en) * 2003-02-14 2005-04-22 Xuan Tho Nguyen INFLATABLE LIQUID FORMULATION OF PARACETAMOL
BG65674B1 (en) * 2003-07-10 2009-06-30 Нихфи Ад Liquid form of combined medicamentous preparation for the treatment of colds and flue diseases
ES2287658T3 (en) * 2004-03-10 2007-12-16 Shimoda Biotech (Pty) Ltd STABLE INJECTABLE COMPOSITIONS OF DICLOFENAC.
US20060205752A1 (en) * 2005-03-14 2006-09-14 Keith Whitehead Stabilized hydrocodone pharmaceutical compositions with ethylenediaminetetraacetic acid
DE102005037653A1 (en) * 2005-08-05 2007-02-15 Theraselect Gmbh Stable, liquid formulation of paracetamol
US20070098790A1 (en) * 2005-10-31 2007-05-03 David Jiang Nutritional supplement for the enhancement of the health of the liver
FR2894154B1 (en) * 2005-12-06 2008-03-14 Pharmatop Scr NOVEL METHOD FOR STABILIZING OXIDATION - SENSITIVE MINERAL OR ORGANIC SUBSTANCES.
WO2007112272A2 (en) * 2006-03-28 2007-10-04 Javelin Pharmaceuticals, Inc. Formulations of low dose diclofenac and beta-cyclodextrin
US20070249727A1 (en) 2006-04-21 2007-10-25 The Proctor & Gamble Company Compositions and kits useful for treatment of respiratory illness
US10022339B2 (en) 2006-04-21 2018-07-17 The Procter & Gamble Company Compositions and methods useful for treatment of respiratory illness
US9943479B2 (en) * 2006-07-18 2018-04-17 Genfarma Laboratorio S.L. Injectable liquid paracetamol formulation
EP1992334A1 (en) * 2007-05-08 2008-11-19 Docpharma NV/SA Storage-stable formulation of oxidation-sensitive phenolic drug, especially paracetamol, comprises aqueous drug solution deoxygenated by a temperature-controlled manufacturing process of the formulation
WO2009047634A2 (en) * 2007-06-18 2009-04-16 Combino Pharm, S.L. Aqueous formulations of acetaminophen for injection
WO2009081283A2 (en) * 2007-06-18 2009-07-02 Combino Pharm, S.L. Aqueous formulations of acetaminophen for injection
JP5909750B2 (en) * 2007-11-13 2016-04-27 マリンクロット アイピー Low dose intravenous acetaminophen
WO2009098716A2 (en) * 2008-01-17 2009-08-13 Aptuit Laurus Private Limited Stable pharmaceutical aqueous compositions
FR2926992B1 (en) * 2008-02-06 2011-01-14 Moly Pharma FORMULATION OF AN INJECTABLE PARACETAMOL SOLUTION, PROCESS FOR PREPARING AND PACKAGING SUCH A SOLUTION AND DEVICE FOR CONDITIONING SUCH A SOLUTION
WO2009157010A1 (en) * 2008-06-25 2009-12-30 Akums Drugs And Pharmaceuticals Limited An intravenous drug delivery system
WO2009157009A1 (en) * 2008-06-25 2009-12-30 Akums Drugs And Pharmaceuticals Limited An intravenous drug delivery system
EP2243477A1 (en) 2009-04-22 2010-10-27 Fresenius Kabi Deutschland GmbH Paracetamol for parenteral application
JP2012533559A (en) * 2009-07-15 2012-12-27 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ N-acetylcysteine composition and method for improving the therapeutic effect of acetaminophen
EP2277546B1 (en) * 2009-07-23 2015-07-15 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Stable ready to use injectable paracetamol formulation
EP2464332B1 (en) 2009-08-13 2016-03-02 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
US8404748B2 (en) * 2009-08-13 2013-03-26 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
FR2950533B1 (en) * 2009-09-28 2012-01-13 Maco Pharma Sa LIQUID FORMULATION, STABLE, READY TO USE KETOPROFEN
EP2308463A1 (en) * 2009-10-12 2011-04-13 EMP Pharma GmbH Aqueous acetaminophen compositions and method of preparation
US20120245230A1 (en) 2009-12-10 2012-09-27 Tecnimede-Sociedade Tecnico- Medicinal, S.A. Method and composition for preparing stable liquid formulations of paracetamol
RU2446799C2 (en) * 2010-01-22 2012-04-10 Анатолий Брониславович Гаврилов Antioxidant composition
US20110207824A1 (en) * 2010-02-25 2011-08-25 Moly Pharma Formulation of an injectable paracetamol solution, method for preparing and packaging such a solution and device for packaging such a solution
ES2389760T3 (en) 2010-04-14 2012-10-31 B. Braun Melsungen Ag Acetaminophen Composition
GR1007315B (en) * 2010-04-19 2011-06-14 Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε Με Δ.Τ. Uni-Pharma Abee, A parenteral-administration tramadol-and-paracetamol liquid composition
EP2389923B1 (en) * 2010-05-19 2013-01-30 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Stable ready to use injectable paracetamol formulation
EP2389931A1 (en) 2010-05-21 2011-11-30 Raw Materials Internatinal LLC Pharmaceutical aqueous compositions comprising lipoic acid as an antioxidant
PL2588097T3 (en) * 2010-06-30 2021-09-06 Troikaa Pharmaceuticals Limited Pharmaceutical compositions comprising paracetamol and process for preparing the same
KR20130132496A (en) 2010-12-09 2013-12-04 마루이시세이야쿠가부시키가이샤 Stabilizer of acetaminophen
CN102600068A (en) * 2011-01-24 2012-07-25 联康药业克雷恩特塞提斯制药实验室有限责任公司 Stable ready-to-use paracetamol preparation capable of being injected
AU2011200289B2 (en) * 2011-01-24 2016-10-13 Ioulia Tseti Stable ready to use injectable paracetamol formulation
CA2827062A1 (en) 2011-02-10 2012-08-16 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
ES2414557B1 (en) 2012-01-16 2014-06-10 Novocat Farma, S.A. Aqueous composition of paracetamol for injection
ITMI20121154A1 (en) 2012-06-29 2013-12-30 Sint Sa INJECTABLE ACETAMINOFENE SOLUTION FOR SPINAL ADMINISTRATION
US8568747B1 (en) 2012-10-05 2013-10-29 Silvergate Pharmaceuticals, Inc. Enalapril compositions
ZA201300398B (en) 2012-11-27 2013-09-25 Genfarma Laboratories S L Injectable liquid formulation of the combination of tramadol and paracetamol
PL3639828T3 (en) 2013-12-24 2022-05-02 Virginia Commonwealth University Use of oxygenated cholesterol sulfates (ocs) for treating acute liver failure
BR102014005885B1 (en) 2014-03-13 2021-04-13 Biotec Biológica Indústria Farmacêutica Ltda E.P.P STABLE INJECTABLE LIQUID PHARMACEUTICAL FORMULATION OF PARACETAMOL IN PLASTIC BAG READY FOR USE
EP3171868B1 (en) 2014-07-25 2020-09-30 Terumo Kabushiki Kaisha Packaged acetaminophen injection solution preparation
MA40599A1 (en) 2014-12-20 2017-11-30 Troikaa Pharmaceuticals Ltd Injectable Formulations of Paracetamol
US9463183B1 (en) 2015-10-30 2016-10-11 Silvergate Pharmaceuticals, Inc. Lisinopril formulations
MX2018009497A (en) 2016-02-05 2019-05-06 Innopharma Inc Process of manufacturing a stable, ready to use infusion bag for an oxidation sensitive formulation.
US9669008B1 (en) 2016-03-18 2017-06-06 Silvergate Pharmaceuticals, Inc. Enalapril formulations
KR20190057349A (en) * 2016-09-23 2019-05-28 그뤼넨탈 게엠베하 Stable formulation for parenteral administration of tapentadol
CN110214004B (en) * 2017-01-24 2022-11-22 株式会社优盛制药 Injectable composition containing acetaminophen
CA3051467C (en) 2017-01-30 2022-11-29 Nevakar, Inc Norepinephrine compositions and methods therefor
WO2018192664A1 (en) * 2017-04-20 2018-10-25 Hyloris Developments Sa METHOD FOR PREPARING A COMPOSITION WITH A LOW DISSOLVED OXYGEN CONTENT, COMPRISING ACETAMINOPHEN, AND OPTIONALLY ONE OR MORE NSAIDs, AND A COMPOSITION OBTAINED THEREOF
RU2737852C2 (en) * 2017-12-28 2020-12-03 Беккер Герман Петрович Method of producing a drug based on oligopeptide alloferon-1, having an antiviral and immunomodulating effect, and prolonged storage medicinal product obtained with its help
CN115385818B (en) * 2022-09-01 2023-09-29 江苏海洋大学 Paracetamol impurity and preparation method thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314989A (en) * 1980-05-07 1982-02-09 Rosen Gerald M Methionine sulfoxide amflioration of acetaminophen toxicity
RO82841A2 (en) * 1981-08-04 1983-11-01 Intreprinderea De Medicamente "Biofarm",Ro SUSPENSION WITH PARACETAMOL
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4855326A (en) * 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
FR2646773B1 (en) * 1989-05-12 1994-05-13 Chauvin Sa Laboratoire PHARMACEUTICAL COMPOSITION BASED ON PARACETAMOL
JPH0714872B2 (en) * 1990-02-06 1995-02-22 昭和薬品化工株式会社 Syrup composition
JPH0672897A (en) * 1991-03-27 1994-03-15 Cullim & Assoc Inc Composition for reducing various unplesant symptoms before and during menstruation
US5252313A (en) * 1991-12-20 1993-10-12 Colgate-Palmolive Company Visually clear gel dentifrice
US5272137A (en) * 1992-02-14 1993-12-21 Mcneil-Pfc, Inc. Aqueous pharmaceutical suspension for pharmaceutical actives
US5474757A (en) * 1992-10-16 1995-12-12 Rutgers University Prevention of acetaminophen overdose toxicity with organosulfur compounds
EP0620001A1 (en) * 1993-04-16 1994-10-19 McNEIL-PPC, INC. Aqueous pharmaceutical suspension and process for preparation thereof
DE4327462A1 (en) * 1993-08-16 1995-02-23 Carl Heinrich Dr Weischer N-Acetyl-p-aminophenol derivatives for controlling pain
JPH07206689A (en) * 1994-01-21 1995-08-08 Barnett Lab Ltd Curing composition and use of this composition for curing crapulence
SK96196A3 (en) * 1994-01-24 1997-03-05 Procter & Gamble Process for solubilizing difficultly soluble pharmaceutical actives
US5510389A (en) * 1994-03-02 1996-04-23 The Procter & Gamble Company Concentrated acetaminophen solution compositions
JPH09286724A (en) * 1996-04-19 1997-11-04 Takeda Chem Ind Ltd Liquid stablizer for oral administration

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