RU98104924A - Isolation of Clavanic Acid from the Fermentation Bouillon by Ultrafiltration - Google Patents
Isolation of Clavanic Acid from the Fermentation Bouillon by UltrafiltrationInfo
- Publication number
- RU98104924A RU98104924A RU98104924/04A RU98104924A RU98104924A RU 98104924 A RU98104924 A RU 98104924A RU 98104924/04 A RU98104924/04 A RU 98104924/04A RU 98104924 A RU98104924 A RU 98104924A RU 98104924 A RU98104924 A RU 98104924A
- Authority
- RU
- Russia
- Prior art keywords
- ultrafiltration
- filtrate
- clavulanic acid
- isolation
- ester
- Prior art date
Links
- 238000000108 ultra-filtration Methods 0.000 title claims 7
- 238000000855 fermentation Methods 0.000 title claims 2
- 230000004151 fermentation Effects 0.000 title claims 2
- 238000002955 isolation Methods 0.000 title claims 2
- 239000002253 acid Substances 0.000 title 1
- 239000000706 filtrate Substances 0.000 claims 7
- 229960003324 Clavulanic Acid Drugs 0.000 claims 4
- HZZVJAQRINQKSD-PBFISZAISA-N Clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 2
- 238000002834 transmittance Methods 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000001471 micro-filtration Methods 0.000 claims 1
- 229920003288 polysulfone Polymers 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (9)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SIP-9500265 | 1995-08-28 | ||
SI9500265A SI9500265A1 (en) | 1995-08-28 | 1995-08-28 | Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration |
Publications (2)
Publication Number | Publication Date |
---|---|
RU98104924A true RU98104924A (en) | 1999-12-10 |
RU2169151C2 RU2169151C2 (en) | 2001-06-20 |
Family
ID=20431679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU98104924/04A RU2169151C2 (en) | 1995-08-28 | 1996-08-27 | Method of preparing and/or purification of clavulanic acid from fermentation broth by ultrafiltration |
Country Status (20)
Country | Link |
---|---|
US (2) | US6127358A (en) |
EP (1) | EP0859780A1 (en) |
JP (1) | JP2000512125A (en) |
KR (1) | KR19990035966A (en) |
CN (1) | CN1101396C (en) |
AU (1) | AU714892B2 (en) |
BG (1) | BG63086B1 (en) |
CA (1) | CA2226683C (en) |
CZ (1) | CZ31898A3 (en) |
EE (1) | EE03567B1 (en) |
HU (1) | HU221353B1 (en) |
NZ (1) | NZ316136A (en) |
PL (1) | PL324855A1 (en) |
RO (1) | RO116813B1 (en) |
RU (1) | RU2169151C2 (en) |
SI (1) | SI9500265A1 (en) |
SK (1) | SK10398A3 (en) |
UA (1) | UA59343C2 (en) |
WO (1) | WO1997008175A1 (en) |
ZA (1) | ZA967273B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT400033B (en) | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | NEW METHOD FOR ISOLATING AND PURIFYING CLAVULANIC ACID AND FOR PRODUCING PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF |
SI9500074A (en) * | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
AT403375B (en) * | 1995-11-15 | 1998-01-26 | Biochemie Gmbh | METHOD FOR FILLING ALKALINE SALTS OF CLAVULANIC ACID |
ES2105988B1 (en) * | 1996-03-15 | 1998-07-01 | Antibioticos Sa | PROCEDURE TO PURIFY 7-SUBSTITUTED-AMINO-DESACETOXI-CEPHALOSPORINS THROUGH THE USE OF FILTRATION MEMBRANES. |
GB0022841D0 (en) | 2000-09-18 | 2000-11-01 | Smithkline Beecham Plc | Process |
JP2004094465A (en) * | 2002-08-30 | 2004-03-25 | Fujitsu Ltd | Analysis support device |
WO2008132531A1 (en) * | 2007-04-27 | 2008-11-06 | Council Of Scientific And Industrial Research | Process for the preparation of clavulanic acid employing streptomyces clavuligerus mtcc 1142 in a solid state fermentation |
CN102838624B (en) * | 2012-09-07 | 2014-10-29 | 安徽普朗膜技术有限公司 | Method for purifying clavulanic acid from fermentation liquor |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3873425A (en) * | 1971-11-19 | 1975-03-25 | Tatsuyoshi Kobayashi | Process for producing itaconic acid |
GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
IE41110B1 (en) * | 1974-04-20 | 1979-10-24 | Beecham Group Ltd | Esters of clavulanic acid |
IE41109B1 (en) * | 1974-04-20 | 1979-10-24 | Beecham Group Ltd | Novel -lactam antibiotic from streptomyces clavuligerus |
US4140764A (en) * | 1974-12-18 | 1979-02-20 | Beecham Group Limited | β-Lactamase inhibitors and process for their preparation |
US4148880A (en) * | 1975-08-13 | 1979-04-10 | Pfizer Inc. | Mixture of antibiotics produced by a species of actinoplanes |
GB1563103A (en) * | 1975-10-13 | 1980-03-19 | Beecham Group Ltd | Process for the preparation of clavulanic acid |
GB1578739A (en) * | 1976-07-23 | 1980-11-05 | Beecham Group Ltd | Amine salts of clavulanic acid methods for their preparation and compositions containing them |
JPS5791196A (en) * | 1980-11-27 | 1982-06-07 | Takeda Chem Ind Ltd | Separation of inosine, guanosine or their mixture from cell bodies and high polymeric substances |
JPS6070092A (en) * | 1983-09-26 | 1985-04-20 | Ajinomoto Co Inc | Collection of crystals of glutamic acid from its fermentation solution |
MX7417E (en) * | 1984-10-27 | 1988-10-14 | Antibioticos Sa | METHOD FOR THE PREPARATION OF CLAVULANIC ACID AND ITS DERIVATIVES |
IT1221982B (en) * | 1987-07-08 | 1990-08-31 | Mini Ricerca Scient Tecnolog | ANTIBIOTICS AB 006 AND PROCESS FOR THEIR PRODUCTION |
DE3730868A1 (en) * | 1987-09-15 | 1989-03-23 | Henkel Kgaa | METHOD FOR SEPARATING BIOTECHNICALLY MANUFACTURED VALUABLES FROM A FERMENTERBRUSS BY CROSS-CURRENT MICRO- AND / OR ULTRAFILTRATION |
ES2010144A6 (en) * | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | A process of flocculation-coagulation of fermentation broths of streptomyces sp. which permits direct obtainment of completely transparent liquids. |
US5024937A (en) * | 1989-04-06 | 1991-06-18 | Dow Corning Corporation | Method for processing aqueous fermentation broths |
EP0431679B1 (en) * | 1989-12-05 | 1994-10-19 | Merck & Co. Inc. | Method of stabilizing recombinant hepatitis B virus surface proteins from yeast |
JPH0475595A (en) * | 1990-07-17 | 1992-03-10 | Kanebo Ltd | Production of phenylglycoside |
US5268283A (en) * | 1990-10-05 | 1993-12-07 | Miles Inc. | Method for the production of detergent builder formulations utilizing spray granulated citric acid and salts thereof |
DE4031854A1 (en) * | 1990-10-08 | 1992-04-09 | Basf Ag | MICROORGANISM AND METHOD FOR OBTAINING ANTHRANILIC ACID |
JP2615272B2 (en) | 1991-03-22 | 1997-05-28 | 日本碍子株式会社 | Method for recovering protein valuables from protein solution |
AT399155B (en) * | 1992-03-26 | 1995-03-27 | Lek Tovarna Farmacevtskih | NEW ALKYLENE DIAMMONIUM DICLAVULANATE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF |
SI9300296B (en) | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Process and intermediates for the preparation of clavulanic acid |
AU682030B2 (en) * | 1993-03-26 | 1997-09-18 | Dsm N.V. | Diamine salts of clavulanic acid |
WO1995011295A1 (en) * | 1993-10-22 | 1995-04-27 | Gist-Brocades N.V. | An improved process to recover an aqueous fermentation broth |
AT400846B (en) * | 1994-02-25 | 1996-03-25 | Fermic S A De C V | Method for isolating and purifying alkali metal salts of clavulanic acid |
SI9400107A (en) * | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
JP3617091B2 (en) * | 1994-11-30 | 2005-02-02 | 味の素株式会社 | Purification method of basic amino acids |
SI9500074A (en) * | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
SI9500134B (en) * | 1995-04-20 | 2004-04-30 | Lek, | Preparation procedure of pure alkali salts of clavulanic acid |
ES2101658B1 (en) * | 1995-11-23 | 1998-03-01 | Antibioticos Sa | NEW PROCEDURE FOR THE PRODUCTION OF CLAVULANIC ACID AND ITS SALTS. |
-
1995
- 1995-08-28 SI SI9500265A patent/SI9500265A1/en not_active IP Right Cessation
-
1996
- 1996-08-27 WO PCT/GB1996/002083 patent/WO1997008175A1/en not_active Application Discontinuation
- 1996-08-27 CZ CZ98318A patent/CZ31898A3/en unknown
- 1996-08-27 JP JP09509986A patent/JP2000512125A/en not_active Ceased
- 1996-08-27 RO RO98-00301A patent/RO116813B1/en unknown
- 1996-08-27 CA CA002226683A patent/CA2226683C/en not_active Expired - Fee Related
- 1996-08-27 EP EP96928571A patent/EP0859780A1/en not_active Withdrawn
- 1996-08-27 RU RU98104924/04A patent/RU2169151C2/en not_active IP Right Cessation
- 1996-08-27 PL PL96324855A patent/PL324855A1/en unknown
- 1996-08-27 SK SK103-98A patent/SK10398A3/en unknown
- 1996-08-27 EE EE9800060A patent/EE03567B1/en not_active IP Right Cessation
- 1996-08-27 UA UA98020991A patent/UA59343C2/en unknown
- 1996-08-27 NZ NZ316136A patent/NZ316136A/en unknown
- 1996-08-27 HU HU9802532A patent/HU221353B1/en not_active IP Right Cessation
- 1996-08-27 CN CN96196471A patent/CN1101396C/en not_active Expired - Fee Related
- 1996-08-27 AU AU68297/96A patent/AU714892B2/en not_active Ceased
- 1996-08-27 US US09/000,375 patent/US6127358A/en not_active Expired - Fee Related
- 1996-08-27 KR KR1019980700627A patent/KR19990035966A/en not_active Application Discontinuation
- 1996-08-28 ZA ZA9607273A patent/ZA967273B/en unknown
-
1998
- 1998-02-16 BG BG102253A patent/BG63086B1/en unknown
-
2000
- 2000-08-14 US US09/638,473 patent/US6274575B1/en not_active Expired - Lifetime
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2948661B2 (en) | Streptomyces sp. Novel method for separating clavulanic acid and its pharmaceutically applicable salts from fermentation broth of P6621 FERM P2804 | |
CA2352242A1 (en) | Ultrafiltration and microfiltration module and system | |
RU98104924A (en) | Isolation of Clavanic Acid from the Fermentation Bouillon by Ultrafiltration | |
WO1999061647A8 (en) | Electrodialysis methods for purification and recovery of gluconic acid derivatives | |
CA2226683A1 (en) | Isolation of clavulanic acid from fermentation broth by ultrafiltration | |
CA2328176A1 (en) | Method for purifying alkali metal silicate solutions | |
JPS6240261A (en) | Decoloration of liquid food | |
RU97110639A (en) | METHOD FOR OBTAINING COMPLEX FERTILIZER | |
JPH11215980A (en) | Treatment of liquid containing microbial cell | |
SU981245A1 (en) | Method for decontaminating water from viruses | |
RU96114341A (en) | METHOD FOR PRODUCING LEMONIC ACID | |
RU2001129862A (en) | The method of producing citric acid | |
RU99103689A (en) | METHOD FOR OBTAINING 3-HYDROXYMETHILTSEFALOSPORINS | |
RU2000113669A (en) | METHOD FOR PRODUCING LIQUID ENZYME DRUGS | |
RU92001860A (en) | METHOD FOR OBTAINING RIBONUCLEIC ACID AND PURIFIED YEAST EXTRACT | |
TH3258B (en) | Methods for separating basicaminophasic from inoculation. | |
RU96111891A (en) | METHOD FOR PRODUCING GLUCOSE FROM STARCH | |
BG60460B1 (en) | Method for the purification and cleaning of lovastatin |