BG60460B1 - Method for the purification and cleaning of lovastatin - Google Patents
Method for the purification and cleaning of lovastatinInfo
- Publication number
- BG60460B1 BG60460B1 BG97660A BG9766093A BG60460B1 BG 60460 B1 BG60460 B1 BG 60460B1 BG 97660 A BG97660 A BG 97660A BG 9766093 A BG9766093 A BG 9766093A BG 60460 B1 BG60460 B1 BG 60460B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- lovastatin
- filtered
- extraction
- filtrate
- lactone
- Prior art date
Links
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Ловастатинът намира приложение в хуманната и ветеринарната медицина. Чрез метода се повишава добивът от крайния продукт. По него културален бульон (среда) се алкализира до рн 8,5 9. Мицелът се филтрира и се подлага на екстракционна обработка с алкална вода при стайна температура и рн 8,5-9. Следва ново филтриране. Филтратите от филтрацията на културалния бульон и екстракцията на мицела се смесват. Обединеният филтрат се подлага на пречистване, което може да бъде екстракционно в два варианта, или мембранно. Пречистеният филтрат се концентрира седновременна лактонизация на ловастатиновата киселина. През концентрата, съдържащ ловастатинлактон,се пропуска газообразен амоняк и образувалата се утайка от баластни вещества се филтрира. Филтратътсе концентрира повторно до 1/10 от първоначалния обем и се охлажда до -200с. Изкристализиралият ловастатинлактон се филтрира. Кристалите се сушат подвакуум и се подлагат на рекристализация из етилацетат, бутилацетат или етанол. Следва филтриране начистия ловастатинлактон и сушене под вакуум.Lovastatin is used in human and veterinary medicine. The method increases the yield of the final product. The culture broth (medium) is basified to pH 8.5. The mycelia is filtered and subjected to extraction treatment with alkaline water at room temperature and pH 8.5-9. There is a new filtering. The filtrates of the culture broth filtration and mycelial extraction are mixed. The combined filtrate is subjected to purification, which can be extraction in two variants, or membrane. The purified filtrate concentrated concurrent laconylation of lovastatin acid. Gaseous ammonia is passed through the concentrate containing lovastatin lactone and the resulting ballast residue is filtered. The filtrate is again concentrated to 1/10 of the original volume and cooled to -200 ° C. The crystallized lovastatin lactone is filtered. The crystals were dried under vacuum and recrystallized from ethyl acetate, butyl acetate or ethanol. Filtration of lovastatin lactone and drying under vacuum was then performed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG97660A BG60460B1 (en) | 1993-04-23 | 1993-04-23 | Method for the purification and cleaning of lovastatin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG97660A BG60460B1 (en) | 1993-04-23 | 1993-04-23 | Method for the purification and cleaning of lovastatin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG97660A BG97660A (en) | 1994-08-30 |
| BG60460B1 true BG60460B1 (en) | 1995-04-28 |
Family
ID=3925098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG97660A BG60460B1 (en) | 1993-04-23 | 1993-04-23 | Method for the purification and cleaning of lovastatin |
Country Status (1)
| Country | Link |
|---|---|
| BG (1) | BG60460B1 (en) |
-
1993
- 1993-04-23 BG BG97660A patent/BG60460B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG97660A (en) | 1994-08-30 |
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