RU98103895A - Extended activity IPRATROPY BROMIDE ENANTIOMER - Google Patents
Extended activity IPRATROPY BROMIDE ENANTIOMERInfo
- Publication number
- RU98103895A RU98103895A RU98103895/04A RU98103895A RU98103895A RU 98103895 A RU98103895 A RU 98103895A RU 98103895/04 A RU98103895/04 A RU 98103895/04A RU 98103895 A RU98103895 A RU 98103895A RU 98103895 A RU98103895 A RU 98103895A
- Authority
- RU
- Russia
- Prior art keywords
- inhalation
- drugs
- butylamino
- hydroxy
- ethanol
- Prior art date
Links
- 150000001649 bromium compounds Chemical class 0.000 title 1
- -1 carterol Chemical compound 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drugs Drugs 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 239000000043 antiallergic agent Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003431 steroids Chemical class 0.000 claims 3
- 210000002345 respiratory system Anatomy 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- KOTMQCNDGLTIHR-UHFFFAOYSA-N 4-[2-[[4-(benzimidazol-1-yl)-2-methylbutan-2-yl]amino]-1-hydroxyethyl]-3-fluorophenol Chemical compound C1=NC2=CC=CC=C2N1CCC(C)(C)NCC(O)C1=CC=C(O)C=C1F KOTMQCNDGLTIHR-UHFFFAOYSA-N 0.000 claims 1
- ANZXOIAKUNOVQU-UHFFFAOYSA-N Bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 claims 1
- 229940092705 Beclomethasone Drugs 0.000 claims 1
- FZGVEKPRDOIXJY-UHFFFAOYSA-N Bitolterol Chemical compound C1=CC(C)=CC=C1C(=O)OC1=CC=C(C(O)CNC(C)(C)C)C=C1OC(=O)C1=CC=C(C)C=C1 FZGVEKPRDOIXJY-UHFFFAOYSA-N 0.000 claims 1
- 229960004436 Budesonide Drugs 0.000 claims 1
- KEMXXQOFIRIICG-UHFFFAOYSA-N Carbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(NC(N)=O)=C1 KEMXXQOFIRIICG-UHFFFAOYSA-N 0.000 claims 1
- STJMRWALKKWQGH-UHFFFAOYSA-N Clenbuterol Chemical compound CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 STJMRWALKKWQGH-UHFFFAOYSA-N 0.000 claims 1
- BQTXJHAJMDGOFI-NJLPOHDGSA-N Dexamethasone isonicotinate Chemical compound O=C([C@]1(O)[C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)COC(=O)C1=CC=NC=C1 BQTXJHAJMDGOFI-NJLPOHDGSA-N 0.000 claims 1
- WHWZLSFABNNENI-UHFFFAOYSA-N Epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 claims 1
- LSLYOANBFKQKPT-UHFFFAOYSA-N Fenoterol Chemical compound C=1C(O)=CC(O)=CC=1C(O)CNC(C)CC1=CC=C(O)C=C1 LSLYOANBFKQKPT-UHFFFAOYSA-N 0.000 claims 1
- BPZSYCZIITTYBL-YJYMSZOUSA-N Formoterol Chemical compound C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-YJYMSZOUSA-N 0.000 claims 1
- OXLZNBCNGJWPRV-UHFFFAOYSA-N Hexoprenaline Chemical compound C=1C=C(O)C(O)=CC=1C(O)CNCCCCCCNCC(O)C1=CC=C(O)C(O)=C1 OXLZNBCNGJWPRV-UHFFFAOYSA-N 0.000 claims 1
- 229950002451 Ibuterol Drugs 0.000 claims 1
- RQTOOFIXOKYGAN-UHFFFAOYSA-N Nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 claims 1
- VQDBNKDJNJQRDG-UHFFFAOYSA-N Pirbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=N1 VQDBNKDJNJQRDG-UHFFFAOYSA-N 0.000 claims 1
- WVLAAKXASPCBGT-UHFFFAOYSA-N Reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 claims 1
- 206010038683 Respiratory disease Diseases 0.000 claims 1
- YREYLAVBNPACJM-UHFFFAOYSA-N Tulobuterol Chemical compound CC(C)(C)NCC(O)C1=CC=CC=C1Cl YREYLAVBNPACJM-UHFFFAOYSA-N 0.000 claims 1
- WKHOPHIMYDJVSA-UHFFFAOYSA-N [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(2-methylpropanoyloxy)phenyl] 2-methylpropanoate Chemical compound CC(C)C(=O)OC1=CC(OC(=O)C(C)C)=CC(C(O)CNC(C)(C)C)=C1 WKHOPHIMYDJVSA-UHFFFAOYSA-N 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 229960003060 bambuterol Drugs 0.000 claims 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 1
- 229960004620 bitolterol Drugs 0.000 claims 1
- 229960001386 carbuterol Drugs 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229960001117 clenbuterol Drugs 0.000 claims 1
- 229960000265 cromoglicic acid Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 claims 1
- 229960003449 epinastine Drugs 0.000 claims 1
- 229960001022 fenoterol Drugs 0.000 claims 1
- 229960002848 formoterol Drugs 0.000 claims 1
- 229960000708 hexoprenaline Drugs 0.000 claims 1
- 229960004398 nedocromil Drugs 0.000 claims 1
- 229960005414 pirbuterol Drugs 0.000 claims 1
- 229960002720 reproterol Drugs 0.000 claims 1
- 229960000859 tulobuterol Drugs 0.000 claims 1
Claims (8)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19528145.4 | 1995-08-01 | ||
DE19528145A DE19528145A1 (en) | 1995-08-01 | 1995-08-01 | New drugs and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
RU98103895A true RU98103895A (en) | 2000-01-10 |
RU2171258C2 RU2171258C2 (en) | 2001-07-27 |
Family
ID=7768353
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU98103895/04A RU2171258C2 (en) | 1995-08-01 | 1996-07-31 | L-(-)-enantiomer bromide of (endo,syn)-(-)-3-(3-hydroxy-1- oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azonia- bicyclo-[3,2,1]-octane with purity 90-100% and inhalation preparation for inhibition of bronchial spasm induced by acetylcholine |
Country Status (37)
Country | Link |
---|---|
US (1) | US6299861B1 (en) |
EP (1) | EP0843676B1 (en) |
JP (1) | JPH11510150A (en) |
KR (1) | KR100445016B1 (en) |
CN (1) | CN1120841C (en) |
AR (1) | AR004179A1 (en) |
AT (1) | ATE208390T1 (en) |
AU (1) | AU6739796A (en) |
BG (1) | BG63780B1 (en) |
BR (1) | BR9609951A (en) |
CA (1) | CA2226934C (en) |
CO (1) | CO4750836A1 (en) |
CZ (1) | CZ291998B6 (en) |
DE (2) | DE19528145A1 (en) |
DK (1) | DK0843676T3 (en) |
EE (1) | EE04614B1 (en) |
ES (1) | ES2167592T3 (en) |
HK (2) | HK1013597A1 (en) |
HR (1) | HRP960365B1 (en) |
HU (1) | HU228056B1 (en) |
IL (1) | IL118986A (en) |
MX (1) | MX9800864A (en) |
MY (1) | MY115201A (en) |
NO (1) | NO317561B1 (en) |
NZ (1) | NZ315645A (en) |
PL (1) | PL183789B1 (en) |
PT (1) | PT843676E (en) |
RO (1) | RO120260B1 (en) |
RU (1) | RU2171258C2 (en) |
SI (1) | SI0843676T1 (en) |
SK (1) | SK283260B6 (en) |
TR (1) | TR199800121T1 (en) |
TW (1) | TW449597B (en) |
UA (1) | UA55391C2 (en) |
WO (1) | WO1997005136A1 (en) |
YU (1) | YU49479B (en) |
ZA (1) | ZA966494B (en) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19921693A1 (en) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Pharmaceutical composition for treating respiratory disorders, e.g. asthma, comprises combination of anticholinergic and beta-mimetic agents having synergistic bronchospasmolytic activity and reduced side-effects |
US20100197719A1 (en) * | 1999-05-12 | 2010-08-05 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
ES2165768B1 (en) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
US6777400B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6858593B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
US6750210B2 (en) | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
US6787532B2 (en) | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
US7776315B2 (en) * | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
US20020151541A1 (en) * | 2000-10-31 | 2002-10-17 | Michel Pairet | Pharmaceutical compositions containing tiotropium salts and antihistamines and their use |
US20100310477A1 (en) * | 2000-11-28 | 2010-12-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Pharmaceutical compositions based on anticholingerics and additional active ingredients |
UA77656C2 (en) | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
US6455028B1 (en) * | 2001-04-23 | 2002-09-24 | Pharmascience | Ipratropium formulation for pulmonary inhalation |
WO2002085296A2 (en) * | 2001-04-24 | 2002-10-31 | Epigenesis Pharmaceuticals, Inc. | Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent |
US20030018019A1 (en) * | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
US6702997B2 (en) | 2001-10-26 | 2004-03-09 | Dey, L.P. | Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma |
US20030140920A1 (en) * | 2001-10-26 | 2003-07-31 | Dey L.P. | Albuterol inhalation soultion, system, kit and method for relieving symptoms of pediatric asthma |
US20030203930A1 (en) * | 2001-10-26 | 2003-10-30 | Imtiaz Chaudry | Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease |
US20030191151A1 (en) * | 2001-10-26 | 2003-10-09 | Imtiaz Chaudry | Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease |
JP2003221335A (en) | 2001-10-26 | 2003-08-05 | Dey Lp | Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptom of chronic obstructive pulmonary disease |
GB0202635D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Wellcome Mfg Pte Ltd | Formulation containing novel anti-inflammatory androstane derivative |
GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
US20050043343A1 (en) * | 2003-07-28 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a PDE IV inhibitor |
US20050026948A1 (en) * | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a betamimetic |
US20090317476A1 (en) * | 2003-07-31 | 2009-12-24 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease |
US20050101545A1 (en) * | 2003-07-31 | 2005-05-12 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
US20050026882A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease |
US20050038004A1 (en) * | 2003-07-31 | 2005-02-17 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
ES2257152B1 (en) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | COMBINATIONS THAT INCLUDE ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS. |
PE20060826A1 (en) * | 2004-12-06 | 2006-10-08 | Smithkline Beecham Corp | OLEOPHINIC DERIVATIVE OF 8-AZONIABICICLO [3.2.1] OCTANE AND THE PHARMACEUTICAL COMBINATION THAT INCLUDES IT |
WO2006114379A1 (en) * | 2005-04-23 | 2006-11-02 | Boehringer Ingelheim International Gmbh | Combination of medicaments to be inhaled, containing a betamimetic agent and a steroid in addition to an anticholinergic agent |
US20060239935A1 (en) * | 2005-04-23 | 2006-10-26 | Boehringer Ingelheim International Gmbh | Compositions for inhalation |
EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
TW201311649A (en) * | 2011-09-05 | 2013-03-16 | Everlight Chem Ind Corp | Compounds for electrolyte of solar cell and methods of preparation thereof, electrolyte and solar cell having the same |
CN111751454B (en) * | 2019-03-29 | 2023-12-08 | 天津药业研究院股份有限公司 | Method for detecting content of ipratropium bromide intermediate I and related substances |
CN110361494B (en) * | 2019-06-26 | 2023-08-15 | 四川普锐特药业有限公司 | Method for detecting impurity G in ipratropium bromide aerosol |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3505337A (en) * | 1967-12-22 | 1970-04-07 | Boehringer Sohn Ingelheim | N - hydrocarbyl-substituted noratropinium,haloalkylates and o-acyl derivatives thereof |
DE2903957A1 (en) * | 1979-02-02 | 1980-08-07 | Boehringer Sohn Ingelheim | AGENT FOR TREATING NASAL HYPERSECRETION |
US5225183A (en) * | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
DE4140861C2 (en) * | 1991-12-11 | 2003-12-11 | Boehringer Ingelheim Kg | Process for the production of quaternary tropic acid alkaloids |
DK0673240T3 (en) * | 1992-12-09 | 1999-10-11 | Boehringer Ingelheim Pharma | Stabilized medical aerosol solution formulations |
-
1995
- 1995-08-01 DE DE19528145A patent/DE19528145A1/en not_active Withdrawn
-
1996
- 1996-07-10 TW TW085108367A patent/TW449597B/en not_active IP Right Cessation
- 1996-07-29 YU YU44596A patent/YU49479B/en unknown
- 1996-07-30 CZ CZ19962253A patent/CZ291998B6/en not_active IP Right Cessation
- 1996-07-31 RU RU98103895/04A patent/RU2171258C2/en active
- 1996-07-31 EE EE9800028A patent/EE04614B1/en unknown
- 1996-07-31 AU AU67397/96A patent/AU6739796A/en not_active Abandoned
- 1996-07-31 DK DK96927638T patent/DK0843676T3/en active
- 1996-07-31 SI SI9630405T patent/SI0843676T1/en unknown
- 1996-07-31 HU HU9602104A patent/HU228056B1/en unknown
- 1996-07-31 KR KR10-1998-0700661A patent/KR100445016B1/en not_active IP Right Cessation
- 1996-07-31 AT AT96927638T patent/ATE208390T1/en active
- 1996-07-31 RO RO98-00142A patent/RO120260B1/en unknown
- 1996-07-31 BR BR9609951A patent/BR9609951A/en not_active IP Right Cessation
- 1996-07-31 AR ARP960103824A patent/AR004179A1/en unknown
- 1996-07-31 CA CA002226934A patent/CA2226934C/en not_active Expired - Lifetime
- 1996-07-31 DE DE59608156T patent/DE59608156D1/en not_active Expired - Lifetime
- 1996-07-31 PL PL96324804A patent/PL183789B1/en unknown
- 1996-07-31 SK SK112-98A patent/SK283260B6/en not_active IP Right Cessation
- 1996-07-31 UA UA98021045A patent/UA55391C2/en unknown
- 1996-07-31 EP EP96927638A patent/EP0843676B1/en not_active Expired - Lifetime
- 1996-07-31 MX MX9800864A patent/MX9800864A/en unknown
- 1996-07-31 CO CO96040544A patent/CO4750836A1/en unknown
- 1996-07-31 IL IL11898696A patent/IL118986A/en not_active IP Right Cessation
- 1996-07-31 CN CN96195701A patent/CN1120841C/en not_active Expired - Lifetime
- 1996-07-31 ZA ZA966494A patent/ZA966494B/en unknown
- 1996-07-31 JP JP9507251A patent/JPH11510150A/en active Pending
- 1996-07-31 MY MYPI96003140A patent/MY115201A/en unknown
- 1996-07-31 PT PT96927638T patent/PT843676E/en unknown
- 1996-07-31 WO PCT/EP1996/003364 patent/WO1997005136A1/en active IP Right Grant
- 1996-07-31 TR TR1998/00121T patent/TR199800121T1/en unknown
- 1996-07-31 HR HR960365A patent/HRP960365B1/en not_active IP Right Cessation
- 1996-07-31 NZ NZ315645A patent/NZ315645A/en not_active IP Right Cessation
- 1996-07-31 ES ES96927638T patent/ES2167592T3/en not_active Expired - Lifetime
-
1998
- 1998-01-20 BG BG102202A patent/BG63780B1/en unknown
- 1998-01-30 NO NO19980424A patent/NO317561B1/en not_active IP Right Cessation
- 1998-10-21 HK HK98111418A patent/HK1013597A1/en not_active IP Right Cessation
- 1998-11-20 HK HK98112141A patent/HK1010879A1/en unknown
-
1999
- 1999-08-06 US US09/369,711 patent/US6299861B1/en not_active Expired - Lifetime
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