PE20060826A1 - OLEOPHINIC DERIVATIVE OF 8-AZONIABICICLO [3.2.1] OCTANE AND THE PHARMACEUTICAL COMBINATION THAT INCLUDES IT - Google Patents
OLEOPHINIC DERIVATIVE OF 8-AZONIABICICLO [3.2.1] OCTANE AND THE PHARMACEUTICAL COMBINATION THAT INCLUDES ITInfo
- Publication number
- PE20060826A1 PE20060826A1 PE2005001396A PE2005001396A PE20060826A1 PE 20060826 A1 PE20060826 A1 PE 20060826A1 PE 2005001396 A PE2005001396 A PE 2005001396A PE 2005001396 A PE2005001396 A PE 2005001396A PE 20060826 A1 PE20060826 A1 PE 20060826A1
- Authority
- PE
- Peru
- Prior art keywords
- octane
- pharmaceutical combination
- dry powder
- preferred
- powder inhaler
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UNA COMBINACION FARMACEUTICA QUE COMPRENDE UN ANTAGONISTA DEL RECEPTOR DE ACETILCOLINA MUSCARINICO TAL COMO: BROMURO DE (3-ENDO)-3-(2,2-DI-2-TIENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO Y UNO O MAS INGREDIENTES ACTIVOS TAL COMO i) UN AGONISTA ADRENORRECEPTOR ß-2 SIENDO PREFERIDO XINAFOATO DE SALMETEROL; Y ii) UN AGENTE CORTICOSTEROIDE ANTIINFALAMATORIO SIENDO PREFERIDO PROPIONATO DE FLUTICASONA. ESTA COMBINACION ES UTIL PARA EL TRATAMIENTO EN LA ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, BRONQUITIS CRONICA, ASMA, OBSTRUCCION RESPIRATORIA CRONICA, FIBROSIS PULMONAR, EFISEMA PULMONAR Y RINITIS ALERGICA. LA ADMINISTRACION SE REALIZA MEDIANTE UN DISPENSADOR SELECCIONADO DE UN INHALADOR DE POLVO SECO EN UN DEPOSITO, UN INHALADOR DE POLVO SECO EN MULTIPLES DOSIS O EN DOSIS MEDIDAS, CON UNA DURACION DE ACCION DE 12 HORAS A MAS, PARA UNA DOSIS DE 1 MGREFERS TO A PHARMACEUTICAL COMBINATION INCLUDING AN ANTAGONIST OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR SUCH AS: (3-ENDO) -3- (2,2-DI-2-THENYLETHENYL) -8,8-DIMETHYL-8-AZONIABICICLE BROMIDE [ 3.2.1] OCTANE AND ONE OR MORE ACTIVE INGREDIENTS SUCH AS i) A ß-2 ADRENORECEPTOR AGONIST, SALMETEROL XINAFOATE BEING PREFERRED; AND ii) AN ANTI-INFLAMMATORY CORTICOSTEROID AGENT, FLUTICASONE PROPIONATE BEING PREFERRED. THIS COMBINATION IS USEFUL FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, CHRONIC BRONCHITIS, ASTHMA, CHRONIC RESPIRATORY OBSTRUCTION, PULMONARY FIBROSIS, PULMONARY EPHYSEMA AND ALLERGIC RHINITIS. ADMINISTRATION IS CARRIED OUT THROUGH A SELECTED DISPENSER OF A DRY POWDER INHALER IN A TANK, A DRY POWDER INHALER IN MULTIPLE DOSES OR IN MEASURED DOSES, WITH AN ACTION DURATION OF 12 HOURS OR MORE, FOR A DOSE OF 1 MG
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63361804P | 2004-12-06 | 2004-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060826A1 true PE20060826A1 (en) | 2006-10-08 |
Family
ID=36578468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005001396A PE20060826A1 (en) | 2004-12-06 | 2005-12-01 | OLEOPHINIC DERIVATIVE OF 8-AZONIABICICLO [3.2.1] OCTANE AND THE PHARMACEUTICAL COMBINATION THAT INCLUDES IT |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR052145A1 (en) |
PE (1) | PE20060826A1 (en) |
TW (1) | TW200633715A (en) |
UY (1) | UY29245A1 (en) |
WO (1) | WO2006062931A2 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20050250A1 (en) | 2003-07-17 | 2005-04-08 | Glaxo Group Ltd | ANTAGONISTS OF ACETYLCHOLIN MUSCARINAL RECEPTORS |
ATE494285T1 (en) | 2003-10-14 | 2011-01-15 | Glaxo Group Ltd | MUSCARINE ACETYLCHOLINE RECEPTOR ANTAGONISTS |
AP2006003575A0 (en) | 2003-10-17 | 2006-04-30 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists. |
TW200524577A (en) | 2003-11-04 | 2005-08-01 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
EP1725564A4 (en) | 2004-03-17 | 2007-09-12 | Glaxo Group Ltd | M3 muscarinic acetylcholine receptor antagonists |
AR050902A1 (en) | 2004-04-27 | 2006-12-06 | Glaxo Group Ltd | QUINUCLIDINE COMPOSITE, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USOPRATION TO PREPARE SUCH COMPOSITION |
EP1747219A4 (en) | 2004-05-13 | 2010-05-26 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists field of the invention |
EP1957075A4 (en) | 2004-11-15 | 2009-11-18 | Glaxo Group Ltd | Novel m3 muscarinic acetylcholine receptor antagonists |
WO2007022351A2 (en) | 2005-08-18 | 2007-02-22 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
EP2080523A1 (en) * | 2008-01-15 | 2009-07-22 | CHIESI FARMACEUTICI S.p.A. | Compositions comprising an antimuscarinic and a long-acting beta-agonist |
TW200946526A (en) | 2008-02-06 | 2009-11-16 | Glaxo Group Ltd | Dual pharmacophores-PDE4-muscarinic antagonistics |
UY31636A1 (en) | 2008-02-06 | 2009-08-03 | DUE PHARMACOPHORES-MUSCARINIC ANTAGONISTS OF PDE4 | |
UY31637A1 (en) | 2008-02-06 | 2009-08-03 | DUE PHARMACOPHORES-MUSCARINIC ANTAGONISTS OF PDE4 | |
DK2400950T3 (en) | 2009-02-26 | 2019-07-29 | Glaxo Group Ltd | PHARMACEUTICAL FORMULA comprising 4 - {(1 R) -2 - [(6- {2 - [(2,6-DICHLORBENZYL) OXY] ETHOXY} HEXYL) AMINO] -1-HYDROXYETHYL} -2- (HYDROXYMETHYL) PHENOL |
GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
US20140113888A1 (en) * | 2011-06-08 | 2014-04-24 | Glaxo Group Limited | Novel Combination of Therapeutic Agents |
JP6267685B2 (en) | 2012-04-13 | 2018-01-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Aggregated particles |
GB201222679D0 (en) | 2012-12-17 | 2013-01-30 | Glaxo Group Ltd | Pharmaceutical combination products |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1140998B (en) * | 1980-06-18 | 1986-10-10 | Valeas Ind Chimica E Farmaceut | ENDO-8-METHYL-8-SIN-ALCHIL-8-AZONIABICYCLE OPEN SALTS PAR. SQUARE 3.2.1. CLOSED PAR. QUADRATA-OTTAN-3-ALCHILCARBOSSILATI, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS THAT CONTAIN THEM AS AN ACTIVE INGREDIENT |
IT1194343B (en) * | 1983-07-26 | 1988-09-14 | Valeas Spa | ENDO-8,8-DIALKYL-8-AZONIABICICLO SALTS (3.2.1) OTTAN-6,7-ESSO-EPOSSI-3-ALCHILCARBOSSILATI, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS THAT CONTAIN THEM AS AN ACTIVE INGREDIENT |
DE19528145A1 (en) * | 1995-08-01 | 1997-02-06 | Boehringer Ingelheim Kg | New drugs and their use |
US20030013675A1 (en) * | 2001-05-25 | 2003-01-16 | Boehringer Ingelheim Pharma Kg | Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases |
-
2005
- 2005-12-01 PE PE2005001396A patent/PE20060826A1/en not_active Application Discontinuation
- 2005-12-02 UY UY29245A patent/UY29245A1/en unknown
- 2005-12-05 TW TW094142714A patent/TW200633715A/en unknown
- 2005-12-05 AR ARP050105079A patent/AR052145A1/en unknown
- 2005-12-05 WO PCT/US2005/044033 patent/WO2006062931A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2006062931A3 (en) | 2007-04-19 |
UY29245A1 (en) | 2006-05-31 |
AR052145A1 (en) | 2007-03-07 |
TW200633715A (en) | 2006-10-01 |
WO2006062931A2 (en) | 2006-06-15 |
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