RU97122020A - 1,2,5-OXADIAZOLO [3,4-D] PYRIDAZIN-5,6-DIOXIDE DERIVATIVES AS ACTIVATORS OF THE SOLUBLE FORM OF GUANILALACYCLES AND FACILITIES FOR THE TREATMENT OF DISEASES OF CARDICOVASTRIVE SYSTEMSHEATH SYSTEMS Behavi-components, for the treatment of diseases of the cardiac vascular system, this means for the treatment of the diseases - Google Patents

1,2,5-OXADIAZOLO [3,4-D] PYRIDAZIN-5,6-DIOXIDE DERIVATIVES AS ACTIVATORS OF THE SOLUBLE FORM OF GUANILALACYCLES AND FACILITIES FOR THE TREATMENT OF DISEASES OF CARDICOVASTRIVE SYSTEMSHEATH SYSTEMS Behavi-components, for the treatment of diseases of the cardiac vascular system, this means for the treatment of the diseases

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Publication number
RU97122020A
RU97122020A RU97122020/14A RU97122020A RU97122020A RU 97122020 A RU97122020 A RU 97122020A RU 97122020/14 A RU97122020/14 A RU 97122020/14A RU 97122020 A RU97122020 A RU 97122020A RU 97122020 A RU97122020 A RU 97122020A
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RU
Russia
Prior art keywords
treatment
diseases
oxadiazolo
pyridazin
dioxide derivatives
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Application number
RU97122020/14A
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Russian (ru)
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RU2165256C2 (en
Inventor
А.Я. Коц
Ю.В. Хропов
М.А. Графов
А.С. Куликов
И.В. Овчинников
Н.Н. Белушкина
О.Г. Бусыгина
С.А. Гаврилова
Н.Н. Махова
Н.А. Медведева
Т.В. Буларгина
И.С. Северина
Original Assignee
Биологический факультет Московского государственного университета им.М.В.Ломоносова
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Priority to RU97122020/14A priority Critical patent/RU2165256C2/en
Priority claimed from RU97122020/14A external-priority patent/RU2165256C2/en
Publication of RU97122020A publication Critical patent/RU97122020A/en
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Publication of RU2165256C2 publication Critical patent/RU2165256C2/en

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Claims (5)

1. Применение производных 1,2,5-оксадиазоло[3,4-d]пиридазин-5,6-диоксида общей формулы I:
Figure 00000001

где R = CH3 или С6H5 и n = 0 или 1, в качестве средств для лечения заболеваний сердечно-сосудистой системы.1. The use of 1,2,5-oxadiazolo [3,4-d] pyridazine-5,6-dioxide derivatives of the general formula I:
Figure 00000001

where R = CH 3 or C 6 H 5 and n = 0 or 1, as agents for treating diseases of the cardiovascular system. 2. Применение производных 1,2,5-оксадиазоло[3,4-d]пиридазин-5,6-диоксида общей формулы I по п. 1, где R = СН3 и n = 0 или 1.2. The use of 1,2,5-oxadiazolo [3,4-d] pyridazine-5,6-dioxide derivatives of general formula I according to claim 1, where R = CH 3 and n = 0 or 1. 3. Применение производных 1,2,5-оксадиазоло[3,4-d]пиридазин-5,6-диоксида общей формулы I, где R = СН3 и n = 0 или 1, по п. 1 в качестве сосудорасширяющих, гипотензивных, спазмолитических, антиангинальных средств, вазодилятаторов, вазорелаксантов, ингибиторов агрегации тромбоцитов.3. The use of 1,2,5-oxadiazolo [3,4-d] pyridazine-5,6-dioxide derivatives of the general formula I, where R = CH 3 and n = 0 or 1, according to claim 1, as vasodilator, hypotensive , antispasmodic, antianginal drugs, vasodilators, vasorelaxants, inhibitors of platelet aggregation. 4. Применение соединения общей формулы I, где R = СН3 и n = 1 по п. 1 для профилактики и купирования приступов стенокардии и лечения острого инфаркта миокарда.4. The use of compounds of General formula I, where R = CH 3 and n = 1 under item 1 for the prevention and relief of strokes and the treatment of acute myocardial infarction. 5. Фармацевтические композиции, содержащие активный компонент и добавки, для лечения заболеваний сердечно-сосудистой системы, отличающиеся тем, что в качестве активного компонента используются производные 1,2,5-оксадиазоло[3,4-d] пиридазин-5,6-диоксида общей формулы I, где R = СН3 или С6Н5 и n = 0 или 1.5. Pharmaceutical compositions containing the active ingredient and additives for the treatment of diseases of the cardiovascular system, characterized in that derivatives of 1,2,5-oxadiazolo [3,4-d] pyridazin-5,6-dioxide are used as the active ingredient General formula I, where R = CH 3 or C 6 H 5 and n = 0 or 1.
RU97122020/14A 1997-12-26 1997-12-26 1,2,5-oxadiazolo[3,4-d]pyridazine-5,6-dioxide derivatives as activators of soluble form of guanylate-cyclase and agents active in treatment of central nervous system, and compositions based on these compounds RU2165256C2 (en)

Priority Applications (1)

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RU97122020/14A RU2165256C2 (en) 1997-12-26 1997-12-26 1,2,5-oxadiazolo[3,4-d]pyridazine-5,6-dioxide derivatives as activators of soluble form of guanylate-cyclase and agents active in treatment of central nervous system, and compositions based on these compounds

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Application Number Priority Date Filing Date Title
RU97122020/14A RU2165256C2 (en) 1997-12-26 1997-12-26 1,2,5-oxadiazolo[3,4-d]pyridazine-5,6-dioxide derivatives as activators of soluble form of guanylate-cyclase and agents active in treatment of central nervous system, and compositions based on these compounds

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RU97122020A true RU97122020A (en) 1999-09-27
RU2165256C2 RU2165256C2 (en) 2001-04-20

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