RU97104124A - 2,3-DIGIDRO-1- (2,2,2, -TRIFTOROETHYL) -2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINS - Google Patents
2,3-DIGIDRO-1- (2,2,2, -TRIFTOROETHYL) -2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINSInfo
- Publication number
- RU97104124A RU97104124A RU97104124/04A RU97104124A RU97104124A RU 97104124 A RU97104124 A RU 97104124A RU 97104124/04 A RU97104124/04 A RU 97104124/04A RU 97104124 A RU97104124 A RU 97104124A RU 97104124 A RU97104124 A RU 97104124A
- Authority
- RU
- Russia
- Prior art keywords
- phenyl
- oxo
- trifluoromethyl
- pharmaceutically acceptable
- compound according
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 206010003119 Arrhythmia Diseases 0.000 claims 2
- 206010007521 Cardiac arrhythmias Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003416 antiarrhythmic agent Substances 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 239000011630 iodine Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 230000000261 vasodilator Effects 0.000 claims 2
- 239000003071 vasodilator agent Substances 0.000 claims 2
- QSOSIOUXURONMT-UHFFFAOYSA-N 5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one Chemical class N=1CC(=O)N(CC(F)(F)F)C2=CC=CC=C2C=1C1=CC=CC=C1 QSOSIOUXURONMT-UHFFFAOYSA-N 0.000 claims 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Claims (1)
в которой Х и У представляют собой, независимо, водород, хлор, фтор, бром, иод или трифторметил;
n равно О, 1 или 2;
R представляет собой водород, фтор, хлор, бром, иод, или трифторметил, метил или метоксигруппу,
и смеси энантиомеров, отдельные диастереомеры или отдельные энантиомеры со всеми изомерными формами, и их фармацевтически приемлемые соли, гидраты или кристаллические формы.1. 2,3-dihydro-1- (2,2,2-trifluoroethyl) -2-oxo-5-phenyl-1H-1,4-benzodiazepines of general formula I:
in which X and Y represent, independently, hydrogen, chlorine, fluorine, bromine, iodine or trifluoromethyl;
n is 0, 1 or 2;
R represents hydrogen, fluorine, chlorine, bromine, iodine, or trifluoromethyl, methyl or methoxy,
and mixtures of enantiomers, individual diastereomers or individual enantiomers with all isomeric forms, and their pharmaceutically acceptable salts, hydrates or crystalline forms.
(-)-2-[2,4-бис(трифторметил)фенил] -N-[3R-2,3-дигидро-2-оксо-5-фенил-1-(2,2,2-трифторэтил)-1Н-бензо[е][1,4]диазепин-3-ил)-ацетиамид
3. Фармацевтическая композиция для лечения аритмии, содержащая фармацевтически приемлемый носитель и активный ингредиент, отличающаяся тем, что в качестве активного ингредиента содержит эффективное количество соединения по п. 1 или его фармацевтически приемлемой соли, кристаллической формы или гидрата.2. The compound according to claim 1, which represents
(-) - 2- [2,4-bis (trifluoromethyl) phenyl] -N- [3R-2,3-dihydro-2-oxo-5-phenyl-1- (2,2,2-trifluoroethyl) -1H benzo [e] [1,4] diazepin-3-yl) acetamide
3. Pharmaceutical composition for treating arrhythmias, containing a pharmaceutically acceptable carrier and active ingredient, characterized in that the active ingredient contains an effective amount of the compound according to claim 1 or a pharmaceutically acceptable salt, crystalline form or hydrate thereof.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29244794A | 1994-08-18 | 1994-08-18 | |
US292,447 | 1994-08-18 | ||
PCT/US1995/010500 WO1996005839A1 (en) | 1994-08-18 | 1995-08-17 | 2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines |
Publications (2)
Publication Number | Publication Date |
---|---|
RU97104124A true RU97104124A (en) | 1999-04-27 |
RU2149161C1 RU2149161C1 (en) | 2000-05-20 |
Family
ID=23124712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU97104124A RU2149161C1 (en) | 1994-08-18 | 1995-08-17 | 2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl -1h- 1,4-benzodiazepines and method of prevention or treatment or arythmia |
Country Status (24)
Country | Link |
---|---|
US (1) | US5658901A (en) |
EP (1) | EP0776208B1 (en) |
JP (1) | JPH10504570A (en) |
KR (1) | KR970705395A (en) |
CN (1) | CN1158568A (en) |
AT (1) | ATE186463T1 (en) |
AU (1) | AU692300B2 (en) |
BG (1) | BG63032B1 (en) |
BR (1) | BR9508608A (en) |
CA (1) | CA2195974C (en) |
CZ (1) | CZ285008B6 (en) |
DE (1) | DE69513295T2 (en) |
DK (1) | DK0776208T3 (en) |
ES (1) | ES2139933T3 (en) |
FI (1) | FI970668A0 (en) |
GR (1) | GR3032592T3 (en) |
HU (1) | HU220635B1 (en) |
MX (1) | MX9701195A (en) |
NO (1) | NO970731L (en) |
NZ (1) | NZ291988A (en) |
PL (1) | PL319104A1 (en) |
RU (1) | RU2149161C1 (en) |
SK (1) | SK282019B6 (en) |
WO (1) | WO1996005839A1 (en) |
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US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
AU6320998A (en) | 1997-02-21 | 1998-09-09 | Bristol-Myers Squibb Company | Benzoic acid derivatives and related compounds as antiarrhythmic agents |
US6048877A (en) * | 1997-02-21 | 2000-04-11 | Bristol-Myers Squibb Company | Tetralone derivatives as antiarrhythmic agents |
US6262068B1 (en) | 1997-02-21 | 2001-07-17 | Bristol-Myers Squibb Company | Lactam derivatives as antiarrhythmic agents |
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GB2328942A (en) * | 1997-09-05 | 1999-03-10 | Merck & Co Inc | Side chain synthesis for an antiarrythmic compound |
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ES2148057B1 (en) * | 1998-01-05 | 2001-05-16 | Univ Murcia | NEW USE OF DIACEPAM AS A POTENTIATOR OF THE EFFECT OF PDE 3 INHIBITORS |
US6664250B2 (en) | 1998-01-20 | 2003-12-16 | Bristol-Myers Squibb Co. | Lactam derivatives as antiarrhythmic agents |
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US20050192265A1 (en) * | 2003-03-20 | 2005-09-01 | Thompson Richard C. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
CU20090172A7 (en) | 2009-10-09 | 2011-10-05 | Ct De Investigación Y Desarrollo De Medicamentos | TRICYCLIC AND TETRACYCLIC SYSTEMS WITH ACTIVITY ON THE CENTRAL AND VASCULAR NERVOUS SYSTEM |
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-
1995
- 1995-08-17 CZ CZ97485A patent/CZ285008B6/en not_active IP Right Cessation
- 1995-08-17 CA CA002195974A patent/CA2195974C/en not_active Expired - Fee Related
- 1995-08-17 AT AT95930197T patent/ATE186463T1/en not_active IP Right Cessation
- 1995-08-17 HU HU9701275A patent/HU220635B1/en not_active IP Right Cessation
- 1995-08-17 DE DE69513295T patent/DE69513295T2/en not_active Expired - Fee Related
- 1995-08-17 WO PCT/US1995/010500 patent/WO1996005839A1/en not_active Application Discontinuation
- 1995-08-17 JP JP8508203A patent/JPH10504570A/en active Pending
- 1995-08-17 SK SK222-97A patent/SK282019B6/en unknown
- 1995-08-17 CN CN95195291A patent/CN1158568A/en active Pending
- 1995-08-17 AU AU33667/95A patent/AU692300B2/en not_active Ceased
- 1995-08-17 EP EP95930197A patent/EP0776208B1/en not_active Expired - Lifetime
- 1995-08-17 RU RU97104124A patent/RU2149161C1/en active
- 1995-08-17 BR BR9508608A patent/BR9508608A/en not_active Application Discontinuation
- 1995-08-17 ES ES95930197T patent/ES2139933T3/en not_active Expired - Lifetime
- 1995-08-17 PL PL95319104A patent/PL319104A1/en unknown
- 1995-08-17 NZ NZ291988A patent/NZ291988A/en unknown
- 1995-08-17 US US08/516,226 patent/US5658901A/en not_active Expired - Fee Related
- 1995-08-17 DK DK95930197T patent/DK0776208T3/en active
- 1995-08-17 KR KR1019970701009A patent/KR970705395A/en not_active Application Discontinuation
- 1995-08-17 MX MX9701195A patent/MX9701195A/en unknown
-
1997
- 1997-02-12 BG BG101227A patent/BG63032B1/en unknown
- 1997-02-17 NO NO970731A patent/NO970731L/en not_active Application Discontinuation
- 1997-02-17 FI FI970668A patent/FI970668A0/en unknown
-
2000
- 2000-02-04 GR GR20000400287T patent/GR3032592T3/en not_active IP Right Cessation
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