RU97104124A - 2,3-DIGIDRO-1- (2,2,2, -TRIFTOROETHYL) -2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINS - Google Patents

2,3-DIGIDRO-1- (2,2,2, -TRIFTOROETHYL) -2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINS

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Publication number
RU97104124A
RU97104124A RU97104124/04A RU97104124A RU97104124A RU 97104124 A RU97104124 A RU 97104124A RU 97104124/04 A RU97104124/04 A RU 97104124/04A RU 97104124 A RU97104124 A RU 97104124A RU 97104124 A RU97104124 A RU 97104124A
Authority
RU
Russia
Prior art keywords
phenyl
oxo
trifluoromethyl
pharmaceutically acceptable
compound according
Prior art date
Application number
RU97104124/04A
Other languages
Russian (ru)
Other versions
RU2149161C1 (en
Inventor
А.Клэремон Дэвид
Ливертон Найджел
Дж.Селник Гарольд
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Priority claimed from PCT/US1995/010500 external-priority patent/WO1996005839A1/en
Publication of RU97104124A publication Critical patent/RU97104124A/en
Application granted granted Critical
Publication of RU2149161C1 publication Critical patent/RU2149161C1/en

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Claims (1)

1. 2,3-дигидро-1-(2,2,2-трифторэтил)-2-оксо-5-фенил-1Н-1,4-бензодиазепины, общей формулы I:
Figure 00000001

в которой Х и У представляют собой, независимо, водород, хлор, фтор, бром, иод или трифторметил;
n равно О, 1 или 2;
R представляет собой водород, фтор, хлор, бром, иод, или трифторметил, метил или метоксигруппу,
и смеси энантиомеров, отдельные диастереомеры или отдельные энантиомеры со всеми изомерными формами, и их фармацевтически приемлемые соли, гидраты или кристаллические формы.1. 2,3-dihydro-1- (2,2,2-trifluoroethyl) -2-oxo-5-phenyl-1H-1,4-benzodiazepines of general formula I:
Figure 00000001

in which X and Y represent, independently, hydrogen, chlorine, fluorine, bromine, iodine or trifluoromethyl;
n is 0, 1 or 2;
R represents hydrogen, fluorine, chlorine, bromine, iodine, or trifluoromethyl, methyl or methoxy,
and mixtures of enantiomers, individual diastereomers or individual enantiomers with all isomeric forms, and their pharmaceutically acceptable salts, hydrates or crystalline forms. 2. Соединение по п. 1, представляющее собой
(-)-2-[2,4-бис(трифторметил)фенил] -N-[3R-2,3-дигидро-2-оксо-5-фенил-1-(2,2,2-трифторэтил)-1Н-бензо[е][1,4]диазепин-3-ил)-ацетиамид
Figure 00000002

3. Фармацевтическая композиция для лечения аритмии, содержащая фармацевтически приемлемый носитель и активный ингредиент, отличающаяся тем, что в качестве активного ингредиента содержит эффективное количество соединения по п. 1 или его фармацевтически приемлемой соли, кристаллической формы или гидрата.2. The compound according to claim 1, which represents
(-) - 2- [2,4-bis (trifluoromethyl) phenyl] -N- [3R-2,3-dihydro-2-oxo-5-phenyl-1- (2,2,2-trifluoroethyl) -1H benzo [e] [1,4] diazepin-3-yl) acetamide
Figure 00000002

3. Pharmaceutical composition for treating arrhythmias, containing a pharmaceutically acceptable carrier and active ingredient, characterized in that the active ingredient contains an effective amount of the compound according to claim 1 or a pharmaceutically acceptable salt, crystalline form or hydrate thereof. 4. Фармацевтическая композиция по п. 3, отличающаяся тем, что дополнительно содержит еще другое антиаритмическое средство или другое сосудорасширяющее средство. 4. The pharmaceutical composition according to p. 3, characterized in that it additionally contains another antiarrhythmic agent or another vasodilator. 5. Способ предупреждения или лечения аритмии, отличающийся тем, что вводят пациенту, нуждающемуся в таком лечении, антиаритмически эффективное количество соединения по п. 1. 5. A method of preventing or treating arrhythmias, characterized in that the antiarrhythmically effective amount of the compound according to claim 1 is administered to a patient in need of such treatment. 6. Способ по п. 5, отличающийся тем, что осуществляют сопутствующее введение еще другого антиаритмического средства или другого сосудорасширяющего средства. 6. The method according to p. 5, characterized in that carry out the concomitant administration of another antiarrhythmic agent or another vasodilator.
RU97104124A 1994-08-18 1995-08-17 2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl -1h- 1,4-benzodiazepines and method of prevention or treatment or arythmia RU2149161C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US292,447 1988-12-30
US29244794A 1994-08-18 1994-08-18
PCT/US1995/010500 WO1996005839A1 (en) 1994-08-18 1995-08-17 2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines

Publications (2)

Publication Number Publication Date
RU97104124A true RU97104124A (en) 1999-04-27
RU2149161C1 RU2149161C1 (en) 2000-05-20

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Country Status (24)

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US (1) US5658901A (en)
EP (1) EP0776208B1 (en)
JP (1) JPH10504570A (en)
KR (1) KR970705395A (en)
CN (1) CN1158568A (en)
AT (1) ATE186463T1 (en)
AU (1) AU692300B2 (en)
BG (1) BG63032B1 (en)
BR (1) BR9508608A (en)
CA (1) CA2195974C (en)
CZ (1) CZ285008B6 (en)
DE (1) DE69513295T2 (en)
DK (1) DK0776208T3 (en)
ES (1) ES2139933T3 (en)
FI (1) FI970668A0 (en)
GR (1) GR3032592T3 (en)
HU (1) HU220635B1 (en)
MX (1) MX9701195A (en)
NO (1) NO970731L (en)
NZ (1) NZ291988A (en)
PL (1) PL319104A1 (en)
RU (1) RU2149161C1 (en)
SK (1) SK282019B6 (en)
WO (1) WO1996005839A1 (en)

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