RU96124807A - METHOD FOR REMOVAL OF HUMAN ACIDS SALTS FROM HUMAN ORGANISM AND ALKYLED COMPOSITIONS FOR THIS METHOD - Google Patents

METHOD FOR REMOVAL OF HUMAN ACIDS SALTS FROM HUMAN ORGANISM AND ALKYLED COMPOSITIONS FOR THIS METHOD

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RU96124807A
RU96124807A RU96124807/04A RU96124807A RU96124807A RU 96124807 A RU96124807 A RU 96124807A RU 96124807/04 A RU96124807/04 A RU 96124807/04A RU 96124807 A RU96124807 A RU 96124807A RU 96124807 A RU96124807 A RU 96124807A
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Prior art keywords
alkylating agent
interact
nitrogen atoms
structural units
cross
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RU96124807/04A
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Russian (ru)
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RU2160742C2 (en
Inventor
В Харри Мэндевилл III
Стефен Рэндалл Хольмс-Фарли
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Джелтекс Фармасьютикэлс, Инк.
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1. Способ выведения желчных камней из организма человека, включающий использование смолы, отличающийся тем, что в качестве ионообменной смолы используют реакционный продукт, содержащий один или несколько поперечносшитых полимеров, включающих повторяющиеся структурное звено, выбранное из группы, состоящей из
Figure 00000001

Figure 00000002

(NR2-CH2CH2)n (3)
(NR - CH2CH2 - NR - CH2CH2 - NR - CH2CHOH - CH2)n, (4)
и соли и сополимеры на их основе, где n - целое число и каждый радикал R, независимо, - это H, или C1 - C8 алкильная группа, и по меньшей мере один алкилирующий агент, при этом некоторые из атомов в структурных звеньях полимера не взаимодействуют с алкилирующим агентом и менее 10 моль% атомов азота в структурных звеньях, взаимодействующих с алкилирующим агентом, образуют соединения четвертичного аммония.1. The method of removing gallstones from the human body, including the use of resin, characterized in that as the ion-exchange resin using a reaction product containing one or more cross-linked polymers, including a repeating structural unit selected from the group consisting of
Figure 00000001

Figure 00000002

(NR 2 -CH 2 CH 2 ) n (3)
(NR - CH 2 CH 2 - NR - CH 2 CH 2 - NR - CH 2 CHOH - CH 2 ) n , (4)
and salts and copolymers based on them, where n is an integer and each radical R, independently, is H, or a C 1 - C 8 alkyl group, and at least one alkylating agent, with some of the atoms in the structural units of the polymer do not interact with the alkylating agent and less than 10 mol% of nitrogen atoms in the structural units that interact with the alkylating agent form quaternary ammonium compounds. 2. Способ по п.1, отличающийся тем, что используют полимер, взаимодействующий по меньшей мере с двумя алкилирующими агентами, причем один из агентов имеет формулу RX, где R является C1 - C20 алкильной группой и X - одна или несколько электрофильных групп, а другой алкилирующий агент имеет формулу R*X, где R* является C1 - C20 алкил аммониевой группой и X - одна или несколько электрофильных групп.2. The method according to p. 1, characterized in that use a polymer that interacts with at least two alkylating agents, and one of the agents has the formula RX, where R is a C 1 - C 20 alkyl group and X is one or more electrophilic groups and the other alkylating agent has the formula R * X, where R * is a C 1 - C 20 alkyl ammonium group and X is one or more electrophilic groups. 3. Способ выведения желчных камней из организма человека, включающий использование ионообсенной смолы, отличающийся тем, что в качестве ионнообменной смолы используют продукт, содержащий один или несколько поперечносшитых полимеров, включающих повторяющееся структурное звено, имеющее формулу
Figure 00000003

и соли и сополимеры на их основе, где n - целое число и каждый радикал R, независимо, - это H, или C1 - C8 алкильная группа; и по меньшей мере один алкилирующий агент, при этом некоторые из атомов азота в структурных звеньях полимера не взаимодействуют с алкилирующим агентом и менее 10 моль% атомов азота в структурных звеньях, взаимодействующих с алкилирующим агентом, образуют соединения четвертичного аммония.3. The method of removing gallstones from the human body, including the use of ion-excreted resin, characterized in that as the ion exchange resin use a product containing one or more cross-linked polymers, including a repeating structural unit having the formula
Figure 00000003

and salts and copolymers based on them, where n is an integer and each radical R, independently, is H, or a C 1 -C 8 alkyl group; and at least one alkylating agent, while some of the nitrogen atoms in the structural units of the polymer do not interact with the alkylating agent and less than 10 mol% of the nitrogen atoms in the structural units interacting with the alkylating agent form quaternary ammonium compounds. 4. Алкиллированный поперечносшитый полимер, включающий реакционный продукт, состоящий из одного или нескольких поперечносшитых полимеров, содержащих повторяющееся структурное звено, выбранное из группы:
Figure 00000004

Figure 00000005

(NR2 - CH2 CH2)n (3)
(NR - CH2CH2 - NR - CH2CH2 - NR - CH2CHOH - CH2)n (4)
и соли и сополимеры на их основе, где n - целое число и каждый радикал R, независимо, это H, или C1 - C8 алкильная группа; и по меньшей мере одного алкилирующего агента, при этом реакционный продукт характеризуется тем, что по меньшей мере некоторые из атомов азота в структурных звеньях не взаимодействуют с алкилирующим агентом и менее 10 моль% атомов азота в структурных звеньях взаимодействуют с алкилирующим агентом, образуя соединения четвертичного аммония.4. Alkylated cross-linked polymer comprising a reaction product consisting of one or more cross-linked polymers containing a repeating structural unit selected from the group:
Figure 00000004

Figure 00000005

(NR 2 - CH 2 CH 2 ) n (3)
(NR - CH 2 CH 2 - NR - CH 2 CH 2 - NR - CH 2 CHOH - CH 2 ) n (4)
and salts and copolymers based on them, where n is an integer and each radical R, independently, is H, or a C 1 -C 8 alkyl group; and at least one alkylating agent, while the reaction product is characterized by the fact that at least some of the nitrogen atoms in the structural units do not interact with the alkylating agent and less than 10 mol% of the nitrogen atoms in the structural units interact with the alkylating agent to form quaternary ammonium compounds . 5. Алкилированный поперечносшитый полимер, включающий реакционный продукт, состоящий из одного или нескольких поперечносшитых полимеров, содержащих повторяющееся структурное звено, имеющее формулу
Figure 00000006

и соли и сополимеры на их основе, где n - целое число и каждый радикал R, независимо, это H, или C1 - C8 алкильная группа; и по меньшей мере одного алкилирующего агента, при этом реакционный продукт характеризуется тем, что по меньшей мере некоторые из атомов азота в звеньях не взаимодействуют с алкилирующим агентом и менее 10 моль% атомов азота в структурных звеньях взаимодействуют с алкилирующим агентом, образуя соединения четвертичного аммония.5. An alkylated cross-linked polymer comprising a reaction product consisting of one or more cross-linked polymers containing a repeating structural unit having the formula
Figure 00000006

and salts and copolymers based on them, where n is an integer and each radical R, independently, is H, or a C 1 -C 8 alkyl group; and at least one alkylating agent, wherein the reaction product is characterized by the fact that at least some of the nitrogen atoms in the units do not interact with the alkylating agent and less than 10 mol% of the nitrogen atoms in the structural units interact with the alkylating agent, forming quaternary ammonium compounds.
RU96124807/04A 1994-06-10 1995-06-05 Method of withdrawing gall-stones from patent's body (variants) and alkylated cross-linked polymer for carrying in through RU2160742C2 (en)

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US25843194A 1994-06-10 1994-06-10
US08/258.431 1994-06-10
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