RU94002329A - MODIFIED OLYHODESOXYRIBONUCLEOTIDE, COMPOSITION, TREATMENT METHOD AND INTERMEDIATE CONNECTIONS - Google Patents

MODIFIED OLYHODESOXYRIBONUCLEOTIDE, COMPOSITION, TREATMENT METHOD AND INTERMEDIATE CONNECTIONS

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Publication number
RU94002329A
RU94002329A RU94002329/04A RU94002329A RU94002329A RU 94002329 A RU94002329 A RU 94002329A RU 94002329/04 A RU94002329/04 A RU 94002329/04A RU 94002329 A RU94002329 A RU 94002329A RU 94002329 A RU94002329 A RU 94002329A
Authority
RU
Russia
Prior art keywords
compounds
description
represent
group
olyhodesoxyribonucleotide
Prior art date
Application number
RU94002329/04A
Other languages
Russian (ru)
Other versions
RU2111971C1 (en
Inventor
Фурукава Хидехико
Момота Кендзи
Хотода Хитоси
Койзуми Макото
Канеко Масакацу
Original Assignee
Санкио Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санкио Компани Лимитед filed Critical Санкио Компани Лимитед
Publication of RU94002329A publication Critical patent/RU94002329A/en
Application granted granted Critical
Publication of RU2111971C1 publication Critical patent/RU2111971C1/en

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Claims (1)

Предлагаемые соединения используются для лечения или профилактики вирусных инфекций у млекопитающих, к которым относятся и люди. Соединения представляют собой производные олигодезоксирибонуклеиновой кислоты. Предлагается также новый способ получения таких соединений, а также промежуточные соединения, которые могут найти более общую область использования. Активные соединения являются соединениями общей формулы (I):
Figure 00000001

в которой R1, R2 и R3 представляют атомы водорода, алкильные группы, арильные группы, определенные в описании, и антрахинонильные группы, определенные в описании; Z представляет углерод или кремний; или R2, R3 и Z вместе представляют флуоренил или ксантенил; R4 представляет атом водорода, алкильную группу, как она определена в описании, арильную группу, определена в описании, Y1, Y3 и Y4 представляют кислород, серу или группу > NH; Y2 представляет кислород, серу, > NH, алкилен или фенилен, X - алкиленовая группа, как она определена в описании; m и n представляют 0 - 10 и В- олигодезоксирибонуклеотид цепи длиной 3 - 9, или их солями.The proposed compounds are used for the treatment or prevention of viral infections in mammals, which include humans. The compounds are oligodeoxyribonucleic acid derivatives. A new method for producing such compounds is also proposed, as well as intermediate compounds that may find a more general field of use. The active compounds are compounds of the general formula (I):
Figure 00000001

in which R 1 , R 2 and R 3 represent hydrogen atoms, alkyl groups, aryl groups, as defined in the description, and anthraquinonyl groups, as defined in the description; Z is carbon or silicon; or R 2 , R 3 and Z together represent fluorenyl or xantenyl; R 4 represents a hydrogen atom, an alkyl group as defined in the description, an aryl group as defined in the description, Y 1 , Y 3 and Y 4 represent oxygen, sulfur or the group>NH; Y 2 is oxygen, sulfur,> NH, alkylene or phenylene, X is an alkylene group as defined in the description; m and n represent 0-10 and B-oligodeoxyribonucleotide chains of length 3-9, or their salts.
RU94002329A 1993-01-29 1994-01-28 Modified oligodeoxyribonucleotides, composition based on thereof and intermediate compounds RU2111971C1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP5-13509 1993-01-29
JP1350993 1993-01-29
JP13557393 1993-06-07
JP5-135573 1993-06-07
JP5-138517 1993-06-10
JP13851793 1993-06-10

Publications (2)

Publication Number Publication Date
RU94002329A true RU94002329A (en) 1995-09-10
RU2111971C1 RU2111971C1 (en) 1998-05-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU94002329A RU2111971C1 (en) 1993-01-29 1994-01-28 Modified oligodeoxyribonucleotides, composition based on thereof and intermediate compounds

Country Status (19)

Country Link
US (2) US5674856A (en)
EP (1) EP0611075B1 (en)
KR (1) KR100318796B1 (en)
CN (2) CN1039014C (en)
AT (1) ATE146479T1 (en)
AU (1) AU670154B2 (en)
CA (1) CA2114355A1 (en)
CZ (1) CZ287050B6 (en)
DE (1) DE69401136T2 (en)
DK (1) DK0611075T3 (en)
ES (1) ES2098866T3 (en)
FI (1) FI111265B (en)
GR (1) GR3022821T3 (en)
HK (2) HK1000191A1 (en)
HU (1) HU222834B1 (en)
IL (1) IL108467A (en)
NO (1) NO309427B1 (en)
NZ (2) NZ250795A (en)
RU (1) RU2111971C1 (en)

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US6291438B1 (en) 1993-02-24 2001-09-18 Jui H. Wang Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
CN1060177C (en) * 1997-06-28 2001-01-03 中国科学院上海生物化学研究所 3'-monophosphorylated oligonucleotides
GB9823646D0 (en) * 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
US6995259B1 (en) * 1998-10-23 2006-02-07 Sirna Therapeutics, Inc. Method for the chemical synthesis of oligonucleotides
DE10041809A1 (en) * 2000-08-25 2002-03-07 Giesing Michael Arrays of immobilized biomolecules, their manufacture and use
US7205399B1 (en) 2001-07-06 2007-04-17 Sirna Therapeutics, Inc. Methods and reagents for oligonucleotide synthesis
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US20070065877A1 (en) * 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
JP5721180B2 (en) * 2009-12-08 2015-05-20 国立大学法人岐阜大学 Aromatic compound, modified carrier for synthesis of oligonucleotide derivative using the same, oligonucleotide derivative and oligonucleotide construct
CN102766183B (en) * 2011-05-05 2016-09-14 中国人民解放军军事医学科学院毒物药物研究所 There is the nucleic acid structure of the modification of anti-HIV-1 fusion activity
CN116496335B (en) * 2023-03-21 2024-03-08 中国药科大学 Modified nucleotide and application thereof

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JP3061659B2 (en) * 1991-08-01 2000-07-10 ヤマサ醤油株式会社 2- {2- (monomethoxytrityloxy) ethylthio} ethyl group and use of said group
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
NZ245720A (en) * 1992-01-22 1995-12-21 Hoechst Ag Oligonucleotide analogues; use as gene expression inhibitor or dna probe
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
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