RU96115328A - METHOD FOR PRODUCING CREATINE OR CREATINE MONOHYDRATE - Google Patents

METHOD FOR PRODUCING CREATINE OR CREATINE MONOHYDRATE

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Publication number
RU96115328A
RU96115328A RU96115328/04A RU96115328A RU96115328A RU 96115328 A RU96115328 A RU 96115328A RU 96115328/04 A RU96115328/04 A RU 96115328/04A RU 96115328 A RU96115328 A RU 96115328A RU 96115328 A RU96115328 A RU 96115328A
Authority
RU
Russia
Prior art keywords
paragraphs
creatine
cyanamide
sodium
water
Prior art date
Application number
RU96115328/04A
Other languages
Russian (ru)
Other versions
RU2163233C2 (en
Inventor
Вайсс Штефан
Кроммер Хельмут
Original Assignee
СКВ Тростберг АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19526236A external-priority patent/DE19526236A1/en
Application filed by СКВ Тростберг АГ filed Critical СКВ Тростберг АГ
Publication of RU96115328A publication Critical patent/RU96115328A/en
Application granted granted Critical
Publication of RU2163233C2 publication Critical patent/RU2163233C2/en

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Claims (14)

1. Способ получения креатина или моногидрата креатина, отличающийся тем, что цианамид вводят во взаимодействие с саркозинатом натрия или калия в воде или в смеси из воды и органического растворителя при температуре от 20 до 150oC и значении pH от 7,0 до 14,0.1. The method of producing creatine or creatine monohydrate, characterized in that the cyanamide is introduced into interaction with sodium or potassium sarcosinate in water or in a mixture of water and an organic solvent at a temperature of from 20 to 150 o C and a pH value of from 7.0 to 14, 0. 2. Способ по п. 1, отличающийся тем, что взаимодействие проводят при температуре от 50 до 100oC.2. The method according to p. 1, characterized in that the interaction is carried out at a temperature of from 50 to 100 o C. 3. Способ по п. 1 или 2, отличающийся тем, что значение pH устанавливают равным 9,0 - 10,0. 3. The method according to p. 1 or 2, characterized in that the pH value is set equal to 9.0 to 10.0. 4. Способ по одному из пп. 1 - 3, отличающийся тем, что значение pH устанавливают с помощью неорганической кислоты, предпочтительно с помощью соляной кислоты. 4. The method according to one of paragraphs. 1 to 3, characterized in that the pH value is set with an inorganic acid, preferably with hydrochloric acid. 5. Способ по одному из пп. 1 - 3, отличающийся тем, что для установления значения pH используют органическую кислоту, предпочтительно саркозин, уксусную кислоту или муравьиную кислоту. 5. The method according to one of paragraphs. 1-3, characterized in that an organic acid, preferably sarcosine, acetic acid or formic acid is used to establish the pH value. 6. Способ по одному из пп. 1 - 5, отличающийся тем, что мольное соотношение между цианамидом и саркозинатом натрия или калия устанавливают равным 1:4 - 4:1. 6. The method according to one of paragraphs. 1 to 5, characterized in that the molar ratio between cyanamide and sodium or potassium sarcosinate is set to 1: 4 to 4: 1. 7. Способ по п. 6, отличающийся тем, что мольное соотношение между цианамидом и саркозинатом натрия или калия составляет 0,9:1 - 1,25:1. 7. The method according to p. 6, characterized in that the molar ratio between cyanamide and sodium or potassium sarcosinate is 0.9: 1 to 1.25: 1. 8. Способ по одному из пп. 1 - 7, отличающийся тем, что саркозинат натрия или калия используют в форме 35 - 45 вес.м%-ного водного раствора. 8. The method according to one of paragraphs. 1 to 7, characterized in that the sodium or potassium sarcosinate is used in the form of a 35 to 45 wt.% Aqueous solution. 9. Способ по одному из пп. 1 - 8, отличающийся тем, что используют цианамид в форме водного раствора, в частности, в виде 50 вес.м%-ного раствора. 9. The method according to one of paragraphs. 1 to 8, characterized in that the use of cyanamide in the form of an aqueous solution, in particular in the form of a 50 wt.% Solution. 10. Способ по одному из пп. 1 - 9, отличающийся тем, что в качестве органического растворителя применяют алифатический спирт с 1 - 5 атомами C. 10. The method according to one of paragraphs. 1 to 9, characterized in that an aliphatic alcohol with 1 to 5 C atoms is used as an organic solvent. 11. Способ по одному из пп. 1 - 10, отличающийся тем, что реакционный продукт с целью очистки обрабатывают холодной или горячей водой. 11. The method according to one of paragraphs. 1 to 10, characterized in that the reaction product is treated with cold or hot water for the purpose of purification. 12. Способ по одному из пп. 1 - 11, отличающийся тем, что реакционный продукт перекристаллизовывают из воды. 12. The method according to one of paragraphs. 1 to 11, characterized in that the reaction product is recrystallized from water. 13. Способ по одному из пп. 1 - 12, отличающийся тем, что для получения обезвоженного креатина реакционный продукт высушивают до содержания < 1 вес. м%. 13. The method according to one of paragraphs. 1 to 12, characterized in that in order to obtain dehydrated creatine, the reaction product is dried to a content of <1 weight. m%. 14. Способ по одному из пп. 1 - 12, отличающийся тем, что для получения моногидрата креатина реакционный продукт высушивают до содержания воды, равного приблизительно 12,1 вес.%. 14. The method according to one of paragraphs. 1 to 12, characterized in that to obtain creatine monohydrate, the reaction product is dried to a water content of approximately 12.1 wt.%.
RU96115328/04A 1995-07-18 1996-07-17 Method of preparing creatine or creatine monohydrate RU2163233C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19526236.0 1995-07-18
DE19526236A DE19526236A1 (en) 1995-07-18 1995-07-18 Process for the production of creatine or creatine monohydrate

Publications (2)

Publication Number Publication Date
RU96115328A true RU96115328A (en) 1998-10-20
RU2163233C2 RU2163233C2 (en) 2001-02-20

Family

ID=7767164

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96115328/04A RU2163233C2 (en) 1995-07-18 1996-07-17 Method of preparing creatine or creatine monohydrate

Country Status (16)

Country Link
US (1) US5719319A (en)
EP (1) EP0754679B1 (en)
JP (1) JP3056416B2 (en)
CN (1) CN1061647C (en)
AT (1) ATE172715T1 (en)
CA (1) CA2181026C (en)
CZ (1) CZ290563B6 (en)
DE (2) DE19526236A1 (en)
DK (1) DK0754679T3 (en)
ES (1) ES2126355T3 (en)
HU (1) HU218820B (en)
NO (1) NO305200B1 (en)
PL (1) PL184404B1 (en)
RU (1) RU2163233C2 (en)
SI (1) SI0754679T1 (en)
SK (1) SK280544B6 (en)

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WO1998053704A1 (en) * 1997-05-30 1998-12-03 Kellogg Company Creatine containing cereal-based food product, processes for making these, and uses thereof
US6465018B1 (en) * 1997-08-22 2002-10-15 B. David Tuttle Dietary supplement for increasing energy, strength, and immune function
DE19748695A1 (en) * 1997-11-04 1999-05-06 Basf Ag Process for the preparation of substituted guanidine derivatives
DE19748697A1 (en) * 1997-11-04 1999-05-06 Basf Ag Process for the preparation of substituted guanidine derivatives
DE19748696A1 (en) * 1997-11-04 1999-05-06 Basf Ag Process for the preparation of substituted guanidine derivatives
DE19748694A1 (en) * 1997-11-04 1999-05-06 Basf Ag Process for the preparation of substituted guanidine derivatives
CN1097578C (en) * 1998-06-19 2003-01-01 李森 Production process of high-purity creatine and its monohydrate
DE19841525A1 (en) * 1998-09-10 2000-03-16 Basf Ag Process for the preparation of creatine or creatine monohydrate
DE19860048A1 (en) * 1998-12-23 2000-06-29 Basf Ag Process for the production of guanidine derivatives
DE19905711A1 (en) * 1999-02-11 2000-08-17 Basf Ag Process for the preparation of guanidine derivatives
CN1098251C (en) * 1999-09-07 2003-01-08 天津天成制药有限公司 Method of preparing creatine or its hydrate
DE19962227A1 (en) * 1999-12-22 2001-06-28 Basf Ag Process for the purification of creatine
WO2004031133A1 (en) * 2002-10-04 2004-04-15 Flexsys B.V. Process for the synthesis of guanidine derivatives
DE10331481A1 (en) * 2003-07-11 2005-02-24 Degussa Ag Process for reducing formaldehyde and cyanide levels in solutions of sarcosine salts
DE102006016227A1 (en) * 2006-04-06 2007-10-11 Degussa Gmbh Process for the preparation of creatine, creatine monohydrate or guanidinoacetic acid
CN101434563B (en) * 2008-12-15 2011-06-22 太仓市新毛涤纶化工有限公司 Preparation of creatine monohydrate
CN102329249A (en) * 2011-07-22 2012-01-25 周彬 Method for chemically synthesizing guanidinopropionic acid
JP6055777B2 (en) * 2011-11-10 2016-12-27 広久 西澤 Method for producing aqueous creatine composition solution
WO2014121648A1 (en) * 2013-02-05 2014-08-14 江苏远洋药业股份有限公司 Synthesis method for creatine
CN104086461B (en) * 2014-07-07 2016-02-24 上海宝穗化工有限公司 The preparation method of creatine monohydrate
CN107721882A (en) * 2016-08-11 2018-02-23 宁夏天成生化科技有限公司 Preparation method of N-methyl guanidino propionic acid
CN106831495A (en) * 2016-12-28 2017-06-13 安徽省虹升生物股份有限公司 A kind of chemical industry synthesis method of creatine monohydrate
CN110596269B (en) * 2019-09-20 2022-03-04 汤臣倍健股份有限公司 Content determination method for simultaneously detecting multiple components in creatine powder
CN115322122A (en) * 2022-09-14 2022-11-11 宁夏太康药业有限公司 Method for preparing creatine monohydrate from creatine chelated calcium aqueous solution
CN116041226B (en) * 2022-12-16 2024-06-11 山东阳谷华泰化工股份有限公司 Method for continuously synthesizing creatine monohydrate
EP4455123A1 (en) * 2023-09-20 2024-10-30 Qiangjiang Yongan Pharmaceutical Co., Ltd. Novel preparation method for sarcosine and derivatives thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE494918C (en) * 1926-10-29 1930-03-31 Schering Kahlbaum Akt Ges Process for the preparation of guanidines
US1967400A (en) * 1930-03-27 1934-07-24 Schering Kahlbaum Ag Production of guanidino fatty acids
US2654779A (en) * 1950-12-23 1953-10-06 Int Minerals & Chem Corp Method of preparation of guanidino fatty acids
US2620354A (en) * 1951-01-12 1952-12-02 Int Minerals & Chem Corp Production of guanidino fatty acids
CH401989A (en) * 1958-09-26 1965-11-15 Kuhlmann Ets Process for preparing phosphocreatine
FR1210435A (en) * 1958-09-26 1960-03-08 Cfmc Process for the synthesis of phosphocreatine
JPS59500B2 (en) * 1978-06-28 1984-01-07 富郎 岩井 Creatine manufacturing method

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