RU96115134A - Compound 6- (2-IMIDAZOLINILAMINO) QUINOLINA, SUITABLE AS AN AGONISTS OF ALPHA-2-ADRENOCEPTORS - Google Patents

Compound 6- (2-IMIDAZOLINILAMINO) QUINOLINA, SUITABLE AS AN AGONISTS OF ALPHA-2-ADRENOCEPTORS

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Publication number
RU96115134A
RU96115134A RU96115134/04A RU96115134A RU96115134A RU 96115134 A RU96115134 A RU 96115134A RU 96115134/04 A RU96115134/04 A RU 96115134/04A RU 96115134 A RU96115134 A RU 96115134A RU 96115134 A RU96115134 A RU 96115134A
Authority
RU
Russia
Prior art keywords
unsubstituted
compound according
carbon atoms
alkyl
methyl
Prior art date
Application number
RU96115134/04A
Other languages
Russian (ru)
Other versions
RU2143429C1 (en
Inventor
Ли Каппс Томас
Джулиан Морер Питер
Original Assignee
Дзе Проктер Энд Гэмбл Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Проктер Энд Гэмбл Компани filed Critical Дзе Проктер Энд Гэмбл Компани
Priority claimed from PCT/US1994/014293 external-priority patent/WO1995016683A1/en
Publication of RU96115134A publication Critical patent/RU96115134A/en
Application granted granted Critical
Publication of RU2143429C1 publication Critical patent/RU2143429C1/en

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Claims (10)

1. Соединение, имеющее следующую формулу
Figure 00000001

где
(a) R представляет собой незамещенный C1-C3 алкил или алкенил, имеющий от 2 до 3 атомов углерода;
(b) R' выбирают из незамещенного C1-C3 алкила или алкенила, имеющего от 2 до 3 атомов углерода, незамещенной алкилтио- или алкоксигруппы, имеющей от 1 до 3 атомов углерода, гидроксигруппы, тиоловой группы, и галогена;
(c) R'' выбирают из водорода, незамещенного C1-C3 алкила или алкенила, имеющего от 2 до 3 атомов углерода, метила, монозамещенного гидрокси-, тиоловой или аминогруппой, незамещенной алкилтио- или алкоксигруппы, имеющей от 1 до 3 атомов углерода, аминогруппы, галогена, незамещенного амида, амидогруппы, незамещенной или замещенной C1-C3 алкилом или алкенилом, имеющим от 2 до 3 атомов углерода, незамещенного сульфоксида, незамещенного сульфонила и цианогруппы.1. The compound having the following formula
Figure 00000001

Where
(a) R is unsubstituted C 1 -C 3 alkyl or alkenyl having from 2 to 3 carbon atoms;
(b) R 'is selected from unsubstituted C 1 -C 3 alkyl or alkenyl having from 2 to 3 carbon atoms, an unsubstituted alkylthio or alkoxy group having from 1 to 3 carbon atoms, hydroxy group, thiol group, and halogen;
(c) R "is selected from hydrogen, unsubstituted C 1 -C 3 alkyl or alkenyl having from 2 to 3 carbon atoms, methyl, monosubstituted by hydroxy, thiol or amino group, unsubstituted alkylthio or alkoxy group having from 1 to 3 atoms carbon, amino, halogen, unsubstituted amide, amido, unsubstituted or substituted with C 1 -C 3 alkyl or alkenyl having from 2 to 3 carbon atoms, unsubstituted sulfoxide, unsubstituted sulfonyl and cyano. 2. Соединение по п. 1, где R'' выбирают из водорода, незамещенного C1-C3 алкила или алкенила, имеющего от 2 до 3 атомов углерода, незамещенной адкилтио- или алкоксигруппы, имеющей от 1 до 3 атомов углерода, цианогруппы, аминогруппы и галогена, R'' предпочтительно незамещен.2. The compound according to claim 1, where R "is selected from hydrogen, unsubstituted C 1 -C 3 alkyl or alkenyl having from 2 to 3 carbon atoms, unsubstituted adkylthio or alkoxy group having from 1 to 3 carbon atoms, cyano, amino and halogen, R "is preferably unsubstituted. 3. Соединение по п. 1 или 2, где R представляет собой метил и алкильная часть P' является метилом. 3. The compound according to claim 1 or 2, wherein R is methyl and the alkyl portion of P ′ is methyl. 4. Соединение по любому из пп. 1 - 3, где R представляет собой алкил, предпочтительно метил, и R' выбирают из метила, этила, метоксигруппы, хлора и брома, предпочтительно метила. 4. The compound according to any one of paragraphs. 1-3, where R is alkyl, preferably methyl, and R 'is selected from methyl, ethyl, methoxy, chlorine and bromine, preferably methyl. 5. Соединение по любому из пп. 1 - 4, где R'' выбирают из водорода, метила, этила, метоксигруппы, цианогруппы, хлора и фтора, предпочтительно из водорода, цианогруппы и фтора, более предпочтительно водорода. 5. The compound according to any one of paragraphs. 1 to 4, where R ″ is chosen from hydrogen, methyl, ethyl, methoxy, cyano, chlorine and fluorine, preferably from hydrogen, cyano and fluorine, more preferably hydrogen. 6. Фармацевтическая композиция, содержащая (a) безопасное и эффективное количество соединения по любому из пп. 1 - 5 и (b) фармацевтически приемлемый носитель. 6. A pharmaceutical composition comprising (a) a safe and effective amount of a compound according to any one of claims. 1 to 5 and (b) a pharmaceutically acceptable carrier. 7. Соединение по любому из пп. 1 - 5, полезное для получения лекарственного средства для предупреждения или лечения назальной закупорки. 7. The compound according to any one of paragraphs. 1 to 5, useful for the preparation of a medicament for the prevention or treatment of nasal obstruction. 8. Соединение по любому из пп. 1 - 5, полезное для получения лекарственного средства для предупреждения или лечения глаукомы. 8. The compound according to any one of paragraphs. 1 to 5, useful for obtaining a drug for the prevention or treatment of glaucoma. 9. Соединение по любому из пп. 1 - 5, полезное для получения лекарственного средства для предупреждения или лечения диареи. 9. The compound according to any one of paragraphs. 1 to 5, useful for obtaining a drug for the prevention or treatment of diarrhea. 10. Соединение по любому из пп. 1 - 5, полезное для получения лекарственного средства для предупреждения или лечения астмы. 10. The compound according to any one of paragraphs. 1 to 5, useful for obtaining a drug for the prevention or treatment of asthma.
RU96115134A 1993-12-17 1994-12-15 DERIVATIVES OF 6-(2-IMIDAZOLINYLAMINO)-QUINOLINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO α-2-ADRENORECEPTORS RU2143429C1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16934393A 1993-12-17 1993-12-17
US08/169,343 1993-12-17
US08/326,564 1994-10-20
PCT/US1994/014293 WO1995016683A1 (en) 1993-12-17 1994-12-15 6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists

Publications (2)

Publication Number Publication Date
RU96115134A true RU96115134A (en) 1998-10-27
RU2143429C1 RU2143429C1 (en) 1999-12-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU96115134A RU2143429C1 (en) 1993-12-17 1994-12-15 DERIVATIVES OF 6-(2-IMIDAZOLINYLAMINO)-QUINOLINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO α-2-ADRENORECEPTORS

Country Status (3)

Country Link
US (1) US5578607A (en)
PE (1) PE37895A1 (en)
RU (1) RU2143429C1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2196792A1 (en) 1994-08-04 1996-02-15 Yoon T. Jeon Novel benzimidazole derivatives
US5804587A (en) * 1995-06-29 1998-09-08 The Procter & Gamble Company 6-(2-imidazolinylamino) quinolines useful as alpha-2 adrenoceptor agonists
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795970A (en) * 1972-02-29 1973-08-27 Pfizer NEW DERIVATIVES OF QUINOLEINE, QUINOXALINE AND QUINAZOLINE ER PHARMACEUTICAL COMPOSITION CONTAINING THEM
US4029792A (en) * 1972-02-29 1977-06-14 Pfizer Inc. (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
US4036976A (en) * 1973-04-05 1977-07-19 Sandoz, Inc. Substituted imidazolinylamino-indazoles
US4217356A (en) * 1975-08-22 1980-08-12 Sandoz Ltd. 2-Imidazolinylamino-2,1,3-benzothiadiazoles
US4398028A (en) * 1977-01-14 1983-08-09 Sandoz Ltd. Bicyclic heterocyclic amino derivatives
EP0025269B1 (en) * 1979-08-23 1985-11-13 Beecham Group Plc Anti-diarrhoea veterinary composition
US4436913A (en) * 1980-09-05 1984-03-13 Siegfried Aktiengesellschaft 1H- and 2H- indazole derivatives
FR2638356A1 (en) * 1988-10-28 1990-05-04 Anben New 2-(arylimino)imidazolidine derivatives for decreasing intraocular pressure and treating glaucoma
US5180721A (en) * 1989-05-22 1993-01-19 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5281591A (en) * 1989-05-22 1994-01-25 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5231096A (en) * 1989-10-12 1993-07-27 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5021416A (en) * 1989-10-31 1991-06-04 Allergan, Inc. Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents

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