RU95118294A - METHOD FOR ISOLATING CEFACLOR FROM A REACTIVE MIXTURE OF ENZYMATIC ACYLATION - Google Patents

METHOD FOR ISOLATING CEFACLOR FROM A REACTIVE MIXTURE OF ENZYMATIC ACYLATION

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Publication number
RU95118294A
RU95118294A RU95118294/04A RU95118294A RU95118294A RU 95118294 A RU95118294 A RU 95118294A RU 95118294/04 A RU95118294/04 A RU 95118294/04A RU 95118294 A RU95118294 A RU 95118294A RU 95118294 A RU95118294 A RU 95118294A
Authority
RU
Russia
Prior art keywords
cefaclor
isolating
salt
reaction mixture
disulfonic acid
Prior art date
Application number
RU95118294/04A
Other languages
Russian (ru)
Other versions
RU2126411C1 (en
Inventor
Пол Гарднер Джон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/014,015 external-priority patent/US5434259A/en
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of RU95118294A publication Critical patent/RU95118294A/en
Application granted granted Critical
Publication of RU2126411C1 publication Critical patent/RU2126411C1/en

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Claims (1)

1. Способ выделения цефаклора из реакционной смеси ферментативного ацилирования, предусматривающий добавление антрахинон-1,5-дисульфокислоты или ее соли с щелочным металлом к названной смеси для образования соли цефаклор/антрахинон-1,5-дисульфокислота в соотношении 2 : 1.1. The method of separation of cefaclor from the reaction mixture of enzymatic acylation, involving the addition of anthraquinone-1,5-disulfonic acid or its salt with an alkali metal to the mixture for the formation of cefaclor / anthrahinon-1,5-disulfonic acid in a ratio of 2: 1. 2. Способ по п.1, отличающийся тем, что реакционная смесь включает соединение формулы
Figure 00000001

3. Способ по п. 2, отличающийся тем, что указанная реакционная смесь включает фенилглицин или его соль.2. The method according to claim 1, wherein the reaction mixture comprises a compound of the formula
Figure 00000001

3. The method according to p. 2, characterized in that the reaction mixture includes phenylglycine or its salt. 4. Способ по п. 3, отличающийся тем, что указанная реакционная смесь включает D-фенилглицинметиловый эфир или его соль. 4. The method according to p. 3, characterized in that the reaction mixture includes D-phenylglycinmethyl ether or its salt. 5. Способ по п.1, отличающийся тем, что антрахинон-1,5-дисульфокислоту добавляют в количестве между примерно 0,5 моль и примерно 2 моль на моль цефаклора. 5. The method according to claim 1, wherein the anthraquinone-1,5-disulfonic acid is added in an amount of between about 0.5 mol and about 2 mol per mol of cefaclor. 6. Способ по п.1, отличающийся тем, что указанное добавление проводят при рH от примерно 1,0 до 4,0, а температура при этом составляет от примерно 0 до примерно 25oС.6. The method according to claim 1, characterized in that the addition is carried out at a pH of from about 1.0 to 4.0, and the temperature is from about 0 to about 25 o C. 7. Способ по п.1, отличающийся тем, что дополнительно включает стадию выделения названной соли цефаклор/антрахинондисульфокислота. 7. The method according to claim 1, characterized in that it further includes a step of isolating said cefaclor / anthraquinone disulfonic acid salt. 8. Способ по п.5, отличающийся тем, что кислоту добавляют в количестве между примерно 0,5 и примерно 0,7 моль на моль цефаклора. 8. The method according to claim 5, wherein the acid is added in an amount of between about 0.5 and about 0.7 mol per mol of cefaclor. 9. Способ по п.6, отличающийся тем, что рН составляет от примерно 1,3 до примерно 1,7, а температура от 0 до 10oС.9. The method according to claim 6, characterized in that the pH is from about 1.3 to about 1.7, and the temperature is from 0 to 10 o C.
RU95118294A 1993-02-05 1994-02-07 Method of isolation of cefaclor from a reaction mixture of an enzymatic acylation RU2126411C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/014,015 US5434259A (en) 1993-02-05 1993-02-05 Process for isolation of cefaclor after enzymatic acylation
US08/014,015 1993-02-05
PCT/US1994/001375 WO1994018209A1 (en) 1993-02-05 1994-02-07 Improved process for isolation of cefaclor after enzymatic acylation

Publications (2)

Publication Number Publication Date
RU95118294A true RU95118294A (en) 1997-09-27
RU2126411C1 RU2126411C1 (en) 1999-02-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU95118294A RU2126411C1 (en) 1993-02-05 1994-02-07 Method of isolation of cefaclor from a reaction mixture of an enzymatic acylation

Country Status (17)

Country Link
US (1) US5434259A (en)
EP (1) EP0682669A4 (en)
JP (1) JPH08506814A (en)
KR (1) KR960701062A (en)
CN (1) CN1042535C (en)
AU (1) AU679209B2 (en)
BR (1) BR9405684A (en)
CA (1) CA2155530A1 (en)
CZ (1) CZ285380B6 (en)
FI (1) FI953728A (en)
HU (1) HU219601B (en)
NO (1) NO953060L (en)
NZ (1) NZ262290A (en)
PL (1) PL174952B1 (en)
RU (1) RU2126411C1 (en)
UA (1) UA41910C2 (en)
WO (1) WO1994018209A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006117616A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Polymorphic form i of lumefantrine and processes for its preparation
CN111057072A (en) * 2019-12-16 2020-04-24 广州维奥康药业科技有限公司 Cefaclor impurity removal method
CN112574233A (en) * 2020-12-30 2021-03-30 苏州盛达药业有限公司 Cefaclor bulk drug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3676434A (en) * 1970-07-29 1972-07-11 Lilly Co Eli Cephalosporin salts
JPS5548797B1 (en) * 1971-04-02 1980-12-08
EP0341991A3 (en) * 1988-05-13 1991-08-28 Eli Lilly And Company Method for recovery of antibiotics from mother liquors and novel pharmaceutically-acceptable salts thereof

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