RU95114740A - Peptides - Google Patents

Peptides

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Publication number
RU95114740A
RU95114740A RU95114740/04A RU95114740A RU95114740A RU 95114740 A RU95114740 A RU 95114740A RU 95114740/04 A RU95114740/04 A RU 95114740/04A RU 95114740 A RU95114740 A RU 95114740A RU 95114740 A RU95114740 A RU 95114740A
Authority
RU
Russia
Prior art keywords
compound
formula
complex
radionuclide
pharmaceutically acceptable
Prior art date
Application number
RU95114740/04A
Other languages
Russian (ru)
Other versions
RU2156774C2 (en
Inventor
Райнер Альберт
Питер СМИТ-ДЖОНС
Гизберт ВЕКБЕКЕР
Кристиан БРУНЗ
Барбара ШТОЛЬЦ
Original Assignee
Сандоз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9417873A external-priority patent/GB9417873D0/en
Application filed by Сандоз Лтд. filed Critical Сандоз Лтд.
Publication of RU95114740A publication Critical patent/RU95114740A/en
Application granted granted Critical
Publication of RU2156774C2 publication Critical patent/RU2156774C2/en

Links

Claims (13)

1. Соединение формулы I
Figure 00000001

где М является катионом;
А является Рhе или Туr,
в свободной форме, в форме соли или комплекса с радионуклидом.1. The compound of formula I
Figure 00000001

where M is a cation;
A is Phe or Tur,
in free form, in salt form or complex with a radionuclide. 2. Соединение по п. 1, отличающееся тем, что А является Туr. 2. The compound according to claim 1, characterized in that A is Tu. 3. Соединение по пп. 1 и 2, отличающееся тем, что указанное соединение является комплексом с 90Y.3. Connection on PP. 1 and 2, characterized in that the compound is a complex with 90 Y. 4. Соединение по пп. 1 и 2, отличающееся тем, что указанное соединение является комплексом с 161Tb.4. Connection on PP. 1 and 2, characterized in that the compound is a complex with 161 Tb. 5. Соединение по пп. 1-4, отличающееся тем, что М является Н+.5. Connection on PP. 1-4, characterized in that M is H + . 6. Радиофармацевтическое средство, отличающееся тем, что оно представляет собой соединение формулы I по п. 1 в виде комплекса с радионуклидом или его фармацевтически приемлемой соли. 6. Radiopharmaceutical agent, characterized in that it is a compound of formula I according to claim 1 in the form of a complex with a radionuclide or its pharmaceutically acceptable salt. 7. Способ лечения опухолей и метастазов, положительных по соматостатиновым рецепторам, отличающийся тем, что для лечения используют соединение формулы I по п. 1. 7. A method of treating tumors and metastases positive for somatostatin receptors, characterized in that the treatment uses the compound of formula I according to claim 1. 8. Способ изготовления радиофармацевтического состава, отличающийся тем, что для изготовления указанного состава используют соединение формулы I по п. 1 или его фармацевтически приемлемые соли. 8. A method of manufacturing a radiopharmaceutical composition, characterized in that for the manufacture of the specified composition using the compound of formula I under item 1 or its pharmaceutically acceptable salts. 9. Фармацевтический состав, отличающийся тем, что он содержит соединение формулы I по пп. 1-5 или его фармацевтически приемлемую соль вместе с одним или несколькими фармацевтически приемлемыми носителями или растворителями. 9. Pharmaceutical composition, characterized in that it contains a compound of formula I on PP. 1-5 or its pharmaceutically acceptable salt together with one or more pharmaceutically acceptable carriers or solvents. 10. Состав по п. 9, отличающийся тем, что он дополнительно содержит стабилизатор. 10. The composition according to p. 9, characterized in that it additionally contains a stabilizer. 11. Состав по п. 10, отличающийся тем, что стабилизатор выбран из группы, состоящей из сывороточного альбумина, аскорбиновой кислоты, ретинола, гентизиновой кислоты или их производных и аминокислотного раствора. 11. The composition according to p. 10, characterized in that the stabilizer is selected from the group consisting of serum albumin, ascorbic acid, retinol, gentisic acid or their derivatives and amino acid solution. 12. Способ образования комплекса с радионуклидом соединения формулы I по п. 1, при котором соединение формулы I подвергают взаимодействию с образующим радионуклид соединением при температуре от 60 до 120oС возможно в присутствии стабилизатора.12. A method of forming a complex with a radionuclide of a compound of formula I according to claim 1, wherein the compound of formula I is reacted with the compound forming the radionuclide at a temperature of from 60 to 120 o C possible in the presence of a stabilizer. 13. Терапевтический набор для применения при лечении опухолевой инвазивности или симптомов, ассоциированных с опухолевым ростом, отличающийся тем, что он включает фармацевтический состав, содержащий соединение формулы I в виде комплекса с радионуклидом, или его фармацевтически приемлемую соль и, кроме того, включает по меньшей мере один фармацевтический состав, содержащий цитостатический агент. 13. Therapeutic kit for use in the treatment of tumor invasiveness or symptoms associated with tumor growth, characterized in that it includes a pharmaceutical composition containing the compound of formula I in the form of a complex with a radionuclide, or its pharmaceutically acceptable salt and, in addition, includes at least at least one pharmaceutical formulation containing a cytostatic agent.
RU95114740/04A 1994-09-06 1995-09-04 Somastatinic peptides, radiopharmaceutical agent, method of treating tumors, and pharmaceutical composition RU2156774C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9417873A GB9417873D0 (en) 1994-09-06 1994-09-06 Organic compounds
GB9417873.8 1994-09-06

Publications (2)

Publication Number Publication Date
RU95114740A true RU95114740A (en) 1997-08-27
RU2156774C2 RU2156774C2 (en) 2000-09-27

Family

ID=10760870

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95114740/04A RU2156774C2 (en) 1994-09-06 1995-09-04 Somastatinic peptides, radiopharmaceutical agent, method of treating tumors, and pharmaceutical composition

Country Status (31)

Country Link
US (2) US6183721B1 (en)
EP (1) EP0714911B1 (en)
JP (1) JP3054346B2 (en)
KR (1) KR100364111B1 (en)
CN (1) CN1185252C (en)
AT (1) ATE199561T1 (en)
AU (1) AU703057B2 (en)
BR (1) BR9503936A (en)
CA (1) CA2157530C (en)
CO (1) CO4410344A1 (en)
CZ (1) CZ287012B6 (en)
DE (1) DE69520256T2 (en)
DK (1) DK0714911T3 (en)
ES (1) ES2157309T3 (en)
FI (1) FI117424B (en)
GB (1) GB9417873D0 (en)
GR (1) GR3035997T3 (en)
HU (1) HU218284B (en)
IL (1) IL115154A (en)
NO (1) NO316569B1 (en)
NZ (1) NZ272919A (en)
PE (1) PE41496A1 (en)
PL (1) PL182434B1 (en)
PT (1) PT714911E (en)
RU (1) RU2156774C2 (en)
SG (1) SG50356A1 (en)
SI (1) SI0714911T1 (en)
SK (1) SK283774B6 (en)
TR (1) TR199501094A2 (en)
TW (1) TW387898B (en)
ZA (1) ZA957475B (en)

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JP2004529884A (en) 2001-02-26 2004-09-30 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー Ascorbic acid analogs for metal radiopharmaceuticals
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US20050118099A1 (en) * 2003-03-10 2005-06-02 Braslawsky Gary R. Thiol-mediated drug attachment to targeting peptides
WO2006009901A2 (en) 2004-06-18 2006-01-26 Ambrx, Inc. Novel antigen-binding polypeptides and their uses
US20100029911A1 (en) * 2004-11-24 2010-02-04 Aplagen Gmbh Method For Solid-Phase Peptide Synthesis And Purification
CA2699394C (en) 2007-09-17 2020-03-24 The Regents Of The University Of California Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
EP2684048B1 (en) 2011-03-11 2018-10-03 Board of Regents of the University of Nebraska Biomarker for coronary artery disease
EP2922578B1 (en) 2012-11-21 2018-12-12 Serene, Llc Tin-117m comprising somatostatin receptor binding compounds
CN103275189B (en) * 2013-06-06 2014-08-06 深圳翰宇药业股份有限公司 Cracking liquid for peptide resin, and application thereof in synthesizing somatostatin by solid phase cracking
US10946106B2 (en) 2015-11-30 2021-03-16 The Regents Of The University Of California Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen
US11235076B2 (en) 2016-08-29 2022-02-01 Fred Hutchinson Cancer Research Center Chelating platform for delivery of radionuclides
PT3568205T (en) 2017-01-12 2023-10-26 Radiomedix Inc Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes
TW202017600A (en) * 2018-06-21 2020-05-16 法商艾普森藥品公司 Composition containing a somatostatin analogue for radiopharmaceutical use
TW202015744A (en) 2018-06-21 2020-05-01 法商艾普森藥品公司 Composition containing a somatostatin analogue for radiopharmaceutical use
US10596276B2 (en) 2018-07-25 2020-03-24 Advanced Accelerator Applications (Italy) S.R.L. Stable, concentrated radionuclide complex solutions
US10596278B2 (en) 2018-07-25 2020-03-24 Advanced Accelerator Applications (Italy) S.R.L. Stable, concentrated radionuclide complex solutions
JP2023534765A (en) 2020-08-07 2023-08-10 フォーティス セラピューティクス，インク． CD46 targeting immune complexes and methods of use thereof

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AU630362B2 (en) * 1988-05-25 1992-10-29 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Macrocyclic chelates & methods of use thereof
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