RU94031165A - Применение арил-индол-производных для лечения психозов и способ лечения - Google Patents
Применение арил-индол-производных для лечения психозов и способ леченияInfo
- Publication number
- RU94031165A RU94031165A RU94031165/14A RU94031165A RU94031165A RU 94031165 A RU94031165 A RU 94031165A RU 94031165/14 A RU94031165/14 A RU 94031165/14A RU 94031165 A RU94031165 A RU 94031165A RU 94031165 A RU94031165 A RU 94031165A
- Authority
- RU
- Russia
- Prior art keywords
- hydrogen
- alkyl
- cycloalkylmethyl
- cycloalkyl
- alkenyl
- Prior art date
Links
- 208000028017 Psychotic disease Diseases 0.000 title claims abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 12
- 239000001257 hydrogen Substances 0.000 claims abstract 12
- 125000000217 alkyl group Chemical group 0.000 claims abstract 9
- 150000002431 hydrogen Chemical class 0.000 claims abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 4
- 229910052799 carbon Chemical group 0.000 claims abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 4
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims abstract 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 4
- 239000001301 oxygen Substances 0.000 claims abstract 4
- 229910052717 sulfur Chemical group 0.000 claims abstract 4
- 239000011593 sulfur Chemical group 0.000 claims abstract 4
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 claims abstract 2
- 210000004556 brain Anatomy 0.000 claims abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims abstract 2
- 229960003638 dopamine Drugs 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims abstract 2
- 239000011737 fluorine Substances 0.000 claims abstract 2
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- 210000002569 neuron Anatomy 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 claims abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 2
- -1 cyan Chemical group 0.000 claims 1
- 230000005284 excitation Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000002269 spontaneous effect Effects 0.000 claims 1
- 230000002861 ventricular Effects 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000008925 spontaneous activity Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK2065/91 | 1991-12-23 | ||
| DK912065A DK206591D0 (da) | 1991-12-23 | 1991-12-23 | Behandling af psykoser |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU94031165A true RU94031165A (ru) | 1996-06-20 |
Family
ID=8109829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94031165/14A RU94031165A (ru) | 1991-12-23 | 1992-12-21 | Применение арил-индол-производных для лечения психозов и способ лечения |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0618799A1 (enExample) |
| JP (1) | JPH07502517A (enExample) |
| AU (1) | AU668537B2 (enExample) |
| CA (1) | CA2126571A1 (enExample) |
| CZ (1) | CZ153994A3 (enExample) |
| DK (1) | DK206591D0 (enExample) |
| NO (1) | NO942378L (enExample) |
| RU (1) | RU94031165A (enExample) |
| SK (1) | SK75794A3 (enExample) |
| WO (1) | WO1993012790A1 (enExample) |
| ZA (1) | ZA9210001B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5554030A (en) * | 1994-06-30 | 1996-09-10 | Minnesota Mining And Manufacturing Company | Method for bonding non-amalgam restorative materials to dental surfaces |
| EA000769B1 (ru) * | 1996-03-25 | 2000-04-24 | Эли Лилли Энд Компани | Способ лечения при боли, вызванной мигренью |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| GB8908085D0 (en) * | 1989-04-11 | 1989-05-24 | Lundbeck & Co As H | New therapeutic use |
| DK158590D0 (da) * | 1990-07-02 | 1990-07-02 | Lundbeck & Co As H | Indolderivater |
| DK238190D0 (da) * | 1990-10-03 | 1990-10-03 | Lundbeck & Co As H | Depotderivater |
| DK8492D0 (da) * | 1992-01-23 | 1992-01-23 | Lundbeck & Co As H | Behandling af psykoser |
-
1991
- 1991-12-23 DK DK912065A patent/DK206591D0/da not_active Application Discontinuation
-
1992
- 1992-12-21 CZ CZ941539A patent/CZ153994A3/cs unknown
- 1992-12-21 JP JP5511365A patent/JPH07502517A/ja active Pending
- 1992-12-21 SK SK757-94A patent/SK75794A3/sk unknown
- 1992-12-21 WO PCT/DK1992/000390 patent/WO1993012790A1/en not_active Ceased
- 1992-12-21 RU RU94031165/14A patent/RU94031165A/ru unknown
- 1992-12-21 AU AU33452/93A patent/AU668537B2/en not_active Ceased
- 1992-12-21 EP EP93902096A patent/EP0618799A1/en not_active Ceased
- 1992-12-21 CA CA002126571A patent/CA2126571A1/en not_active Abandoned
- 1992-12-23 ZA ZA9210001A patent/ZA9210001B/xx unknown
-
1994
- 1994-06-22 NO NO942378A patent/NO942378L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU668537B2 (en) | 1996-05-09 |
| NO942378D0 (enExample) | 1994-06-22 |
| JPH07502517A (ja) | 1995-03-16 |
| WO1993012790A1 (en) | 1993-07-08 |
| DK206591D0 (da) | 1991-12-23 |
| SK75794A3 (en) | 1995-04-12 |
| AU3345293A (en) | 1993-07-28 |
| ZA9210001B (en) | 1994-01-13 |
| NO942378L (no) | 1994-06-22 |
| CZ153994A3 (en) | 1995-06-14 |
| CA2126571A1 (en) | 1993-07-08 |
| EP0618799A1 (en) | 1994-10-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1259487B8 (en) | 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors | |
| BR9916282A (pt) | Composto, uso de um um composto e método de tratamento | |
| KR910006225A (ko) | 벤조일구아니딘, 이의 제조방법. 약제로서의 이의 용도 및 이를 함유하는 약제 | |
| RU94045155A (ru) | Способы ингибирования болезни альцгеймера | |
| ES2143526T3 (es) | Derivados de amida que tienen actividad antihipercolesterolemica, su preparacion y sus usos terapeuticos. | |
| RU94044453A (ru) | Применение 2-фенил-3-ароилбензотиофенов для ингибирования себореи и угрей | |
| RU94044454A (ru) | Ингибитор аутоимунных заболеваний | |
| RU94044356A (ru) | Применение 2-фенил-3-ароилбензотиофенов для увеличения экспрессии тромбомодулина для ингибирования тромботического расстройства, для увеличения активации протеина с | |
| ES2101858T3 (es) | Derivados de geneserina como inhibidores de colinesterasa. | |
| ATE398449T1 (de) | Verwendung von azetidincarboxamidderivaten in therapie | |
| DE69907419D1 (en) | Antitumorwirkstoffe | |
| RU94037246A (ru) | Применение 2-фенил-3-ароилбензотиофенов для ингибирования разрушения хряща | |
| RU94044489A (ru) | Применение 2-фенил-3-ароилбензотиофенов для ингибирования миелопероксидазной активности | |
| RU98119076A (ru) | Производные 2-(3h)-оксазолона и их применение в качестве ингибиторов сох-2 | |
| RU94045277A (ru) | Применение 2-фенил-3-ароилбензотиофенов для ингибирования расстройств цнс у женщин в постменопаузе | |
| NO833900L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive naftalenderivater | |
| RU94045271A (ru) | Применение 2-фенил-3-ароилбензотиофенов для ингибирования синдрома тернера | |
| EP0645382A4 (en) | CUMARIN DERIVATIVES AND THEIR USE. | |
| RU94045156A (ru) | Применение 2-фенил-3-ароилбензотиофенов для ингибирования преждевременного полового созревания | |
| RU94031165A (ru) | Применение арил-индол-производных для лечения психозов и способ лечения | |
| ES2082894T3 (es) | Dihidropirido(4,3-d)pirimidinas 4-sustituidas como analgesicos y agentes antiinflamatorios topicos para el tratamiento de enfermedades de la piel. | |
| RU2002105518A (ru) | Гетероциклические соединения, ингибирующие ангиогенез | |
| ATE18761T1 (de) | Carbamoyloxybenzhydrol-derivate, ihre herstellung und ihre pharmazeutische zusammensetzungen. | |
| RU94035658A (ru) | Применение 3-арилиндольных и 3-арилиндазольных производных для лечения психозов, способ лечения | |
| RU94044457A (ru) | Применение бензтиофенов для ингибирования гирсутизма и алопеции у женщин |