RU94023134A - METHOD FOR ISOLATION AND CLEANING OF INSULIN AND ITS BIOTECHNOLOGICAL PRECURSORS - Google Patents
METHOD FOR ISOLATION AND CLEANING OF INSULIN AND ITS BIOTECHNOLOGICAL PRECURSORSInfo
- Publication number
- RU94023134A RU94023134A RU94023134/13A RU94023134A RU94023134A RU 94023134 A RU94023134 A RU 94023134A RU 94023134/13 A RU94023134/13 A RU 94023134/13A RU 94023134 A RU94023134 A RU 94023134A RU 94023134 A RU94023134 A RU 94023134A
- Authority
- RU
- Russia
- Prior art keywords
- biotechnological
- copolymer
- insulin
- cross
- methacrylate monomer
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims 8
- 102000004877 Insulin Human genes 0.000 title claims 4
- 108090001061 Insulin Proteins 0.000 title claims 4
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 title claims 4
- 102000014961 Protein Precursors Human genes 0.000 title claims 3
- 108010078762 Protein Precursors Proteins 0.000 title claims 3
- 238000004140 cleaning Methods 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 4
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 4
- 239000000178 monomer Substances 0.000 claims 4
- 150000001768 cations Chemical class 0.000 claims 2
- 238000011033 desalting Methods 0.000 claims 2
- 239000002594 sorbent Substances 0.000 claims 2
- 102000037197 Anion exchangers Human genes 0.000 claims 1
- 108091006437 Anion exchangers Proteins 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 230000002209 hydrophobic Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002743 phosphorus functional group Chemical group 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU94023134A RU2081122C1 (en) | 1994-06-16 | 1994-06-16 | Method of isolation and purification of insulin or its biotechnological precursors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU94023134A RU2081122C1 (en) | 1994-06-16 | 1994-06-16 | Method of isolation and purification of insulin or its biotechnological precursors |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94023134A true RU94023134A (en) | 1996-02-20 |
RU2081122C1 RU2081122C1 (en) | 1997-06-10 |
Family
ID=20157370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94023134A RU2081122C1 (en) | 1994-06-16 | 1994-06-16 | Method of isolation and purification of insulin or its biotechnological precursors |
Country Status (1)
Country | Link |
---|---|
RU (1) | RU2081122C1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2251426C1 (en) * | 2003-09-18 | 2005-05-10 | Цыганков Владимир Владимирович | Method for obtaining insulin out of natural source and insulin |
-
1994
- 1994-06-16 RU RU94023134A patent/RU2081122C1/en not_active IP Right Cessation
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