RU94021660A - NEW CONNECTIONS AS POTENTIAL INDUCTORS OF TERMINAL DIFFERENTIATION OF TUMOR CELLS, PHARMACEUTICAL COMPOSITION ON THEIR BASIS AND TREATMENT METHOD - Google Patents

NEW CONNECTIONS AS POTENTIAL INDUCTORS OF TERMINAL DIFFERENTIATION OF TUMOR CELLS, PHARMACEUTICAL COMPOSITION ON THEIR BASIS AND TREATMENT METHOD

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Publication number
RU94021660A
RU94021660A RU94021660/04A RU94021660A RU94021660A RU 94021660 A RU94021660 A RU 94021660A RU 94021660/04 A RU94021660/04 A RU 94021660/04A RU 94021660 A RU94021660 A RU 94021660A RU 94021660 A RU94021660 A RU 94021660A
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Russia
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substituents
group
provides
pharmaceutical composition
tumor cells
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RU94021660/04A
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Russian (ru)
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RU2128643C1 (en
Inventor
Бреслоу Рональд
А.Маркс Пол
А.Рифкинд Ричард
Джурсик Бранко
Original Assignee
Слоан-Кеттеринг Инститьют фор Кэнсер Рисерч дзе Трастиз оф Колумбия Юниверсити ин дзе Сити оф Нью-Йорк
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Priority claimed from US07/771,760 external-priority patent/US5369108A/en
Application filed by Слоан-Кеттеринг Инститьют фор Кэнсер Рисерч дзе Трастиз оф Колумбия Юниверсити ин дзе Сити оф Нью-Йорк filed Critical Слоан-Кеттеринг Инститьют фор Кэнсер Рисерч дзе Трастиз оф Колумбия Юниверсити ин дзе Сити оф Нью-Йорк
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Claims (1)

Изобретение предлагает соединение, имеющее структуру (I):
Figure 00000001

и отличающееся тем, что каждый из заместителей R1 и R2, независимо друг от друга, принимает одинаковые или разные значения; если заместители R1 и R2 являются одинаковыми, каждый из них представляет собой замещенный или незамещенный ариламино, циклоалкиламино, пиридиламино, пиперидино, 9 - пурин - 6 - амино или тиазолиламиногруппу; если заместители R1 и R2 различны, то R1 представляет собой группу R3 - N - R1, где каждый из заместителей R3 и R4 независимо друг от друга принимает одинаковые или разные значения и представляет собой атом водорода, гидроксильную группу, замещенный или незамещенный, линейный или разветвленный алкил, алкенил, циклоалкил, арил, алкилокси-, арилокси-, арилалкилокси- или пиридильную группу, или заместители R3 и R4 вместе образуют пиперидиновую группу, а заместитель R2 представляет собой гидроксиламино-, гидроксильную, амино-, алкиламино-, диалкиламино- или алкоксильную группу; и n принимает целые значения от приблизительно 4 до приблизительно 8. Данное изобретение также предлагает способ селективного индуцирования терминальной дифференциации клеток опухоли и в результате ингибирования быстрого размножения таких клеток. Более того, изобретение предлагает способ лечения пациента, имеющего опухоль, характеризующуюся быстрым размножением клеток. И, наконец, настоящее изобретение предлагает фармацевтическую композицию, содержащую фармацевтически приемлемый носитель и терапевтически эффективное количество описанного выше соединения.The invention provides a compound having structure (I):
Figure 00000001

and characterized in that each of the substituents R 1 and R 2 , independently of one another, takes the same or different values; if the substituents R 1 and R 2 are the same, each of them is a substituted or unsubstituted arylamino, cycloalkylamino, pyridylamino, piperidino, 9 - purine - 6 - amino or thiazolylamino group; if the substituents R 1 and R 2 are different, then R 1 is a group R 3 - N - R 1 , where each of the substituents R 3 and R 4 independently of each other takes the same or different values and represents a hydrogen atom, a hydroxyl group, substituted or unsubstituted, linear or branched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy or pyridyl group, or the substituents R 3 and R 4 together form a piperidine group, and the substituent R 2 represents a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino - or CNS group; and n takes integer values from about 4 to about 8. This invention also provides a method for selectively inducing terminal differentiation of tumor cells and as a result of inhibiting the rapid multiplication of such cells. Moreover, the invention provides a method for treating a patient having a tumor characterized by the rapid proliferation of cells. Finally, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound as described above.
RU94021660A 1991-10-04 1992-10-05 New compounds as potential inducers of terminal differentiation of tumor cells, a pharmaceutical composition based on said RU2128643C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/771,760 US5369108A (en) 1991-10-04 1991-10-04 Potent inducers of terminal differentiation and methods of use thereof
US771760 1991-10-04
PCT/US1992/008454 WO1993007148A1 (en) 1991-10-04 1992-10-05 Novel potent inducers of terminal differentiation and methods of use thereof

Publications (2)

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RU94021660A true RU94021660A (en) 1995-08-20
RU2128643C1 RU2128643C1 (en) 1999-04-10

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US (3) US5369108A (en)
EP (1) EP0642509B1 (en)
JP (4) JP3432823B2 (en)
KR (2) KR100263264B1 (en)
AT (1) ATE183185T1 (en)
AU (1) AU668696B2 (en)
CA (1) CA2120619C (en)
CL (1) CL2008002943A1 (en)
DE (1) DE69229800T2 (en)
ES (1) ES2134815T3 (en)
FI (1) FI941537A (en)
HU (1) HU225497B1 (en)
RU (1) RU2128643C1 (en)
WO (1) WO1993007148A1 (en)

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