RU94000405A - Method for evaluation of pain-relieving effect of medicinal drugs
- Google Patents
Method for evaluation of pain-relieving effect of medicinal drugs
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Publication number
RU94000405A
RU94000405ARU94000405/14ARU94000405ARU94000405ARU 94000405 ARU94000405 ARU 94000405ARU 94000405/14 ARU94000405/14 ARU 94000405/14ARU 94000405 ARU94000405 ARU 94000405ARU 94000405 ARU94000405 ARU 94000405A
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Application filed by И.В. Горбоносов, Ф.В. СеменовfiledCriticalИ.В. Горбоносов
Priority to RU9494000405ApriorityCriticalpatent/RU2077261C1/en
Publication of RU94000405ApublicationCriticalpatent/RU94000405A/en
Application grantedgrantedCritical
Publication of RU2077261C1publicationCriticalpatent/RU2077261C1/en
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
FIELD: medicine; clinical pharmacology. SUBSTANCE: method involves recording skin potential variation in response to gulps performed by the patient after tonsillectomy prior to and after administration of medicinal drugs. EFFECT: less costly method; more objective evaluation of analgesic activity.
Claims (1)
Предлагаемое изобретение относится к медицине, а именно к клинической фармакологии, и может быть использовано для клинической оценки анальгетической активности лекарственных препаратов. Сущностью изобретения является регистрация изменений кожного потенциала в ответ на глотательное движение больного, перенесшего тонзиллэктомию, до и после введения лекарственных препаратов. Предложенный способ позволяет объективно оценить анальгетическую активность лекарственного препарата. При этом оценивается реакция организма не на искусственный болевой раздражитель, а на болевое ощущение из патологического очага. Способ легко воспроизводим в клинике и не требует дорогостоящей аппаратуры. При исследовании этим способом анальгетической активности бензофурокаина отмечалась четкая корреляция субъективных ощущений больных с величиной изменений кожного потенциала.The present invention relates to medicine, namely to clinical pharmacology, and can be used for clinical evaluation of the analgesic activity of drugs. The essence of the invention is the registration of changes in skin potential in response to the swallowing movement of a patient who has undergone tonsillectomy, before and after administration of drugs. The proposed method allows you to objectively evaluate the analgesic activity of the drug. In this case, the reaction of the body is evaluated not to an artificial pain stimulus, but to a pain sensation from a pathological focus. The method is easily reproducible in the clinic and does not require expensive equipment. In the study of the analgesic activity of benzofurocain by this method, a clear correlation was observed between the subjective sensations of patients and the magnitude of changes in skin potential.
RU9494000405A1994-01-051994-01-05Method to evaluate anesthetic effect of medicinal products
RU2077261C1
(en)
Common factors contributing to intractable pain and medical problems with insufficient drug uptake in areas to be treated, and their pathogenesis and treatment: Part I. Combined use of medication with acupuncture,(+) Qi gong energy-stored material, soft laser or electrical stimulation