RU93058561A - DERIVATIVES OF AROMATOSIS SELECTIVELY 4 (5) -IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION ON THEIR BASIS - Google Patents

DERIVATIVES OF AROMATOSIS SELECTIVELY 4 (5) -IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION ON THEIR BASIS

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Publication number
RU93058561A
RU93058561A RU93058561/04A RU93058561A RU93058561A RU 93058561 A RU93058561 A RU 93058561A RU 93058561/04 A RU93058561/04 A RU 93058561/04A RU 93058561 A RU93058561 A RU 93058561A RU 93058561 A RU93058561 A RU 93058561A
Authority
RU
Russia
Prior art keywords
derivatives
aromatosis
selectively
basis
pharmaceutical composition
Prior art date
Application number
RU93058561/04A
Other languages
Russian (ru)
Inventor
Йоханнес Карьялайнен Арто
Седервалл Марья-Лиса
Маркетта Калапудас Арья
Олави Пелконен Рейно
Марья Лайне Айре
Арво Сакари Ламминтауста Ристо
Сакари Салонен Ярмо
Original Assignee
Орион-Ихтюмя Ой
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орион-Ихтюмя Ой filed Critical Орион-Ихтюмя Ой
Publication of RU93058561A publication Critical patent/RU93058561A/en

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Claims (1)

Предложены новые производные 4/5/-имидазола общей формулы
Figure 00000001

где A -
Figure 00000002

или
Figure 00000003

где один из R1 и R2 представляет собой CN, а другой H, CH3, OCH3, NO2, NH2, CN, CF3, CHF2, CH2f или галоген, R1 - H или
Figure 00000004

где R3 - H, CH3 или галоген, R4 - H и R5 - H или R4 и R5 вместе образуют связь, n - 1 или 2, y - 0, 1, 2, их стереоизомеры и их нетоксичные фармацевтически приемлемые соли присоединения кислоты обнаруживают свойства селективного ингибирования ароматазы, сравнимые с их свойствами ингибирования десмолазы. Предложенные соединения полезны при лечении заболеваний, зависящих от эстрогена, например рака молочной железы или гиперплазии предстательной железы (ВРН).Proposed New Derivatives of 4/5 / -imidazole of General Formula
Figure 00000001

where A is
Figure 00000002

or
Figure 00000003

where one of R 1 and R 2 represents CN, and the other H, CH 3 , OCH 3 , NO 2 , NH 2 , CN, CF 3 , CHF 2 , CH 2 f or halogen, R 1 - H or
Figure 00000004

where R 3 - H, CH 3 or halogen, R 4 - H and R 5 - H or R 4 and R 5 together form a bond, n - 1 or 2, y - 0, 1, 2, their stereoisomers and their non-toxic pharmaceutically acceptable acid addition salts exhibit properties of selective aromatase inhibition comparable to their desmolase inhibition properties. The compounds of the invention are useful in the treatment of estrogen-dependent diseases, for example, breast cancer or prostate hyperplasia (BPH).
RU93058561/04A 1991-06-18 1992-06-12 DERIVATIVES OF AROMATOSIS SELECTIVELY 4 (5) -IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION ON THEIR BASIS RU93058561A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB91131425 1991-06-18
GB91259242 1991-12-05

Publications (1)

Publication Number Publication Date
RU93058561A true RU93058561A (en) 1996-12-27

Family

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